Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marcello Solinas"'
Publikováno v:
British Journal of Pharmacology. 154:369-383
Food, drugs and brain stimulation can serve as strong rewarding stimuli and are all believed to activate common brain circuits that evolved in mammals to favour fitness and survival. For decades, endogenous dopaminergic and opioid systems have been c
Publikováno v:
Pharmacological Research
Pharmacological Research, Elsevier, 2007, 56 (5), pp.393-405. ⟨10.1016/j.phrs.2007.09.005⟩
Pharmacological Research, Elsevier, 2007, 56 (5), pp.393-405. ⟨10.1016/j.phrs.2007.09.005⟩
(IF : 3,287); International audience; Cannabis is the most commonly abused illegal drug in the world and its main psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), produces rewarding effects in humans and non-human primates. Over the last
Autor:
Walter Fratta, Maria Scherma, Gianluigi Tanda, Jessica Stroik, Liana Fattore, Steven R. Goldberg, Marcello Solinas, Carrie Wertheim
Publikováno v:
Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2007, 27 (21), pp.5615-5620. ⟨10.1523/JNEUROSCI.0027-07.2007⟩
Journal of Neuroscience, Society for Neuroscience, 2007, 27 (21), pp.5615-5620. ⟨10.1523/JNEUROSCI.0027-07.2007⟩
Increasing use of cannabis makes the search for medications to reduce cannabis abuse extremely important. Here, we show that homomeric α7nicotinic receptors are novel molecular entities that could be targeted in the development of new drugs for the
Autor:
Carrie E. Wertheim, Sevil Yasar, Subramanian K. Vadivel, Zuzana Justinova, Alexandros Makriyannis, Gianluigi Tanda, Marcello Solinas, Steven R. Goldberg, Daniele Piomelli
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 321 (1), pp.370-380. ⟨10.1124/jpet.106.114124⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 321 (1), pp.370-380. ⟨10.1124/jpet.106.114124⟩
(IF : 4,003); International audience; Anandamide is an endogenous ligand for brain cannabinoid CB(1) receptors, but its behavioral effects are difficult to measure due to rapid inactivation. Here we used a drug-discrimination procedure to test the hy
Autor:
Nathalie Thiriet, Céline Nicolas, Virginie Lardeux, Marcello Solinas, Claudia Chauvet, Andrea Duranti
Publikováno v:
International Journal of Neuropsychopharmacology
International Journal of Neuropsychopharmacology, Oxford University Press (OUP), 2015, 18 (1), ⟨10.1093/ijnp/pyu025⟩
International Journal of Neuropsychopharmacology, Oxford University Press (OUP), 2015, 18 (1), ⟨10.1093/ijnp/pyu025⟩
Background: The endogenous cannabinoid system plays an important role in motivation, stress, and drug abuse. Pharmacologically, the endocannabinoid system can be stimulated by either agonists of CB1 receptors or inhibition of metabolic degradation of
Publikováno v:
Journal of Neuroscience. 25:5645-5650
Anandamide, an endogenous ligand for brain cannabinoid CB(1) receptors, produces many behavioral effects similar to those of Delta(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana. Reinforcing effects of THC have been demo
Autor:
Gianluigi Tanda, Stephanie A Matthews, Alexandros Makriyannis, Leigh V. Panlilio, Marcello Solinas, Steven R. Goldberg
Publikováno v:
Neuropsychopharmacology. 30:2046-2057
Accumulating evidence suggests that the endogenous cannabinoid system is involved in the reinforcing effects of heroin. In rats intravenously self-administering heroin, we investigated effects of cannabinoid CB1 receptor agonists and compounds that b
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:93-102
Activation or blockade of cannabinoid CB1 receptors markedly alters many effects of opioids. In the present study, we investigated whether the cannabinoid antagonist (N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxam
Autor:
Benjamin Gennequin, Cinzia Rapino, Maureen Francheteau, Nathalie Thiriet, Mauro Maccarrone, Joëlle Nader, Alexandros Makriyannis, Andrea Duranti, Marcello Solinas, François Chavant
Publikováno v:
Neuropharmacology
Neuropharmacology, Elsevier, 2014, 87, pp.214-221. ⟨10.1016/j.neuropharm.2014.03.014⟩
Neuropharmacology, Elsevier, 2014, 87, pp.214-221. ⟨10.1016/j.neuropharm.2014.03.014⟩
Methamphetamine toxicity is associated with cell death and loss of dopamine neuron terminals in the striatum similar to what is found in some neurodegenerative diseases. Conversely, the endocannabinoid system (ECS) has been suggested to be neuroprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54df32667c76e02df7578a653ac9712c
https://europepmc.org/articles/PMC4939842/
https://europepmc.org/articles/PMC4939842/
Publikováno v:
Neuropharmacology. 63(1)
Cannabinoid receptor agonists are known to stimulate feeding in humans and animals and this effect is thought to be related to an increase in food palatability. On the other hand, highly palatable food stimulates dopamine (DA) transmission in the she