Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Shedden, A"'
Autor:
Zakiyah Niwaz, Maria Elena Cufari, Paulo Loureiro de Sousa, May Al Sahaf, Hema Chavan, George Ladas, Emma Beddow, Michael Dusmet, Niall McGonigle, Vladimir Anikin, Andrew G. Nicholson, Maria Leung, Lynn Shedden, Chiara Proli, Eric Lim, Simon Jordan, H. Raubenheimer
Publikováno v:
European Journal of Cancer. 84:55-59
Background Never-smokers with lung cancer often present late as there are no established aetiological risk factors. The aim of the study is to define the frequency over time and characterise clinical features of never-smokers presenting sufficiently
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 95(5):1378-1390
INTRODUCTION: Stereotactic body radiation therapy (SBRT) and Radiofrequency ablation (RFA) are two important treatment options for medically inoperable patients with stage I non-small cell lung cancer (NSCLC). Here we performed a systemic review and
Autor:
Sami N. Malek, Hongxiu Li, Mehmet Yildiz, Si�n Jones, Brian Parkin, Peter Ouillette, Mark S. Kaminski, Alfred E. Chang, Nisar A. Amin, Kamlai Saiya-Cork, Shaomeng Wang, Denzil Bernard, Kerby Shedden, Kathryn Jacobi
Publikováno v:
Blood. 125:668-679
Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performe
Autor:
Feng-Ming Spring Kong, Shuanghu Yuan, Theodore S. Lawrence, Xu-Wei Cai, James A. Hayman, Matthew H. Stenmark, Kerby Shedden, Timothy Ritter, Randall K. Ten Haken
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 84:e217-e222
Purpose To investigate the plasma dynamics of 5 proinflammatory/fibrogenic cytokines, including interleukin-1beta (IL-1β), IL-6, IL-8, tumor necrosis factor alpha (TNF-α), and transforming growth factor beta1 (TGF-β1) to ascertain their value in p
Autor:
Nisar A. Amin, Kamlai Saiya-Cork, Erlene K. Seymour, Kerby Shedden, Brian Parkin, Sami N. Malek
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(17)
Purpose: Chronic lymphocytic leukemia (CLL)-associated gene mutations that influence CLL cell fitness and chemotherapy resistance should increase in clonal representation when measured before therapy and at relapse. Experimental Design: To uncover mu
Autor:
Kerby Shedden, Nan Hu, Kamlai Saiya-Cork, Sami N. Malek, Sriram Balasubramanian, Nisar A. Amin
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(4)
Purpose: Ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, is approved for the treatment of relapsed chronic lymphocytic leukemia (CLL) and CLL with del17p. Mechanistically, ibrutinib interferes with B-cell receptor (BCR) signaling as well as mult
Autor:
Sami N. Malek, Sajid Shakhan, Jinghui Li, Peter Ouillette, Roxane Collins, Cheng Li, Kerby Shedden
Publikováno v:
Clinical Cancer Research. 17:6778-6790
Purpose: To further our understanding of the biology and prognostic significance of various chromosomal 13q14 deletions in chronic lymphocytic leukemia (CLL). Experimental Design: We analyzed data from SNP 6.0 arrays to define the anatomy of various
Autor:
Judith E. Karp, Harry P. Erba, Brian Parkin, Moshe Talpaz, Sajid Shakhan, Paula L. Bockenstedt, Cheng Li, Sami N. Malek, Ammar Al-Zoubi, Diane Roulston, Yang Liu, Kerby Shedden, Yin Wang, Lisa Kujawski, Yan Liu, Amanda Dressel, Whitney Wright, Anjali A. Purkayastha, Peter Ouillette
Publikováno v:
Clinical Cancer Research. 16:4135-4147
Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML). Experimental Design: We analyzed DNA from highly purified AML blasts and paired buccal cells from 95 patients for recu
Autor:
Cheong J. Lee, Chen Li, Lan Dai, HuyVuong Quoc, Diane M. Simeone, Kerby Shedden, Chenwei Li, David M. Lubman
Publikováno v:
Journal of Proteome Research. 9:3394-3402
Analyzing subpopulations of tumor cells in tissue is a challenging subject in proteomic studies. Pancreatic cancer stem cells (CSCs) are such a group of cells that only constitute 0.2-0.8% of the total tumor cells but have been found to be the origin
Autor:
Peter Ouillette, Li Ding, Ammar Al-Zoubi, Sami N. Malek, Kerby Shedden, Samuel Fossum, Brian Parkin, Paula L. Bockenstedt
Publikováno v:
Clinical Cancer Research. 16:835-847
Purpose: Genomic complexity is present in approximately 15% to 30% of all chronic lymphocytic leukemia (CLL) and has emerged as a strong independent predictor of rapid disease progression and short remission duration in CLL. We conducted this study t