Zobrazeno 1 - 9
of 9
pro vyhledávání: '"William C. Hunter"'
Publikováno v:
Circulation. 86:1945-1954
BACKGROUND Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat. The additional amount of oxygen that is consumed by the heart to cycle this additional Ca2+ is believed to reduce myocard
Publikováno v:
Journal of Molecular and Cellular Cardiology. 24:783-797
The agent 2,3-butanedione monoxime (BDM) has been reported to reduce the sensitivity of myofilament force development to calcium ions, without affecting the calcium transient in myocardium. One would predict, therefore, that BDM should reduce the con
Autor:
S Bier, D. Burkhoff, William C. Hunter, Matthew R. Wolff, David A. Kass, Y Harasawa, Gary Gerstenblith, P. P. De Tombe
Publikováno v:
Circulation Research. 70:516-529
The contributions of changes in primary systolic and diastolic properties, limitations of contractile reserve, and alterations in energy efficiency to the left ventricular dysfunction seen with chronic pacing tachycardia were investigated. Seven dogs
Publikováno v:
The American journal of physiology. 265(3 Pt 2)
This study focuses on elucidating how ventricular afterloading conditions affect the time course of change of left ventricular pressure (LVP) throughout the cardiac cycle, with particular emphasis on revealing specific limitations in the time-varying
Publikováno v:
Circulation research. 71(2)
Myocardial oxygen consumption (MVO2) includes components for 1) mechanical energy generation, 2) activation, and 3) basal metabolism. Whereas the first two components are expected to increase in proportion with heart rate, a significant basal level o
Publikováno v:
Circulation. 73:938-950
Dimension change measures of regional ventricular function, such as absolute or percent wall thickening (delta T or % delta T) or segmental shortening (delta L or % delta L), are highly load dependent. In 16 anesthetized mongrel dogs we assessed use
Publikováno v:
Journal of Molecular and Cellular Cardiology. 20:415-426
To determine whether catecholamines produce alterations in myocardial myosin-actin cycling kinetics, we investigated the effects of isoproterenol upon mechanical characteristics of constantly activated heart muscle thought to reflect crossbridge beha
Publikováno v:
Circulation. 72:654-659
Although the rate dependence of isolated muscle contractility is well known, the ventricular end-systolic pressure-volume relationship (ESPVR) has been reported to be insensitive to heart rate. To resolve this contradiction, we used an isolated, ejec
Publikováno v:
Circulation Research. 56:340-350
We established, for the isolated, isovolumically beating canine left ventricle, a comprehensive description of postextrasystolic contractile strength (dP/dtmax) as a function of extrasystolic and postextrasystolic stimulus intervals. In contrast to p