Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thre
Autor:
Fatemeh Momen-Heravi, Hiroshi Nakagawa, Satoshi Takada, Veena Sangwan, Norihiro Matsuura, Andres J. Klein-Szanto, Angela J. Yoon, Koji Tanaka, Samuel Flashner, Uma M. Sachdeva, Lorenzo E. Ferri, Masataka Shimonosono, Eishi Noguchi, J. Alan Diehl, Yasuto Tomita
Publikováno v:
Biomolecules, Vol 11, Iss 1479, p 1479 (2021)
Biomolecules
Volume 11
Issue 10
Biomolecules
Volume 11
Issue 10
Background: Alcohol (ethanol) consumption is a major risk factor for head and neck and esophageal squamous cell carcinomas (SCCs). However, how ethanol (EtOH) affects SCC homeostasis is incompletely understood. Methods: We utilized three-dimensional
Autor:
Koji Tanaka, Yoshiaki Kita, Jeffrey D. Winkler, Andres J. Klein-Szanto, Douglas S. Darling, Hiroshi Nakagawa, Satish Srinivasan, Manti Guha, Anil K. Rustgi, Ravi K. Amaravadi, Narayan G. Avadhani, Kelly A. Whelan, Mitsuteru Natsuizaka, Prasanna M. Chandramouleeswaran, Shoji Natsugoe
Publikováno v:
Oncogene
High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient out
Autor:
Ashley A. Lento, Hiroshi Nakagawa, Kensuke Suzuki, Qiaosi Tang, Mirazul Islam, Adam J. Bass, Anil K. Rustgi, Veronique Giroux, Gizem Efe, Apple Long, E. Paul Wileyto, Tatiana A. Karakasheva, Andres J. Klein-Szanto
Publikováno v:
EMBO Rep
Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer worldwide. The most commonly mutated gene in ESCC is TP53. Using a combinatorial genetic and carcinogenic approach, we generate a novel mouse model of ESCC expr
Autor:
Kathryn E. Hamilton, Koji Tanaka, Veronique Giroux, Hiroshi Nakagawa, Marie Pier Tetreault, Ju Seog Lee, Apple Long, Andres J. Klein-Szanto, Anil K. Rustgi, Kelly A. Whelan
Publikováno v:
Carcinogenesis. 36:598-606
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We h
Autor:
Jennifer N. Koch, Kathy Q. Cai, David Campbell, J. Silvio Gutkind, Klaus P. Hoeflich, Jonathan Chernoff, Sergio G. Durón, Marie O'Farrell, Dina Stepanova, Zahara M. Jaffer, Andres J. Klein-Szanto, Hoi Yee Chow, Adrian M. Jubb
Publikováno v:
Cancer Research. 72:5966-5975
The RAS genes are the most commonly mutated oncogenes in human cancer and present a particular therapeutic dilemma, as direct targeting of Ras proteins by small molecules has proved difficult. Signaling pathways downstream of Ras, in particular Raf/M
Autor:
Daniel E. Bassi, Tianyu Li, Emmanuelle Nicolas, Jirong Zhang, Andres J. Klein-Szanto, Jian Fu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 4, Pp 271-282 (2012)
Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression. In vitro studies using cancer cell lines and clini
Autor:
Andres J. Klein-Szanto, Harry Subramanian, Shingo Kagawa, Azal Ahmadi, Shinya Ohashi, Hiroshi Nakagawa, Seiji Naganuma, Kei J. Nakagawa, Xinjun Ji, Stephen A. Liebhaber, Mitsuteru Natsuizaka, Sanders Chang
Publikováno v:
The FASEB Journal. 26:2620-2630
Insulin-like growth factor binding protein (IGFBP)-3 regulates cell proliferation and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. We have investigated how the hypoxic tumor microenvironment in ESCC fosters the induction of IGFBP3. R
Autor:
Shinya Ohashi, Mitsuteru Natsuizaka, Ross A. Kalman, Phyllis A. Gimotty, Andres J. Klein-Szanto, Seiji Naganuma, Momo Nakagawa, Douglas S. Darling, Meenhard Herlyn, Sotai Kimura, Hiroshi Itoh, Shingo Kagawa, J. Alan Diehl, Hiroshi Nakagawa, Devraj Basu
Publikováno v:
Cancer Research. 71:6836-6847
Zinc finger E-box–binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in TGF-β–mediated senescence, epithelial-to-mesenchymal transition (EMT), and cancer stem cell functions. ZEBs are negatively regulated by members of the
Autor:
Ekaterina G. Shatalova, Andres J. Klein-Szanto, Edna Cukierman, Karthik Devarajan, Margie L. Clapper
Publikováno v:
Cancer Prevention Research. 4:107-115
Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States. The goal of this study was to evaluate the contribution of estrogens to the development of HNSCCs. Various cell lines derived from earl