Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Momoe Itsumi"'
Autor:
Akira Yamauchi, Keisuke Kitakaze, Shuichiro Okamoto, Kei Miyano, Hitomi Kato, Mizuho Kajikawa, Momoe Itsumi, Chikage Kawai, Futoshi Kuribayashi
Publikováno v:
Biochemical and Biophysical Research Communications. 587:78-84
An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble
Autor:
Momoe Itsumi, Masaki Shiota, Takeshi Uchiumi, Junichi Inokuchi, Miho Ushijima, Masatoshi Eto, Ario Takeuchi, Shunichi Kajioka, Yohei Sekino, Eiji Kashiwagi
Publikováno v:
The Prostate. 80:885-894
Background Eradication of persistent androgen receptor (AR) activity in castration-resistant prostate cancer may be a promising strategy to overcome castration resistance. We aimed to identify novel compounds that inhibit AR activity and could be pot
Autor:
Momoe Itsumi, Shunichi Kajioka, Hirona Ichikawa, Ken Lee, Makoto Tomita, Shoji Yamaoka, Tomoko Maki
Publikováno v:
Biochemical and Biophysical Research Communications. 495:64-70
Exchange protein directly activated by cAMP (EPAC) is a mediator of a cAMP signaling pathway that is independent of protein kinase A. EPAC has two isoforms (EPAC1 and EPAC2) and is a cAMP-dependent guanine nucleotide exchange factor for the small GTP
Autor:
Momoe Itsumi, Takeshi Uchiumi, Ario Takeuchi, Hidetoshi Kuruma, Akira Yokomizo, Kenjiro Imada, Katsunori Tatsugami, Yoshinao Oda, Junichi Inokuchi, Masaki Shiota, Seiji Naito
Publikováno v:
Endocrine-Related Cancer. 22:889-900
Although invasive and metastatic progression via the epithelial-mesenchymal transition (EMT) and acquisition of resistance to castration are both critical steps in prostate cancer, the molecular mechanism of this interaction remains unclear. In this
Autor:
Kenjiro Imada, Eiji Kashiwagi, Momoe Itsumi, Seiji Naito, Katsunori Tatsugami, Junichi Inokuchi, Takeshi Uchiumi, Akira Yokomizo, Masaki Shiota, Ario Takeuchi
Publikováno v:
The Prostate. 74:959-969
BACKGROUND Previously, we have shown that Y-box binding protein-1 (YB-1) regulates androgen receptor (AR) expression and contributes to castration resistance. However, the mechanism of YB-1 activation remains unknown. In this study, we aimed to eluci
Autor:
Takashi Dejima, Ario Takeuchi, Shingo Tanaka, Katsunori Tatsugami, Seiji Naito, Momoe Itsumi, Masaki Shiota, Masatoshi Eto, Akira Yokomizo, Kentaro Kuroiwa
Publikováno v:
Cancer Immunology, Immunotherapy. 62:517-527
Renal cell carcinoma (RCC) accounts for 80-95 % of kidney tumors, and approximately 30 % of RCC patients have metastatic disease at diagnosis. Conventional chemotherapy is not effective in patients with metastatic RCC (MRCC); therefore, immunotherapy
Autor:
Tatsuro Abe, Masaki Shiota, Momoe Itsumi, Masaaki Sugimoto, Kenichi Kohashi, Yoshinao Oda, Kentaro Kuroiwa, Seiji Naito, Yuichi Yamada
Publikováno v:
Pathobiology : journal of immunopathology, molecular and cellular biology. 83(6)
Aims: The aims of this study were to investigate the association of renal cell carcinoma (RCC) displaying rhabdoid features and morphologically mesenchymal characteristics with epithelial to mesenchymal transition (EMT), and to clarify the expression
Autor:
Momoe Itsumi, Masaki Shiota, Yasuhiro Tada, Seiji Naito, Daisuke Masubuchi, YooHyun Song, Takeshi Uchiumi, Akira Yokomizo, Eiji Kashiwagi
Publikováno v:
BJU International. 108:E142-E149
What’s known on the subject? and What does the study add? So far, transcription factor Twist1 has been reported to regulate Y-box binding protein-1 (YB-1) expression and play important roles in tumour growth, invasion and drug resistance. This stud
Autor:
Momoe Itsumi, Ario Takeuchi, Katsunori Tatsugami, Junichi Inokuchi, Eiji Kashiwagi, Seiji Naito, Takeshi Uchiumi, YooHyun Song, Akira Yokomizo, Masaki Shiota
Publikováno v:
Journal of molecular endocrinology. 50(3)
Androgen receptor (AR) signaling is critical for the tumorigenesis and development of prostate cancer, as well as the progression to castration-resistant prostate cancer. We previously showed that the heterochromatin protein 1 (HP1) β isoform plays
Autor:
Eiji Kashiwagi, Masaki Shiota, Momoe Itsumi, Seiji Naito, Takeshi Uchiumi, Akira Yokomizo, Junichi Inokuchi
Publikováno v:
Endocrine-related cancer. 20(3)
Although numerous epidemiological studies show aspirin to reduce risk of prostate cancer, the mechanism of this effect is unclear. Here, we first confirmed that aspirin downregulated androgen receptor (AR) and prostate-specific antigen in prostate ca