Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Daniel S. Marsman"'
Autor:
Brian G. Lake, John G. DeLuca, Walter Wahli, Daniel S. Marsman, Timothy A. Pastoor, Penelope A. Fenner-Crisp, Russell C. Cattley, Jonathan Tugwood, Bernard A. Schwetz, Cliff Elcombe, Denise Robinson, James A. Popp
Publikováno v:
Regulatory Toxicology and Pharmacology. 27:47-60
The purpose of the workshop "Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?" was to provide a review of the current state of the science on the relationship between peroxisome proliferation and hepatocarcinogenesis.
Publikováno v:
Carcinogenesis. 16:77-82
Transforming growth factor alpha (TGF alpha) is a mitogenic growth factor for hepatocytes that may play a role in the development of liver cancer in rodents and humans. Epidermal growth factor receptor (EGFR) is the receptor for TGF alpha; its expres
Autor:
Daniel S. Marsman, James A. Popp
Publikováno v:
Carcinogenesis. 15:111-117
The biological potential of hepatic foci and tumors induced by peroxisome proliferators such as Wy-14,643 has been poorly characterized. In this study, male F-344 rats (n = 20/group/time point) were fed Wy-14,643 (0.1%) for 22, 37 or 52 weeks ('W-22'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1102:237-244
A number of plasticizers and lipid-lowering drugs induce peroxisomes and cause hepatocellular carcinoma in rodents by mechanisms which remain unknown. In this study, seven structurally dissimilar peroxisome proliferating agents were shown to uncouple
Publikováno v:
Fundamental and Applied Toxicology. 18:149-154
The dose and time dependency of peroxisome proliferation and hepatocyte replication was evaluated in the liver of rats fed the peroxisome proliferator and hepatocarcinogen, Wy-14,643. Male F344 rats were fed NIH07 diet blended with Wy-14,643 at 0, 5,
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 27(2)
o-Benzyl-p-chlorophenol, an aryl halide biocide, was evaluated in male and female F344/N rats and B6C3F1 mice in a series of subchronic and 2-year toxicity and carcinogenicity studies. Kidney was the primary target of toxicity in the 13-week gavage s
Publikováno v:
Carcinogenesis. 13(6)
Earlier studies indicated that the hepatocarcinogenic activity of two peroxisome proliferators (PP) Wy-14,643 and di(2-ethylhexyl)phthalate (DEHP) correlated to the degree of lipofuscin accumulation and sustained cell replication rather than the leve
Publikováno v:
Carcinogenesis. 12(3)
The carcinogenicity of the peroxisome proliferator WY-14,643 was compared in young (starting age 2 months) and old (starting age 15 months) rats. Old rats had a 5- to 7-fold higher yield of grossly visible hepatic tumors following 22 weeks of dietary
Autor:
James A. Popp, Daniel S. Marsman, Konrad E. Tomaszewski, Russell C. Cattley, Michael J. Olson, James G. Conway
Publikováno v:
Carcinogenesis. 10:513-519
Quantitative comparisons of the time course of biochemical and morphological changes induced by peroxisome proliferators resulting in low and high incidences of hepatic cancer have not been conducted previously under bioassay conditions. [4-Chloro-6-
Publikováno v:
Toxicology. 56:1-7
The ability of the peroxisome proliferator WY-14,643 to act as an initiator of hepatocarcinogenesis was examined using a modified growth-selection protocol in rats. Feeding rats 0.1% WY-14,643 in the diet for 3 weeks, coupled with partial hepatectomy