Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Xiaorui Zhang"'
Autor:
Joseph D. Khoury, Prerna Malaney, Courtney D. DiNardo, Bing Z. Carter, Lauren B Ostermann, Michael Andreeff, Ryohei Kozaki, Xiaorui Zhang, Marina Konopleva, Sean M. Post, Marisa J.L. Aitken, Peter P. Ruvolo, Huaxian Ma, Vivian Ruvolo, Tomoko Yasuhiro, Po Yee Mak, Lauren E. Chan
Publikováno v:
Haematologica. 107:1311-1322
FMS-like Tyrosine Kinase 3 (FLT3) mutation is associated with poor survival in acute myeloid leukemia (AML). The specific Anexelekto/MER Tyrosine Kinase (AXL) inhibitor, ONO-7475, kills FLT3-mutant AML cells with targets including Extracellular- sign
Autor:
Pengzhao Shang, Yang Wang, Juan Zhang, Minji Guo, Zhu Yijia, Hui Peng, Xiaorui Zhang, Gao Rui, Min Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 420-433 (2021)
Although interferon α (IFNα) and anti-angiogenesis antibodies have shown appropriate clinical benefit in the treatment of malignant cancer, they are deficient in clinical applications. Previously, we described an anti-vascular endothelial growth fa
Autor:
Prerna Malaney, Xiaorui Zhang, Marisa J.L. Aitken, Miguel Gallardo, Lauren E. Chan, Pedro Aguilar-Garrido, Maria Velasco-Estevez, Sean M. Post
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
B-cell lymphomas are one of the most biologically and molecularly heterogeneous group of malignancies. The inherent complexity of this cancer subtype necessitates the development of appropriate animal model systems to characterize the disease with th
Autor:
Xiaorui Zhang, Todd M. Link, Vrutant Shah, Laura R. Pageon, Carlos E. Bueso-Ramos, Meng Han Wu, Sean M. Post, Huaxian Ma, Sanzhar Alybayev, Marisa J.L. Aitken, Miguel Gallardo, Joaquin Martinez-Lopez, Ken H. Young, Rodrigo Jacamo, Prerna Malaney, Li Yu, Dos D. Sarbassov, Inmaculada Rapado, Zijun Y. Xu-Monette, Michelle Craig Barton, Haley Steinman, Hun Ju Lee
Publikováno v:
J Natl Cancer Inst
Background Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein that is aberrantly expressed in cancers. We and others have previously shown that reduced hnRNP K expression downmodulates tumor-suppressive programs. However, o
Autor:
Todd M. Link, Clifford Stephan, Reid T. Powell, Kevin N. Dalby, Mary Sobieski, Eun Jeong Cho, Xiaorui Zhang, Marisa J.L. Aitken, Juan Cerda, Lauren Chan, Prerna Malaney, Nghi Nguyen, Sean M. Post
Publikováno v:
Blood. 138:2226-2226
hnRNP K (heterogeneous ribonucleoprotein K) is an RNA-binding protein that binds to conserved poly-C rich tracks in RNA and influences a diverse set of molecular pathways involved in tumorigenesis. Our previous studies identified hnRNP K overexpressi
Publikováno v:
Biochemical and Biophysical Research Communications. 493:1273-1279
Psychological stress has recently been described as a risk factor in the development of pancreatic cancer. Here, we reported that increased neurotransmitter adrenaline was associated with the poor survival in pancreatic cancer patients. Moreover, in
Autor:
Xiaorui Zhang, Michael Andreeff, Miguel Gallardo, Huaxian Ma, Peter P. Ruvolo, Wendy D. Schober, Joseph D. Khoury, Ivonne Hernandez, Vivian Ruvolo, Jorge E. Cortes, Sean M. Post, Hong Mu
Publikováno v:
Haematologica
Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine kinase anexelekto is critical for FMS-like tyrosine kinase 3 signaling and participates in FMS
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 20:S176-S177
Context Galectin 1 (LGALS1) participates in diverse survival pathways that support many pro-tumor molecules, especially those regulated by RAS. LGALS1 regulates hematopoietic cell differentiation, so it is not surprising that LGALS1 plays a role in m
Autor:
Zeev Estrov, Carlos E. Bueso-Ramos, Xiaorui Zhang, Ivo Veletic, Taghi Manshouri, Sean M. Post, Srdan Verstovsek, David Harris
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222912 (2019)
PLoS ONE
PLoS ONE
To confirm that neoplastic monocyte-derived collagen- and fibronectin-producing fibrocytes induce bone marrow (BM) fibrosis in primary myelofibrosis (PMF), we injected PMF BM-derived fibrocyte-precursor CD14+/CD34- monocytes into the tail vein of NOD
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1867:118785
The galectin LGALS1 is a glycan binding protein that regulates intracellular (e.g. signal transduction) and extracellular processes (e.g. immunity, leukocyte mobilization) that support cell survival. The protein is best known for its role in RAS sign