Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marc Valentine"'
Autor:
Jeffrey E. Rubnitz, Masayuki Umeda, Todd A. Alonzo, Jenny L. Smith, Sherif Abdelhamed, Jamie L. Maciaszek, Michael Rusch, Ilaria Iacobucci, M. Madan Babu, Jinghui Zhang, Pandurang Kolekar, Evadnie Rampersaud, Jing Ma, Guangchun Song, Gang Wu, Jeffery M. Klco, James R. Downing, Hiroto Inaba, Xiaotu Ma, Melvin Edward Thomas, Scott G. Foy, Evan Parganas, Yanling Liu, Yi-Cheng Wang, Marc Valentine, Bensheng Ju, Stanley Pounds, Juan Martin Barajas, Tamara Westover, Quang Tran, Huiyun Wu, Jonathan Miller, Amanda R. Leonti, Benjamin J. Huang, Michael P. Walsh, Virginia Valentine, Rhonda E. Ries, John Easton, Jason Myers, Andrew B. Kleist, Kohei Hagiwara, Delaram Rahbarinia, Xiao-Long Chen, Ryan Hiltenbrand, Soheil Meshinchi, Liqing Tian, Charles G. Mullighan, Yen-Chun Liu
Publikováno v:
Blood. 138:LBA-4
Children with acute myeloid leukemia (AML) have a dismal prognosis due to a high relapse rate; however, the molecular basis leading to relapsed pediatric AML has not yet been fully characterized. To define the spectrum of alterations common at relaps
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate
Autor:
Marc Valentine, Patrick A. Zweidler-McKay, Sa A. Wang, Kathryn G. Roberts, Nitin Jain, Charles G. Mullighan, Marina Konopleva, Xinyan Lu, Maitrayee Goswami, Jeffrey L. Jorgensen, Sergej Konoplev, Carlos E. Bueso-Ramos, Juan Ouyang
Publikováno v:
American Journal of Clinical Pathology. 147:357-363
Objectives Cytokine receptor-like factor 2 ( CRLF2 ) rearrangement is found in approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and around 50% of CRLF2 + cases harbor JAK mutations. We analyzed CRLF2 expression and
Autor:
Diane Flasch, Jinghui Zhang, Yanling Liu, Michael Rusch, Suzanne J. Baker, Robin Paul, Jaimin Patel, Chunliang Li, Ying Shao, Edgar Sioson, Xiaotu Ma, Yu Liu, Liqing Tian, John Easton, Marc Valentine, Samuel W. Brady, Scott Newman, Jian Wang, Xin Zhou, Michael N. Edmonson
Publikováno v:
Cancer Cell
GenomePaint (https://genomepaint.stjude.cloud/) is an interactive visualization platform for whole-genome, whole-exome, transcriptome, and epigenomic data of tumor samples. Its design captures the inter-relatedness between DNA variations and RNA expr
Autor:
Seungjae Lee, Elizabeth Stewart, James R. Downing, Armita Bahrami, Heather L. Mulder, Marc Valentine, Jianrong Wu, Rani E. George, Donald Yergeau, Michael D. Hogarty, Maged Zeineldin, Elaine R. Mardis, Xin Zhou, Sara M. Federico, Beisi Xu, Anang A. Shelat, Richard K. Wilson, Yanling Liu, Jinghui Zhang, Jongrye Jeon, Arlene Naranjo, Shondra M. Pruett-Miller, John Easton, Michael R. Clay, Collin Van Ryn, Lyra Griffiths, Xiang Chen, Yiping Fan, Marcin Kamiński, Alberto S. Pappo, Michael A. Dyer
SUMMARYAggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9c9691bc389d4e691e3cbd0c5b70af
https://doi.org/10.1101/379636
https://doi.org/10.1101/379636
Autor:
Vaibhav Sahai, Jerold E. Rehg, Lesa Begley, David Escobar, Marc Valentine, Peter J. McKinnon, Jianming Ye, Ming Yi Chiang, Beatriz Sosa-Pineda, Leena Paul, Yiannis Drosos, Virginia Valentine, Kathryn Roys
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility, and ATM somatic mutations have been identified in resected human pancreatic tumors. Here we
Autor:
Stephen P. Hunger, Elizabeth A. Raetz, Julie M. Gastier-Foster, Cheryl L. Willman, Mignon L. Loh, Yu Liu, Brent L. Wood, William L. Carroll, Heather Jenkins, Andrew J. Carroll, Eileen Stonerock, Jonathan V. Nguyen, Michael J. Burke, Yunfeng Dai, Zhaohui Gu, Karen R. Rabin, John Easton, I-Ming Chen, Thai Hoa Tran, Anne L. Angiolillo, Amy Smith, Kathryn G. Roberts, Meenakshi Devidas, Debbie Payne-Turner, Michael J. Borowitz, Marc Valentine, Charles G. Mullighan, Patrick A. Zweidler-McKay, Yongjin Li, Ying Shao, Nyla A. Heerema, Wanda L. Salzer, Jinghui Zhang, Richard C. Harvey, Shalini C. Reshmi
Publikováno v:
Blood. 129(25)
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype characterized by genomic alterations that activate cytokine receptor and kinase signaling. We examined the frequency and spectrum of targetable genetic l
Autor:
Christopher Calabrese, Jerold E. Rehg, Marc Valentine, Tamar Uziel, Martine F. Roussel, Charles J. Sherr, Frederique Zindy, Richard J. Gilbertson, Olivier Ayrault
Publikováno v:
Cancer Research. 67:2676-2684
Mice lacking p53 and one or two alleles of the cyclin D–dependent kinase inhibitor p18Ink4c are prone to medulloblastoma development. The tumor frequency is increased by exposing postnatal animals to ionizing radiation at a time when their cerebell
Autor:
Yu Liu, Cheryl L. Willman, Meenakshi Devidas, I-Ming Chen, Stephen P. Hunger, Marc Valentine, Brent L. Wood, Shalini C. Reshmi, Mignon L. Loh, Kathryn G. Roberts, Nyla A. Heerema, Wanda L. Salzer, Charles G. Mullighan, Jinghui Zhang, Richard C. Harvey, Andrew J. Carroll, Karen R. Rabin, Michael M. Burke, Anne L. Angiolillo, William L. Carroll, Debbie Payne-Turner, John Easton, Elizabeth A. Raetz, Julie M. Gastier-Foster, Yongjin Li, Ying Shao, Michael J. Borowitz, Amy Smith, Patrick A. Zweidler-McKay
Publikováno v:
Cancer Research. 75:4729-4729
Introduction: While cure rates exceed 80%, many children with B-ALL still relapse. Many of these patients (pts) display a Ph-like gene expression profile (GEP), but lack canonical BCR-ABL1 fusion. We have identified alternate kinase fusions in Ph-lik
Autor:
Susan T. Rowe, Edwin C. Douglass, David M. Parham, Roger Berkow, W. Paul Bowman, Marc Valentine, Harold M. Maurer
Publikováno v:
Genes, chromosomescancer. 3(6)
In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the