Zobrazeno 31 - 39
of 39
pro vyhledávání: '"William C. Hunter"'
Publikováno v:
Circulation. 72:654-659
Although the rate dependence of isolated muscle contractility is well known, the ventricular end-systolic pressure-volume relationship (ESPVR) has been reported to be insensitive to heart rate. To resolve this contradiction, we used an isolated, ejec
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 256:H1726-H1734
Mechanical studies of isolated cardiac muscle are complicated as a result of damage inflicted on the ends of the muscle during excision and mounting procedures. Inhomogeneities between the healthy central and weakened end portions of the muscle make
Publikováno v:
Circulation Research. 60:770-779
The dynamic stiffness of excised cardiac muscles that would be likely to have different intrinsic speeds of contraction, as judged by previous biochemical reports of their myosin ATPase rates, was compared. This study included muscles from thyrotoxic
Publikováno v:
Circulation Research. 56:340-350
We established, for the isolated, isovolumically beating canine left ventricle, a comprehensive description of postextrasystolic contractile strength (dP/dtmax) as a function of extrasystolic and postextrasystolic stimulus intervals. In contrast to p
Publikováno v:
The American journal of physiology. 237(3)
Autor:
Karl T. Weber, Sanjeev G. Shroff, Joseph S. Janicki, Alfred P. Fishman, Eugene S. Pearlman, William C. Hunter
Publikováno v:
Progress in cardiovascular diseases. 24(5)
The integrated function of the heart and lungs provides for the transfer of O 2 from the atmosphere, for its delivery to the metabolizing tissues, and for the removal of CO 2 . When cardiac output is compromised as in heart failure, a series of refle
Publikováno v:
Circulation research. 64(2)
We studied the effect of ejection on end-systolic pressure in isolated heart preparations. Ejecting beats were compared with isovolumic beats having the same volume as at end systole. While holding end-systolic volume constant, various stroke volumes
Publikováno v:
The American journal of physiology. 246(1 Pt 2)
We measured cardiac mechanical restitution curves, which describe the time course of recovery of ventricular contractile strength following a steady-state beat. In the first series of experiments, we studied left ventricles that beat isovolumically t
Publikováno v:
The American journal of physiology. 251(6 Pt 2)
A new analytical method (sequential convolution) for describing ventricular-vascular interactions was used to predict instantaneous pressure and flow in four isolated canine left ventricles ejecting into a computer-simulated arterial system. Ventricu
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