Zobrazeno 1 - 5
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pro vyhledávání: '"William C. Hunter"'
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H1013-H1024
We present a mechanical assay for estimating the time course of Ca2+ bound to low-affinity sites on troponin C (TnC) in twitching rabbit papillary muscle. The assay is based on a theoretical correlation between the rate of force redevelopment after d
Publikováno v:
The American journal of physiology. 259(5 Pt 2)
Barium contracture tonically activates myocardium while preserving cellular integrity. We studied the metabolic and mechanical consequences of sustained Ba2+ contracture. We measured the time course of phosphocreatine (PCr), ATP, Pi, total phosphate,
Autor:
William C. Hunter
Publikováno v:
Circulation Research. 64:265-275
Ejection has previously been thought to exert only negative effects on end-systolic left ventricular pressure, via mechanisms like shortening deactivation and the force-velocity relation. Whether ejection also exerted a positive influence on pressure
Publikováno v:
Circulation research. 64(2)
We studied the effect of ejection on end-systolic pressure in isolated heart preparations. Ejecting beats were compared with isovolumic beats having the same volume as at end systole. While holding end-systolic volume constant, various stroke volumes
Publikováno v:
The American journal of physiology. 246(1 Pt 2)
We measured cardiac mechanical restitution curves, which describe the time course of recovery of ventricular contractile strength following a steady-state beat. In the first series of experiments, we studied left ventricles that beat isovolumically t