Zobrazeno 1 - 10
of 17
pro vyhledávání: '"William C. Hunter"'
Autor:
Hongyu Qiu, Guy M. Genin, Stephen F. Vatner, Zhe Sun, Jerome P. Trzeciakowski, Christophe Depre, Filipinas F. Natividad, Yi Zhu, Elliot L. Elson, Gerald A. Meininger, Meredith Gansner, William C. Hunter, Dorothy E. Vatner, Ranillo R.G. Resuello
Publikováno v:
Circulation Research. 107:615-619
Rationale: Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM). Objective: We tested the hypothesis th
Autor:
William C. Hunter
Publikováno v:
Cardiology Clinics. 18:443-457
Myocardial relaxation is governed by the interplay of two macromolecular systems: (1) myofilaments and (2) calcium extruding pumps/exchangers. In myocardium from failing hearts, both systems act more slowly than normal, and cause relaxation to decele
Publikováno v:
Europe PubMed Central
Length-dependent steady-state and dynamic responses of five models of isometric force generation in cardiac myofilaments were compared with similar experimental data from the literature. The models were constructed by assuming different subsets of th
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 264:H1817-H1824
Recent clinical and animal studies have suggested that ventricular-vascular coupling normally operates at either optimal ventricular efficiency (EFF = stroke work/myocardial oxygen consumption) or stroke work (SW) and that efficiency in particular is
Publikováno v:
Circulation. 86:1945-1954
BACKGROUND Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat. The additional amount of oxygen that is consumed by the heart to cycle this additional Ca2+ is believed to reduce myocard
Publikováno v:
Journal of Molecular and Cellular Cardiology. 24:783-797
The agent 2,3-butanedione monoxime (BDM) has been reported to reduce the sensitivity of myofilament force development to calcium ions, without affecting the calcium transient in myocardium. One would predict, therefore, that BDM should reduce the con
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H1013-H1024
We present a mechanical assay for estimating the time course of Ca2+ bound to low-affinity sites on troponin C (TnC) in twitching rabbit papillary muscle. The assay is based on a theoretical correlation between the rate of force redevelopment after d
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H569-H578
Recent studies have shown that at the same endsystolic volume, ejecting beats can achieve a higher end-systolic pressure than isovolumic beats. The purpose of this study was to assess the metabolic cost, in terms of oxygen consumption (MVO2), and eff
Autor:
Paul M.L. Janssen, William C. Hunter
Publikováno v:
The American journal of physiology. 269(2 Pt 2)
Recent studies have emphasized the importance of the late systolic phase for understanding ventricular ejection. To examine the myocardial factors controlling this phase, we studied the timing of twitch contraction in nine excised rat trabeculae cont
Publikováno v:
The American journal of physiology. 260(4 Pt 2)
To determine the dynamic property of cardiac function response to alterations in coronary perfusion, we varied coronary arterial pressure (CAP) sinusoidally around one of four mean CAP levels with a constant amplitude at several frequencies in isolat