Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jerome P. Trzeciakowski"'
Autor:
Jerome P. Trzeciakowski, R. John Solaro, Paola C Rosas, Heidi A. Creed, Chad M. Warren, Carl W. Tong
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 817-830 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 817-830 (2019)
Visual Abstract
Highlights • With aging, phosphorylated-mimetic cMyBP-C mice exhibited better survival, better preservation of systolic and diastolic functions, and unchanging wall thickness compared with control mice. • Aged wild-type equiv
Highlights • With aging, phosphorylated-mimetic cMyBP-C mice exhibited better survival, better preservation of systolic and diastolic functions, and unchanging wall thickness compared with control mice. • Aged wild-type equiv
Autor:
Yang Liu, Sakthivel Sadayappan, Suresh Govindan, Carl W. Tong, Elizabeth Ebert, Jerome P. Trzeciakowski, M. Karen Newell-Rogers, David T. Kidwell, Paola C Rosas, Dustin W. Johnson, Lisa De La Rosa, Giuseppina F. Dusio, Jeffrey B. Michel
Publikováno v:
The American journal of cardiology
Cardiac myosin binding protein-C (cMyBP-C) is a heart muscle-specific thick filament protein. Elevated level of serum cMyBP-C is an indicator of early myocardial infarction (MI), but its value as a predictor of future cardiovascular disease is unknow
Autor:
Jerome P. Trzeciakowski, William C. Hunter, Nancy L. Sehgel, Zhongkui Hong, Yi Zhu, Stephen F. Vatner, Zhe Sun, Dorothy E. Vatner, Gerald A. Meininger
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H1281-H1287
Increased vascular stiffness is fundamental to hypertension, and its complications, including atherosclerosis, suggest that therapy should also be directed at vascular stiffness, rather than just the regulation of peripheral vascular resistance. It i
Autor:
Fernando V. Lobo Ladd, Jerome P. Trzeciakowski, M. Engholm, Ming Yang, Ulrich Pohl, Lunyin Yu, Julian Kirsch, James S.K. Sham, Christina Mogensen, Grażyna Chwatko, Charles A. Hales, Andrew M. Kahn, Anita Umesh, Druck Reinhardt Druck Basel, Satz Mengensatzproduktion, Lucy Liaw, Allen C. Myers, Maria Tereza Jordão, Michael J. Mulvany, Ashkan Eftekhari, Antonio A. Coppi, Omkar Paudel, Calvin P.H. Vary, Theres Hennig, Torsten Gloe, Yuan-Ning Cao, Yuefeng Tang, Lisete Compagno Michelini, Edward Bald, Xuehui Yang, Jay D. Humphrey, Robert Friesel, Heather N. Hayenga, Renato Paulo Chopard, Andreea Trache
Publikováno v:
Journal of Vascular Research. 48:I-IV
Publikováno v:
Journal of Vascular Research. 48:495-504
Elucidating regional material properties of arterial tissue is fundamental to predicting transmural stresses and understanding how tissue stiffness influences cellular responses and vice versa. Atomic force microscopy (AFM) was used to measure point-
Autor:
Hongyu Qiu, Guy M. Genin, Stephen F. Vatner, Zhe Sun, Jerome P. Trzeciakowski, Christophe Depre, Filipinas F. Natividad, Yi Zhu, Elliot L. Elson, Gerald A. Meininger, Meredith Gansner, William C. Hunter, Dorothy E. Vatner, Ranillo R.G. Resuello
Publikováno v:
Circulation Research. 107:615-619
Rationale: Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM). Objective: We tested the hypothesis th
Autor:
Qianxing Mo, Jay D. Humphrey, Marina Vannucci, Jin Jia Hu, Natasa Popovic, Theresa W. Fossum, Emily Wilson, Eric A. Bridenbaugh, Matthew W. Miller, Jerome P. Trzeciakowski, Jessemy D. Neiger
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H2044-H2053
A porcine aortic coarctation model was used to examine regulation of gene expression in early hypertensive vascular remodeling. Aortic segments were collected proximal (high pressure) and distal (low pressure) to the coarctation after 2 wk of sustain
Autor:
Gerald A. Meininger, Zhongkui Hong, Jerome P. Trzeciakowski, Zhaohui Li, Walatta-Tseyon Mesquitta, Zhe Sun
Aims The regulation of vascular diameter by vasoconstrictors and vasodilators requires that vascular smooth muscle cells (VSMCs) be physically coupled to extracellular matrix (ECM) and neighbouring cells in order for a vessel to mechanically function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef1edde1b3ded31115a9841ad36f0d6
https://europepmc.org/articles/PMC3584957/
https://europepmc.org/articles/PMC3584957/
Autor:
Xin Wu, Gerald A. Meininger, Andrea M. Foskett, Zhe Sun, Mariappan Muthuchamy, Jerome P. Trzeciakowski
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 298(6)
Integrins link the extracellular matrix (ECM) with the intracellular cytoskeleton and other cell adhesion-associated signaling proteins to function as mechanotransducers. However, direct quantitative measurements of the cardiomyocyte mechanical state
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 258:H1032-H1041
Relative contributions of local autoregulatory tone and vasoconstrictor tone to skeletal muscle vascular resistance were studied in anesthetized rats during hypertension produced by vasoconstrictor infusion. Rats were instrumented with a Doppler flow