Zobrazeno 1 - 10
of 39
pro vyhledávání: '"William C. Hunter"'
Autor:
Jerome P. Trzeciakowski, William C. Hunter, Nancy L. Sehgel, Zhongkui Hong, Yi Zhu, Stephen F. Vatner, Zhe Sun, Dorothy E. Vatner, Gerald A. Meininger
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H1281-H1287
Increased vascular stiffness is fundamental to hypertension, and its complications, including atherosclerosis, suggest that therapy should also be directed at vascular stiffness, rather than just the regulation of peripheral vascular resistance. It i
Autor:
Hongyu Qiu, Guy M. Genin, Stephen F. Vatner, Zhe Sun, Jerome P. Trzeciakowski, Christophe Depre, Filipinas F. Natividad, Yi Zhu, Elliot L. Elson, Gerald A. Meininger, Meredith Gansner, William C. Hunter, Dorothy E. Vatner, Ranillo R.G. Resuello
Publikováno v:
Circulation Research. 107:615-619
Rationale: Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM). Objective: We tested the hypothesis th
Autor:
William C. Hunter
Publikováno v:
Cardiology Clinics. 18:443-457
Myocardial relaxation is governed by the interplay of two macromolecular systems: (1) myofilaments and (2) calcium extruding pumps/exchangers. In myocardium from failing hearts, both systems act more slowly than normal, and cause relaxation to decele
Publikováno v:
Journal of the American College of Cardiology. 33(6):1735-1742
Asynchronous electrical activation of the ventricles, as during left bundle branch block (LBBB) and during ventricular pacing, is associated with abnormal, locally different contraction patterns (1-3) and deficiencies in perfusion and glucose uptake
Publikováno v:
Europe PubMed Central
Length-dependent steady-state and dynamic responses of five models of isometric force generation in cardiac myofilaments were compared with similar experimental data from the literature. The models were constructed by assuming different subsets of th
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 272:H469-H477
Previous studies of regional differences in myocardial deformation between the anterior and posterior walls of the canine left ventricle were based on strain, which is not an absolute measure of deformation. We thus compared sarcomere lengths at ante
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 264:H1817-H1824
Recent clinical and animal studies have suggested that ventricular-vascular coupling normally operates at either optimal ventricular efficiency (EFF = stroke work/myocardial oxygen consumption) or stroke work (SW) and that efficiency in particular is
Publikováno v:
Circulation. 86:1945-1954
BACKGROUND Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat. The additional amount of oxygen that is consumed by the heart to cycle this additional Ca2+ is believed to reduce myocard
Publikováno v:
Journal of Molecular and Cellular Cardiology. 24:783-797
The agent 2,3-butanedione monoxime (BDM) has been reported to reduce the sensitivity of myofilament force development to calcium ions, without affecting the calcium transient in myocardium. One would predict, therefore, that BDM should reduce the con
Autor:
H. F. Weisman, M. J. Royce, Edward K. Rodriguez, Michelle K. Leppo, A.S. Douglas, William C. Hunter
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 263:H293-H306
The ability to measure cyclic changes in myocardial sarcomere lengths and orientations during cardiac ejection and filling would improve our understanding of how the cellular processes of contraction relate to the pumping of the whole heart. Previous