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pro vyhledávání: '"Joel R. Leininger"'
Publikováno v:
Toxicology and Applied Pharmacology. 148:137-147
Chloroform (TCM), a water disinfection by-product, induced liver tumors in female mice when administered by gavage in corn oil but not when given in drinking water at comparable daily doses. Because short-term studies showed that the gavage doses als
Autor:
Stephane Mery, Brian A. Wong, Michael V. Templin, Byron E. Butterworth, Joel R. Leininger, Jeffrey L. Larson, Kevin T. Morgan, Douglas C. Wolf, Keith C. Jamison
Publikováno v:
Toxicological Sciences. 32:109-125
Chloroform acts via a nongenotoxic–cytotoxic mode of action to produce cancer if given in doses and at dose rates sufficiently high to produce organ-specific toxicity. In a recent study, chloroform failed to induce cancer in male or female F-344 ra