Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Andreas Villunger"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10883, p 10883 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
P53 is known as the most critical tumor suppressor and is often referred to as the guardian of our genome. More than 40 years after its discovery, we are still struggling to understand all molecular details on how this transcription factor prevents o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905cb17103a7ee262f927af22ac4c3d5
Autor:
Laura Bongiovanni, Kaoru Tsuchia, Tatjana Stojakovic, Katja Knapp, Vincent Zoran Braun, Hubert Scharnagl, Nataliya Rohr-Udilova, Georg Semmler, Floris Foijer, Gerald Timelthaler, Andreas Villunger, Matthias Pinter, Alain de Bruin, Tamas G. Szabo, Diana C.J. Spierings, Bart Westendorp, Valentina C. Sladky, Thomas Reiberger, Ana Curinha, Hilda van den Bos
Publikováno v:
EMBO Rep
EMBO Reports, 21, 1. Nature Publishing Group
EMBO Reports
EMBO reports
Embo Reports, 21(12):50893. Wiley
EMBO Reports, 21, 1. Nature Publishing Group
EMBO Reports
EMBO reports
Embo Reports, 21(12):50893. Wiley
Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. This multi‐protein complex is activated by supern
Autor:
Thomas Reiberger, Laura Bongiovanni, Matthias Pinter, Kaoru Tsuchia, Tatjana Stojakovic, Katja Knapp, Bart Westendorp, Diana C.J. Spierings, Valentina C. Sladky, Alain de Bruin, Gerald Timelthaler, Hubert Scharnagl, Floris Foijer, Hilda van den Bos, Andreas Villunger, Tamas G. Szabo, Nataliya Rohr-Udilova
Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. The PIDDosome multi-protein complex is activated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45379e9ca3eaf137417703b487fb7540
https://doi.org/10.1101/2020.05.13.092486
https://doi.org/10.1101/2020.05.13.092486
Autor:
André C. Mueller, Stefan Kubicek, Benjamin L. Ebert, Reinhard Grausenburger, Markus Zojer, Veronika Sexl, Gerwin Heller, Anca-Sarmiza Tigan, Claus Vogl, Marlies Dolezal, Karoline Kollmann, Johannes Zuber, Iris Z. Uras, Svenja Hartenberger, Alexander Höllein, Donna Neuberg, Sebastian Kollmann, Marcos Malumbres, Joanna I. Loizou, Eszter Doma, Andreas Villunger, Michaela Prchal-Murphy, Anna Ringler, Florian Bellutti, Sofie Nebenfuehr, Matthias Farlik, Philip W. Hinds
Publikováno v:
Cancer Discovery
Tumor formation is a multi-step process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a stage-specific
Autor:
Giulio Loforese, Tatiana Rabachini, Simone Wicki, Thomas Kaufmann, Deborah Stroka, Zhaoyue He, Valentina C. Sladky, Andreas Villunger, Yuniel Fernández-Marrero, Daniel Bachmann, Matteo Montani
Publikováno v:
Rabachini de Almeida, Tatiana; Fernández Marrero, Yuniel; Montani, Matteo; Loforese, Giulio; Sladky, Valentina; He, Zhaoyue; Bachmann, Daniel; Wicki, Simone; Villunger, Andreas; Keogh-Stroka, Deborah M.; Kaufmann, Thomas (2018). BOK promotes chemical-induced hepatocarcinogenesis in mice. Cell death and differentiation, 25(4), pp. 706-718. Nature Publishing Group 10.1038/s41418-017-0008-0
BCL-2-related ovarian killer (BOK) is a conserved and widely expressed BCL-2 family member with sequence homology to pro-apoptotic BAX and BAK, but with poorly understood pathophysiological function. Since several members of the BCL-2 family are crit
Autor:
Fabian Schuler, Johannes G. Weiss, Silke E. Lindner, Michael Lohmüller, Sebastian Herzog, Simon F. Spiegl, Philipp Menke, Stephan Geley, Verena Labi, Andreas Villunger
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression in response to DNA damage. Despite its essential function, CHK1 has been identified as a target to kill cancer cells and studies using
Autor:
Lukas Peintner, Gerhard Krumschnabel, Florian J. Bock, Gottfried Baier, Maria C. Tanzer, Claudia Manzl, Andreas Villunger, Natascha Hermann-Kleiter, Laura Llacuna, José Yélamos
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation; Vol 20
Cell Death and Differentiation; Vol 20
Activation of NF-κB (nuclear factor of kappa light chain gene enhancer in B cells) in response to DNA damage is considered to contribute to repair of genetic lesions, increased cell survival and cytokine release. The molecular mechanisms orchestrati
Autor:
Denise Tischner, Eleonora Ottina, Claudia Soratroi, Holger M. Reichardt, Francesca Grespi, Andreas Ploner, Stephan Geley, Andreas Villunger, Marco J Herold
Publikováno v:
Blood. 119:6032-6042
Gene-targeting studies in mice have identified the essential roles of most prosurvival Bcl-2 family members in normal physiology and under conditions of stress. The function of one member, Bcl2a1/Bfl-1/A1, is only poorly understood because of quadrup
Autor:
Andrea Newbold, Mathias Drach, Gerhard Krumschnabel, Lukas Peintner, Florian J. Bock, Claudia Manzl, Andreas Villunger, Ricky W. Johnstone, Verena Labi
Publikováno v:
Cell Death and Differentiation
The PIDDosome, a multiprotein complex constituted of the 'p53-induced protein with a death domain (PIDD), 'receptor-interacting protein (RIP)-associated ICH-1/CED-3 homologous protein with a death domain' (RAIDD) and pro-Caspase-2 has been defined as
Autor:
Andreas Villunger, Verena Labi
Publikováno v:
Cell Cycle. 9:4269-4275
Several recent studies provided evidence that PUMA, a pro-apoptotic member of the BH3-only protein subgroup of the Bcl-2 family, is critical for restricting survival and recovery of different cell types, including those of the hematopoietic system, a