Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Chiu AP; Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China., Tschida BR; Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China., Lo LH; Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China., Moriarity BS; Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China., Rowlands DK; Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China., Largaespada DA; Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China., Keng VW; Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Publikováno v:
World journal of gastroenterology [World J Gastroenterol] 2015 Nov 14; Vol. 21 (42), pp. 12157-70.
Autor:
Eunice Y. Lau, Man Tong, Katherine Po Sin Chung, Terence K. Lee, Stephanie Ma, Rainbow Wing Hei Leung, Etienne H. Mok, Irene Oi-Lin Ng, Martina Mang Leng Lei, Q Zhao, Vincent W. Keng, Carmen Oi Ning Leung, Hoi Wing Leung, Cong Ma
Publikováno v:
Cancer Research. 81:3229-3240
The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) is a possible way to reverse drug resistance, however, inhibitors that spec
Publikováno v:
Biochemical and Biophysical Research Communications. 541:70-77
A forward genetic Sleeping Beauty (SB) insertional mutagenesis screen, followed by high-throughput transcriptome sequencing, was used to identify driver genes responsible for hepatocellular carcinoma (HCC)-associated metastasis. Using RNA-sequencing
Autor:
Adam J. Dupuy, Barbara R. Tschida, Vincent W. Keng, David A. Largaespada, Khalid Amin, Christopher S. Stipp, Pauline J. Beckmann, Charlotte R. Feddersen, Michael A. Linden, Jesse D. Riordan
Most hepatocellular carcinomas (HCCs) develop in a chronically injured liver, yet the extent to which this microenvironment promotes neoplastic transformation or influences selective pressures for genetic drivers of HCC remains unclear. We sought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e536d52d60f1ab77cc1c53064e4ec808
https://europepmc.org/articles/PMC5826818/
https://europepmc.org/articles/PMC5826818/
Publikováno v:
Hepatology. 53:781-790
The mechanisms associated with hepatitis B virus (HBV)–induced hepatocellular carcinoma (HCC) remain elusive, and there are currently no well-established animal models for studying this disease. Using the Sleeping Beauty transposon as a delivery sy
Autor:
Takashi Tanaka, Kazuya Yamada, Ayuko Sato, Tamio Noguchi, Makiyo Hinata, Eri Kikkawa, Vincent W. Keng, Zaw Myint
Publikováno v:
Journal of Biochemistry. 130:885-891
The 5'-flanking region of the mouse Hex gene was examined in order to identify transcription factors regulating its expression in hepatocytes and haematopoietic cells. We have identified two further GC boxes (GC boxes 3 and 4 at nucleotide positions
Autor:
David A. Largaespada, Manel Solé, Kevin A. T. Silverstein, Branden S. Moriarity, Danhua Fan, Timothy P. Kuka, Augusto Villanueva, Jason B. Bell, Aaron L. Sarver, Adam J. Dupuy, Wai L. Lee, Jesse D. Riordan, Barbara R. Tschida, Clara Alsinet, Josep M. Llovet, Daniela Sia, Vincent W. Keng
Hepatocellular carcinoma (HCC) is one of the deadliest solid cancers and is the third leading cause of cancer-related death. There is a universal estimated male/female ratio of 2.5, but the reason for this is not well understood. The Sleeping Beauty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16449023f957a44d7127de5bb72cd1c9
https://europepmc.org/articles/PMC3511635/
https://europepmc.org/articles/PMC3511635/
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer
Autor:
Jef D. Boeke, Wei Rose Xie, Erin L. Reineke, Bert W. O'Malley, David A. Largaespada, Vincent W. Keng, Loris Mularoni, Michael Torbenson, Danhua Fan, Kathryn A. O'Donnell, Sarah J. Wheelan, Brian York, Kevin A. T. Silverstein, Christina T. Schrum, Daekwan Seo
The Sleeping Beauty ( SB ) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC , one of the most commonly d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd78fe674776140ab4f45b3df0b55f4d
https://europepmc.org/articles/PMC3361419/
https://europepmc.org/articles/PMC3361419/
Autor:
Aaron L. Sarver, Neal G. Copeland, Lara S. Collier, Lino Tessarollo, Nancy A. Jenkins, Ilze Matise, Adam J. Dupuy, Vincent W. Keng, Derek Y. Chiang, Timothy K. Starr, David A. Largaespada, Keiko Akagi, Josep M. Llovet, Kevin A. T. Silverstein, Augusto Villanueva, Scott W. Lowe, Scott Powers, Barbara J. Ryan
Publikováno v:
Nature biotechnology. 27(3)
We describe a system that permits conditional mobilization of a Sleeping Beauty (SB) transposase allele by Cre recombinase to induce cancer specifically in a tissue of interest. To demonstrate its potential for developing tissue-specific models of ca
Autor:
Lilian H. Lo, David A. Largaespada, Barbara R. Tschida, Amy P. Chiu, Dewi K Rowlands, Branden S. Moriarity, Vincent W. Keng
Publikováno v:
World Journal of Gastroenterology. 21:12157
The major type of human liver cancer is hepatocellular carcinoma (HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepat