Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Lionel Feigenbaum"'
Publikováno v:
Cell Immunol
Mice that express a single transgenic T cell receptor have a low incidence of T cell lymphoma development. We investigated whether this tumor development is restricted by surveillance mechanisms that are exerted by IL-15-dependent cells. Lymphoma inc
Autor:
David L. Huso, Saraswati Sukumar, Nguyen Nguyen, Lionel Feigenbaum, Pedram Argani, Manfred Gessler, Göran Landberg, Soonweng Cho, Scott L. Kominsky, Preethi Korangath, Wei Wen Teo, Adam Diehl, Liangfeng Han, Alan Rein
Publikováno v:
Cancer Research. 74:6509-6518
Acquired resistance to TGFβ is a key step in the early stages of tumorigenesis. Mutations in TGFβ signaling components are rare, and little is known about the development of resistance in breast cancer. On the other hand, an activated Notch pathway
Autor:
Alfred Singer, Terry I. Guinter, Motoko Y. Kimura, Lionel Feigenbaum, Anthony J. Adams, Anastasia N. Tikhonova, François Van Laethem, Xuguang Tai, Susan O. Sharrow, Cecile Le Saout, Leonid A. Pobezinsky, Günter Bernhardt
Publikováno v:
Cell. 154:1326-1341
Summary Thymic selection requires signaling by the protein tyrosine kinase Lck to generate T cells expressing αβ T cell antigen receptors (TCR). For reasons not understood, the thymus selects only αβTCR that are restricted by major histocompatibi
Autor:
Dinah S. Singer, Jie Mu, Terry I. Guinter, Motoko Y. Kimura, Ruth Etzensperger, Batu Erman, Lionel Feigenbaum, Gil Katz, Tom M. McCaughtry, Xuguang Tai, Alfred Singer, Amala Alag
Publikováno v:
Immunity. 38:1116-1128
SummaryImmune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of Treg cell development and function. We report here that Foxp3 was lethal to develop
Autor:
Ehydel Castro, Yumei Xiong, Jinfang Zhu, Lionel Feigenbaum, Ryoji Yagi, Renaud Lesourne, Paul E. Love, Rémy Bosselut
Publikováno v:
European Journal of Immunology. 43:918-928
CD4(+) helper T cells are essential for immune responses and differentiate in the thymus from CD4(+) CD8(+) "double-positive" (DP) thymocytes. The transcription factor Runx3 inhibits CD4(+) T-cell differentiation by repressing Cd4 gene expression; ac
Autor:
Andrea Lenzi, A. Isidori, Ma Venneri, Federica Barbagallo, Fabio Naro, Roberto Gimmelli, Manuela Pellegrini, S. Di Siena, Susanna Dolci, Stefania Lucia Nori, Teresa Mancuso, Eleonora Cianflone, Federica Campolo, Pellegrino Rossi, Daniele Torella, Daniele Gianfrilli, Elisa Giannetta, Lionel Feigenbaum
Publikováno v:
Cell Death & Disease
Cell death and disease 7 (2016). doi:10.1038/cddis.2016.205
info:cnr-pdr/source/autori:Di Siena S.; Gimmelli R.; Nori S.L.; Barbagallo F.; Campolo F.; Dolci S.; Rossi P.; Venneri M.A.; Giannetta E.; Gianfrilli D.; Feigenbaum L.; Lenzi A.; Naro F.; Cianflone E.; Mancuso T.; Torella D.; Isidori A.M.; Pellegrini M./titolo:Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury/doi:10.1038%2Fcddis.2016.205/rivista:Cell death and disease/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Europe PubMed Central
Cell death and disease 7 (2016). doi:10.1038/cddis.2016.205
info:cnr-pdr/source/autori:Di Siena S.; Gimmelli R.; Nori S.L.; Barbagallo F.; Campolo F.; Dolci S.; Rossi P.; Venneri M.A.; Giannetta E.; Gianfrilli D.; Feigenbaum L.; Lenzi A.; Naro F.; Cianflone E.; Mancuso T.; Torella D.; Isidori A.M.; Pellegrini M./titolo:Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury/doi:10.1038%2Fcddis.2016.205/rivista:Cell death and disease/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
Europe PubMed Central
The role of endogenous c-Kit receptor activation on cardiac cell homeostasis and repair remains largely unexplored. Transgenic mice carrying an activating point mutation (TgD814Y) in the kinase domain of the c-Kit gene were generated. c-KitTgD814Y re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ae5fb9882292cd8fc3e913d1909a35
http://hdl.handle.net/11573/880948
http://hdl.handle.net/11573/880948
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts Sporadic mouse tumor models are valuable tools to understand disease development and treatment efficacies. Here we show that a transgenic T cell receptor expression predisposes mice to leukemia/lymphoma development. Leukemia/lymphom
Autor:
Ogyi Park, Shi Yin, Seong Ho Yoo, Lionel Feigenbaum, Steven Dooley, Hai Li, Hua Wang, Fu-Sheng Wang, Howard A. Young, Bin Gao, Honglei Weng, Sung Hwan Ki
Publikováno v:
Hepatology. 54:252-261
Interleukin-22 (IL-22), which acts as either a proinflammatory or anti-inflammatory cytokine in various disease models, is markedly up-regulated in chronic liver diseases, including hepatitis B and C. In this report, we demonstrate a strong correlati
Autor:
Julie A. Gaasch, Emily Hua, Lionel Feigenbaum, Patricia S. Steeg, Quentin R. Smith, Natasha M. Flores, Eleazar Vega-Valle, Kunal S Taskar, Kaci A. Bohn, Diane Palmieri, Jeanne M. Herring, Helen R. Thorsheim, Seth M. Steinberg, Paul R. Lockman, Paul S. Meltzer, David J. Liewehr, Elizabeth Hargrave, Vinay Rudraraju, Matthew Johnson, John F. Reilly, Kevin Camphausen, Victoria M. Richon, Robert L. Walker, Yongzhen Qian, Sean Davis, Rajendar K. Mittapalli, Fancy Thomas, Julie L. Bronder
Publikováno v:
Clin Cancer Res
Purpose: As chemotherapy and molecular therapy improve the systemic survival of breast cancer patients, the incidence of brain metastases increases. Few therapeutic strategies exist for the treatment of brain metastases because the blood-brain barrie
Publikováno v:
Journal of Immunotherapy. 32:129-139
Many antigens recognized by tumor-reactive cytotoxic CD8+ T cells are self-antigens. Tyrosinase-related protein 2 (TRP-2) is a melanogenic enzyme expressed by both melanocytes and melanomas that is reported to be a candidate melanoma rejection antige