Zobrazeno 1 - 6
of 6
pro vyhledávání: '"William C. Hunter"'
Autor:
Hongyu Qiu, Guy M. Genin, Stephen F. Vatner, Zhe Sun, Jerome P. Trzeciakowski, Christophe Depre, Filipinas F. Natividad, Yi Zhu, Elliot L. Elson, Gerald A. Meininger, Meredith Gansner, William C. Hunter, Dorothy E. Vatner, Ranillo R.G. Resuello
Publikováno v:
Circulation Research. 107:615-619
Rationale: Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM). Objective: We tested the hypothesis th
Publikováno v:
Circulation. 86:1945-1954
BACKGROUND Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat. The additional amount of oxygen that is consumed by the heart to cycle this additional Ca2+ is believed to reduce myocard
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H1013-H1024
We present a mechanical assay for estimating the time course of Ca2+ bound to low-affinity sites on troponin C (TnC) in twitching rabbit papillary muscle. The assay is based on a theoretical correlation between the rate of force redevelopment after d
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 260:H569-H578
Recent studies have shown that at the same endsystolic volume, ejecting beats can achieve a higher end-systolic pressure than isovolumic beats. The purpose of this study was to assess the metabolic cost, in terms of oxygen consumption (MVO2), and eff
Publikováno v:
The American journal of physiology. 259(5 Pt 2)
Barium contracture tonically activates myocardium while preserving cellular integrity. We studied the metabolic and mechanical consequences of sustained Ba2+ contracture. We measured the time course of phosphocreatine (PCr), ATP, Pi, total phosphate,
Publikováno v:
Journal of Molecular and Cellular Cardiology. 20:415-426
To determine whether catecholamines produce alterations in myocardial myosin-actin cycling kinetics, we investigated the effects of isoproterenol upon mechanical characteristics of constantly activated heart muscle thought to reflect crossbridge beha