Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Naomi Guppy"'
Autor:
Phil Bland, Harry Saville, Abigail Read, Patty Wai, Gareth Muirhead, Lucinda Curnow, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie John, Somaieh Hedayat, Holly Barker, James Wright, Lu Yu, Ioanna Mavrommati, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Samantha Barlow, Helen Kalirai, Sarah Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher Lord, Rachael Natrajan
Publikováno v:
Cancer Research. 83:P6-10
Background: Heterozygous hotspot mutations in the RNA splicing factor SF3B1, occur in 3% of unselected breast cancers and are associated with oestrogen receptor (ER+) breast cancer (BC) where they are enriched in metastatic disease and are associated
Autor:
Richard Newman, Beatrice A. Howard, Siu Man Tsang, Naomi Guppy, Naa-Anyima Boateng, Erik Oliemuller, Hyojin Kim
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
Little is known about the role of Sox11 in the regulation of mammary progenitor cells. Sox11 is expressed by mammary bud epithelial cells during embryonic mammary gland development and is not detected in mammary epithelial cells after birth. As Sox11
Autor:
Aaron S. Mansfield, Laurel Schunselaar, Naomi Guppy, Andrew M. Fry, Anita Singh, Sam M. Janes, Joanna Działo, Aimee Parsons, Paul Baas, Laura O'Regan, Neelam Kumar, Sara Busacca, Dean A. Fennell, Michael Sheaff, Apostolos Nakas, Annabel J. Sharkey, Alan G. Dawson
Publikováno v:
Molecular Cancer Therapeutics, 20(2), 379-388. AMER ASSOC CANCER RESEARCH
Mesothelioma is a universally lethal cancer lacking effective therapy. The spindle poison vinorelbine exhibits clinical activity in the relapsed setting, and in preclinical models requires BRCA1 to initiate apoptosis. However, the mechanisms underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d700c6dfa63021d5d9560151417e146
https://hdl.handle.net/1887/3276392
https://hdl.handle.net/1887/3276392
Autor:
Jyoti S. Choudhary, Lu Yu, Snezana Susnjar, Andrew Tutt, Patty Wai, Frances Daley, Natasa Medic Milijic, Rachael Natrajan, Daniela Kolarevic, Sophie Postel-Vinay, Barrie Peck, Ioanna Mavrommati, Hannah Cottom, Gareth Muirhead, Gillian Farnie, Gerard P. Quinn, Eleanor Knight, Rebecca Marlow, Richard Buus, Patrycja Gazinska, Simon S. McDade, Sunil Pancholi, Lesley-Ann Martin, Philip A. Bland, Naomi Guppy, Maggie C.U. Cheang, Sarah Maguire, Fredrik Wallberg, Amy Gibson, Paul H. Huang, Daniela Novo, Keith Brennan, Divya Kriplani, Farzana Noor, Giulia Falgari, Erle Holgersen, Eamonn Morrison, Syed Haider, Holly E. Barker, Kalnisha Naidoo, Ioannis Roxanis, Lukas Krasny
Publikováno v:
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e592d50d40abfd2812812de9e1d658c
https://doi.org/10.1158/0008-5472.CAN-20-1822
https://doi.org/10.1158/0008-5472.CAN-20-1822
Autor:
Saira Khalique, Sarah Nash, Katherine Vroobel, Dipa Begum, Nik Matthews, Naomi Guppy, Hannah Cottom, Harriet Kemp, Kerry Fenwick, Rachael Natrajan, Susana Banerjee, Richard Buus, Ayoma D. Attygale, Julian Wampfler, Ioannis Roxanis, Alan Melcher, Mike Hubank, Pradeep Ramagiri, Thomas Jones, Syed Haider, David Mansfield, Katharina von Loga, Christopher J. Lord
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3854, p 3854 (2021)
Volume 13
Issue 15
Cancers, Vol 13, Iss 3854, p 3854 (2021)
Volume 13
Issue 15
Simple Summary Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer that has a poor response to chemotherapy. Here, we assessed the immunological features of a series of 33 OCCCs and identified an immune-related gene exp
Autor:
Victoria Roulstone, Patrycja Gazinska, Alan Melcher, Andrew J. Hayes, Gareth J. Inman, Gianmaria Liccardi, Kevin J. Harrington, Naomi Guppy, Emma Davies, Pascal Meier, Jasbani H.S. Dayal, Joan Kyula-Currie, Kunzah Jamal, Henry G. Smith, Tencho Tenev, Ioannis Roxanis
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response. Moreover, resis
Autor:
Cara Brodie, Danya Cheeseman, Dominique-Laurent Couturier, Sanjeev Kumar, Jason S. Carroll, Naomi Guppy, Kosuke Yusa, Evangelia K. Papachristou, Sankari Nagarajan, Jose-Enrique Gonzalez Prada, Carlos Caldas, Alejandra Bruna, Joseph Sutton, Shanade Dunn, Emily Archer Goode, Silvia-Elena Glont, Rachael Natrajan, Shalini V. Rao, Igor Chernukhin, Rasmus Siersbæk, Kamal Kishore, Chandra Sekhar Reddy Chilamakuri, Alasdair Russell
Publikováno v:
Nature Genetics
Nature genetics
Nagarajan, S, Rao, S V, Sutton, J, Cheeseman, D, Dunn, S, Papachristou, E K, Prada, J G, Couturier, D, Kumar, S, Kishore, K, Chilamakuri, C S R, Glont, S, Archer Goode, E, Brodie, C, Guppy, N, Natrajan, R, Bruna, A, Caldas, C, Russell, A, Siersbæk, R, Yusa, K, Chernukhin, I & Carroll, J S 2020, ' ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response ', Nature Genetics, vol. 52, no. 2, pp. 187-197 . https://doi.org/10.1038/s41588-019-0541-5
Nature genetics
Nagarajan, S, Rao, S V, Sutton, J, Cheeseman, D, Dunn, S, Papachristou, E K, Prada, J G, Couturier, D, Kumar, S, Kishore, K, Chilamakuri, C S R, Glont, S, Archer Goode, E, Brodie, C, Guppy, N, Natrajan, R, Bruna, A, Caldas, C, Russell, A, Siersbæk, R, Yusa, K, Chernukhin, I & Carroll, J S 2020, ' ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response ', Nature Genetics, vol. 52, no. 2, pp. 187-197 . https://doi.org/10.1038/s41588-019-0541-5
Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endocrine drug resistance, we discovered ARID1A and other SWI/SNF complex components as the factors most critically required for response to tw
Autor:
Naomi Guppy, Sabari Vallath, Robert B. Good, Elizabeth K. Sage, L. Wessels, Sam M. Janes, Constantine Alifrangis, Yuki Ishii, Dean A. Fennell, Stacey Price, Annabel J. Sharkey, Howard Lightfoot, David A. Waller, Krishna K. Kolluri, S von Karstedt, David A. Tice, Syd Barthorpe, ZhengQiang Yuan, Henning Walczak, Antonella Montinaro, Magali Michaut, Alan M. Holmes, Apostolos Nakas, Sara Busacca, Steven P. Williams, Neelam Kumar, Ultan McDermott, Doraid Alrifai, Francesco Iorio, J. Le Quesne, Mathew J. Garnett
Publikováno v:
BTS/BALR/BLF Early Career Investigators awards symposium.
Introduction Malignant mesothelioma (MM) has no biomarker driven therapies in routine clinical use. We used a drug screen of molecularly characterised MM lines to identify novel genomic biomarker driven therapy. This led to the discovery of a subset
Autor:
Neelam Kumar, Elaine Borg, Elizabeth K. Sage, Krishna K. Kolluri, Naomi Guppy, Doraid Alrifai, Matthew Nankivell, Sam M. Janes, Andrew G. Nicholson, Yuki Ishii, Mary Falzon
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 127
Introduction BRCA1 associated protein-1 (BAP1) is a key tumor driver in mesothelioma and a potential biomarker predicting response to several targeted therapies in clinical testing. Whether it also modulates response to cytotoxic chemotherapy is unde
Autor:
Dominique-Laurent Couturier, Jose-Enrique Gonzalez Prada, Rachael Natrajan, Carlos Caldas, Rasmus Siersbæk, Kamal Kishore, Shalini V. Rao, Igor Chernukhin, Cara Brodie, Jason S. Carroll, Silvia-Elena Glont, Alejandra Bruna, Chandra Sekhar Reddy Chilamakuri, Emily Archer Goode, Evangelia K. Papachristou, Alasdair Russell, Sankari Nagarajan, Danya Cheeseman, Naomi Guppy, Sanjeev Kumar, Kosuke Yusa, Joseph Sutton, Shanade Dunn
Publikováno v:
Nature Genetics. 52:354-354