Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kristina Xega"'
Autor:
Keli Song, James Minissale, Richard A. Klinghoffer, James Garnsey, Katherine Galvin, Kristina Xega, Sai M Pulukuri, James M. Gavin, Xiaofeng Yang, Pooja Shah, Gary Shapiro, Cong Li, Vaishali Shinde, Eric S. Lightcap, Dennis Huszar, Zhen Lu, Stephen Grossman, Erik Koenig, Pengfei Yu, Steve Langston, Hisashi Imaichi, Serge Y. Fuchs, Mithun Khattar, Beryl A. Hatton, Yu Fu, Hongru Zhang, Dylan England, Michael Milhollen, Jessica Riceberg, Xingyue He
Publikováno v:
Sci Transl Med
SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK-981, a selective small molecule inhibitor of SUMOylation, pharmacologi
Autor:
Akito Nakamura, Keli Song, Stephen Grossman, Kristina Xega, Yuhong Zhang, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background TAK-981 is a first-in-class small molecule inhibitor of the SUMO activating enzyme in Phase 1 clinical trials. SUMOylation has previously been implicated in the regulation of innate immune responses and expression of Type I interferons,1 a
Autor:
Murat Karabacak, Leah J. Damon, Andrew S. Liss, Jackson P. Fatherree, Richard Y. Ebright, Rushil Desai, Robert Morris, Daniel A. Haber, Mauro Di Pilato, Francesca Bersani, Jose Malagon-Lopez, Anupriya S. Kulkarni, Eric Tai, Nicole Vincent Jordan, Julia Philipp, Melissa Choz, A. W. K. Liu, Vikram Deshpande, Kristina Xega, Miguel Rivera, Joseph W. Franses, Johannes Kreuzer, Cyril H. Benes, Myriam Boukhali, Martin J. Aryee, Kevin D. Vo, Oliver Schilling, Francesco Marangoni, Matteo Ligorio, Adam Langenbucher, Sandra Misale, Srinjoy Sil, Michael S. Lawrence, Kshitij S. Arora, Wilhelm Haas, Linda T. Nieman, Vishal Thapar, Mihir Rajurkar, Chittampalli Yashaswini, Carlos Fernandez-del-Castillo, Cristina R. Ferrone, Niyati Desai, Elad Horwitz, David T. Ting, Shyamala Maheswaran, Ulrich F. Wellner, Neelima K.C. Magnus, Azfar Neyaz
Publikováno v:
Cell
Cell, vol 178, iss 1
Cell, vol 178, iss 1
Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been well defined. Combining single-cell RNA and protein analytics in studying the role of stroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8f16847960fab080e82c78f98d5029
http://hdl.handle.net/2318/1794764
http://hdl.handle.net/2318/1794764
Autor:
Abraham R. Tzafriri, Bryan C. Fuchs, Vikram Deshpande, Laura Indolfi, Cristina R. Ferrone, Robert Langer, Elazer R. Edelman, Vishal Thapar, Aaron B. Baker, Francesca Bersani, Daniel A. Haber, Kristina Xega, Jeffrey W. Clark, David T. Ting, Matteo Ligorio, Nicola Aceto
Publikováno v:
Biomaterials
PMC
PMC
Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating and painful cancers. It is often highly resistant to therapy owing to inherent chemoresistance and the desmoplastic response that creates a barrier of fibrous tissue preventing tr
Autor:
Miguel Rivera, Cyril H. Benes, Melissa Choz, Matteo Ligorio, Carlos Fernandez-del Castillo, Julia Philipp, Vikram Deshpande, Shyamala Maheswaran, Linda T. Nieman, Mihir Rajurkar, Francesca Bersani, Eric Tai, Vishal Thapar, Jose Malagon-Lopez, Joseph W. Franses, Daniel A. Haber, Nicole Vincent Jordan, Mauro Di Pilato, Leah J. Damon, Martin J. Aryee, Kevin D. Vo, Kristina Xega, Anupriya S. Kulkarni, Chittampalli Yashaswini, Johannes Kreuzer, Myriam Boukhali, Srinjoy Sil, Robert Morris, Cristina R. Ferrone, Kshitij S. Arora, David T. Ting, Niyati Desai, Wilhelm Haas, Murat Karabacak, Jackson P. Fatherree, Richard Y. Ebright, Rushil Desai, Sandra Misale, Francesco Marangoni
Publikováno v:
SSRN Electronic Journal.
Single cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single cell phenotypes have not been well defined. Combining single cell RNA and protein analytics in pancreatic cancer (PDAC) mo
Autor:
Vikram Deshpande, Kshitij S. Arora, Olivia C. MacKenzie, Haley Ellis, Miguel Rivera, Daniel A. Haber, Huili Zhu, David T. Miyamoto, Mohammad Shahid, Sridhar Ramaswamy, Ben S. Wittner, Jordan C. Ciciliano, Francesca Bersani, Matteo Ligorio, Ajay Shah, David T. Ting, Ravi Kapur, Toshi Shioda, Shyamala Maheswaran, Kristina Xega, Cristina R. Ferrone, Brian W. Brannigan, Nabeel Bardeesy, Mehmet Toner, Nicole Vincent Jordan, Na Qu, Julie Trautwein, Nicola Aceto
Publikováno v:
Cell reports
Cell Reports, Vol 8, Iss 6, Pp 1905-1918 (2014)
Cell Rep
Cell Reports, Vol 8, Iss 6, Pp 1905-1918 (2014)
Cell Rep
SUMMARY Circulating tumor cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. To define their composition, we compared genome-wide expression profiles of CTCs with matched pri
Autor:
Kristina Xega, Xingyue He, Neeraja Idamakanti, Mithun Khattar, Stephen Grossman, Keli Song, Dennis Huszar
Publikováno v:
Cancer Research. 79:3252-3252
SUMOylation is a reversible post-translational modification that regulates protein function by covalent attachment of the small ubiquitin-like modifier (SUMO) protein to protein substrates. TAK-981 is a novel, selective small molecule inhibitor of th
Autor:
Kristina Xega, Michael Milhollen, Dennis Huszar, Erik Koenig, Eric S. Lightcap, Vaishali Shinde, Stephen Grossman, Keli Song, Sharon Friedlander, Omid Ghasemi, Allison Berger, Pooja Shah, Gary Shapiro, Agatha Zawadzka
Publikováno v:
Cancer Research. 79:3079-3079
TAK-981 is a small molecule inhibitor of the SUMOylation enzyme cascade which is currently in a Phase I clinical trial (NCT03648372). TAK-981 selectively inhibits the activity of the SUMO activating enzyme, forming a covalent adduct between TAK-981 a
Autor:
Johara Chouitar, Dennis Huszar, Allison Berger, Katherine Galvin, Vaishali Shinde, Aimy Tse, Keli Song, Omid Ghasemi, Agatha Zawadzka, Patrick J. LeRoy, Kristina Xega, Evan Luongo, Xingyue He, Michelle Ganno-Sherwood, Stephan Grossman, Cierra Casson
Publikováno v:
Cancer Research. 79:LB-319
Mouse syngeneic tumor models play a crucial role in the translationally oriented process of assessing the preclinical activity and mechanism of action of emerging novel immunotherapies and immunotherapy combinations. Recent advancements in fluorescen
Autor:
Brinda Alagesan, Daniel A. Haber, Malgorzata E. Smas, David P. Ryan, Suchismita Paul, Gianmarco Contino, Nabeel Bardeesy, Min Yu, Brian W. Brannigan, Sridhar Ramaswamy, Fatih Ozsolak, Patrice M. Milos, Ben S. Wittner, Jordan C. Ciciliano, Mehmet Toner, David T. Ting, Daniel Winokur, Kristina Xega, Matthew J. Ulman, Anna J. Gilman, Lecia V. Sequist, Shannon L. Stott, Shyamala Maheswaran
Publikováno v:
Nature
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. Although these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne disse