Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Krzysztof Mrózek"'
Autor:
Krzysztof Mrózek, Jessica Kohlschmidt, James S. Blachly, Deedra Nicolet, Andrew J. Carroll, Kellie J. Archer, Alice S. Mims, Karilyn T. Larkin, Shelley Orwick, Christopher C. Oakes, Jonathan E. Kolitz, Bayard L. Powell, William G. Blum, Guido Marcucci, Maria R. Baer, Geoffrey L. Uy, Wendy Stock, John C. Byrd, Ann-Kathrin Eisfeld
Publikováno v:
Leukemia. 37:788-798
Recently, the European LeukemiaNet (ELN) revised its genetic-risk classification of acute myeloid leukemia (AML). We categorized 1637 adults with AML treated with cytarabine/anthracycline regimens according to the 2022 and 2017 ELN classifications. C
Autor:
Amy S. Ruppert, Larry Beaver, Bonnie K. Harrington, Janek S. Walker, Brandi R. Walker, Katie Williams, James Cronin, Zachary A. Hing, Alexander Pan, Jordan N. Skinner, Jennifer A. Woyach, Nyla A. Heerema, Steven Sher, Amy Lehman, Charles Thomas Gregory, Vincenzo Coppola, Rosa Lapalombella, Krzysztof Mrózek, Max Yano, Pearlly S. Yan, Hatice Gulcin Ozer, James S. Blachly, Jadwiga Labanowska, John C. Byrd, Casey Cempre
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the immunoglobulin heavy chain locus (IGH; 14q32) in chronic lymphocytic leukemia (CLL) are infrequent but
Autor:
Sophia E. Maharry, Clara D. Bloomfield, Marius Bill, Sandya Liyanarachchi, Christopher C. Oakes, Chi Song, Christopher J. Walker, Albert de la Chapelle, Geoffrey L. Uy, Brian Giacopelli, James S. Blachly, Bayard L. Powell, Eunice S. Wang, Shelley Orwick, Jonathan E. Kolitz, Richard Stone, Deedra Nicolet, Kellie J. Archer, Ann-Kathrin Eisfeld, John C. Byrd, Luke K Genutis, Jessica Kohlschmidt, Dimitrios Papaioannou, Krzysztof Mrózek, Andrew J. Carroll
Publikováno v:
Clin Cancer Res
Purpose:Uniparental disomy (UPD) is a way cancer cells duplicate a mutated gene, causing loss of heterozygosity (LOH). Patients with cytogenetically normal acute myeloid leukemia (CN-AML) do not have microscopically detectable chromosome abnormalitie
Autor:
Marius Bill, Bayard L. Powell, John C. Byrd, Brian Giacopelli, Jessica Kohlschmidt, Jonathan E. Kolitz, Dimitrios Papaioannou, Christopher C. Oakes, Ramiro Garzon, Krzysztof Mrózek, Richard Stone, Andrew J. Carroll, Ann-Kathrin Eisfeld, Deedra Nicolet, Clara D. Bloomfield
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021)
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021)
Recently, a novel knowledge bank (KB) approach to predict outcomes of individual patients with acute myeloid leukemia (AML) was developed using unbiased machine learning. To validate its prognostic value, we analyzed 1612 adults with de novo AML trea
Autor:
Clara D. Bloomfield, Bayard L. Powell, Andrew J. Carroll, Shelley Orwick, Ann-Kathrin Eisfeld, Jessica Kohlschmidt, Bhavana Bhatnagar, Dimitrios Papaioannou, Richard Stone, Deedra Nicolet, Krzysztof Mrózek, John C. Byrd, Jonathan E. Kolitz, Christopher J. Walker, James S. Blachly
Publikováno v:
Leukemia. 34:358-368
Sole trisomies of chromosomes 4, 8, 11, 13 and 21 account for 89–95% of all sole trisomies in adult AML patients. We analyzed clinical and molecular characteristics of 138 de novo AML patients with sole +4, +8, +11, +13 or +21, and compared them wi
Autor:
Jessica Kohlschmidt, Dimitrios Papaioannou, Clara D. Bloomfield, Paolo Fadda, Deedra Nicolet, Richard Stone, Andrew J. Carroll, John C. Byrd, Eunice S. Wang, Hatice Gulcin Ozer, Stefano Volinia, Jonathan E. Kolitz, Ramiro Garzon, Krzysztof Mrózek
Publikováno v:
Molecular Cancer Therapeutics. 18:1451-1459
We have previously shown that expression levels of 48 long noncoding RNAs (lncRNA) can generate a prognostic lncRNA score that independently associates with outcome of older patients with cytogenetically normal acute myeloid leukemia (CN-AML). Howeve
Autor:
Adrienne M. Dorrance, Aparna Pathmanathan, Jessica Kohlschmidt, Xiaoli Zhang, Marius Bill, Allison LaRocco, Zachary Brannan, Dimitrios Papaioannou, Clara D. Bloomfield, Krzysztof Mrózek, Stefano Volinia, Ramiro Garzon, Christopher J. Walker, Felice Pepe, Allison E. Walker, Malith Karunasiri
Publikováno v:
Leukemia. 33:2169-2182
In acute myeloid leukemia (AML), novel therapies are needed to target not only the rapidly dividing AML blasts but also the distinct population of leukemia stem cells (LSCs), which have abnormal self-renewal capacity and increased chemotherapy resist
Autor:
Jonathan E. Kolitz, William Blum, Christopher J. Walker, Ann-Kathrin Eisfeld, Jessica Kohlschmidt, James S. Blachly, Dimitrios Papaioannou, Deedra Nicolet, Geoffrey L. Uy, Eunice S. Wang, Marius Bill, Richard Stone, Krzysztof Mrózek, Bayard L. Powell, Clara D. Bloomfield, Andrew J. Carroll, John C. Byrd
Publikováno v:
Leukemia
Complex karyotype (CK) with ≥ 3 abnormalities is detected in 10–12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q,
Autor:
Brian Giacopelli, Markus Scholz, Pamela Brock, Sebastian Schwind, Andrew J. Carroll, Marius Bill, Christopher C. Oakes, John C. Byrd, Dietger Niederwieser, Christopher J. Walker, Richard Stone, Krzysztof Mrózek, Eunice S. Wang, Ann-Kathrin Eisfeld, Jonathan E. Kolitz, Clara D. Bloomfield, Bayard L. Powell, Luke K Genutis, Sandya Liyanarachchi, Albert de la Chapelle, Jessica Kohlschmidt, Deedra Nicolet
Publikováno v:
Leukemia. 33:771-775
Autor:
James S. Blachly, Ann-Kathrin Eisfeld, Richard Stone, Christopher J. Walker, Krzysztof Mrózek, Albert de la Chapelle, Bayard E. Powell, Andrew J. Carroll, Alice S. Mims, Deedra Nicolet, Jessica Kohlschmidt, Jonathan E. Kolitz, Dimitrios Papaioannou, Clara D. Bloomfield, John C. Byrd
Publikováno v:
Leukemia
The European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) have become an important tool to assess patients’ prognosis and guide treatment. We tested the prognostic impact of the 2017 ELN classificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899263e881c301e0751b5213e0cae6d1
https://europepmc.org/articles/PMC7882079/
https://europepmc.org/articles/PMC7882079/