Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Kristian Unger"'
Autor:
Mattis Bertlich, Friedrich Ihler, Jennifer L. Spiegel, Kristian Unger, Stefan Küffer, Frank Haubner, Bernhard G. Weiss, Martin Canis, Julia Kitz, Julia Hess, Mahalia Zoe Anczykowski, Mark Jakob
Publikováno v:
Cancer Biomarkers. 33:331-347
BACKGROUND: MicroRNAs constitute promising biomarkers. OBJECTIVE: The aim was to investigate diagnostic and prognostic implications of miR-182-5p and miR-205-5p in p16-positive and p16-negative oropharyngeal squamous cell carcinomas (OPSCCs). METHODS
Autor:
Sebastian Burkart, Christopher Weusthof, Karam Khorani, Sonja Steen, Fabian Stögbauer, Kristian Unger, Julia Hess, Horst Zitzelsberger, Claus Belka, Ina Kurth, Jochen Hess
Publikováno v:
Cancers; Volume 15; Issue 6; Pages: 1655
Purpose: Identification of molecularly-defined cancer subgroups and targeting tumor-specific vulnerabilities have a strong potential to improve treatment response and patient outcomes but remain an unmet challenge of high clinical relevance, especial
Autor:
Mechthild Krause, Jürgen Debus, Henning Schäfer, Bouchra Tawk, Maja Guberina, Sebastian Adeberg, Ingeborg Tinhofer, Karim Zaoui, Martin Stuschke, Steffi Pigorsch, Volker Budach, Julia Hess, Kristian Unger, Thomas Kirchner, Claus Rödel, Esther Herpel, Stephanie E. Combs, Christian Schwager, Amir Abdollahi, Panagiotis Balermpas, Jochen Hess, Anca L. Grosu, Horst Zitzelsberger, Annett Linge, Ute Wirkner, Fabian Lohaus, Melanie Bewerunge-Hudler, Dktk-Rog, Wilko Weichert, P.A. Federspil, Claus Belka, Ute Ganswindt, Katrin Rein, Michael H. Baumann, Philipp Baumeister, Daniel Zips
Publikováno v:
Int. J. Cancer, DOI: 10.1002/ijc.33842 (2021)
Biomarkers with relevance for loco-regional therapy are needed in human papillomavirus negative aka HPV(-) head and neck squamous cell carcinoma (HNSCC). Based on the premise that DNA methylation pattern is highly conserved, we sought to develop a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8abc971113262eef2722448354359d5
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85118946409
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85118946409
Autor:
Peter Weber, Axel Künstner, Julia Hess, Kristian Unger, Sebastian Marschner, Christian Idel, Julika Ribbat-Idel, Philipp Baumeister, Olivier Gires, Christoph Walz, Sibylle Rietzler, Laura Valeanu, Timm Herkommer, Lisa Kreutzer, Olena Klymenko, Guido Drexler, Thomas Kirchner, Cornelius Maihöfer, Ute Ganswindt, Axel Walch, Michael Sterr, Heiko Lickert, Martin Canis, Dirk Rades, Sven Perner, Mauricio Berriel Diaz, Stefan Herzig, Kirsten Lauber, Barbara Wollenberg, Hauke Busch, Claus Belka, Horst Zitzelsberger
Publikováno v:
Clin. Cancer Res. 28, 1038-1052 (2022)
Purpose: The genetic relatedness between primary and recurrent head and neck squamous cell carcinomas (HNSCC) reflects the extent of heterogeneity and therapy-driven selection of tumor subpopulations. Yet, current treatment of recurrent HNSCC ignores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce40f7b980fadb86885c12783f8b2d34
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64025
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64025
Autor:
Henrik Schinke, Enxian Shi, Zhongyang Lin, Tanja Quadt, Gisela Kranz, Jiefu Zhou, Hongxia Wang, Julia Hess, Steffen Heuer, Claus Belka, Horst Zitzelsberger, Udo Schumacher, Sandra Genduso, Kristoffer Riecken, Yujing Gao, Zhengquan Wu, Christoph A. Reichel, Christoph Walz, Martin Canis, Kristian Unger, Philipp Baumeister, Min Pan, Olivier Gires
Publikováno v:
Mol. Cancer 21:178 (2022)
Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC). However, response to EGFR treatment is inconsistent and lacks markers for treatment predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ea6c944678f71d2e9ff705739ff11e
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66150
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66150
Autor:
Dinesh Kumar Tiwari, Ricarda Hannen, Kristian Unger, Sibylla Kohl, Julia Heß, Kirsten Lauber, Florentine S. B. Subtil, Ekkehard Dikomey, Rita Engenhart-Cabillic, Ulrike Schötz
Publikováno v:
Front. Oncol. 12:878675 (2022)
BackgroundTreatment of locally advanced HPV-negative head and neck squamous cell carcinoma (HNSCC) with photon radiation is the standard of care but shows only moderate success. Alterations in response toward DNA DSB repair, apoptosis, and senescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795182333778faf68c8533abc562e1ea
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64975
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64975
Autor:
Julia Hess, Kristian Unger, Cornelius Maihoefer, Lars Schüttrumpf, Peter Weber, Sebastian Marschner, Ludmila Wintergerst, Ulrike Pflugradt, Philipp Baumeister, Axel Walch, Christine Woischke, Thomas Kirchner, Martin Werner, Kristin Sörensen, Michael Baumann, Ingeborg Tinhofer, Stephanie E. Combs, Jürgen Debus, Henning Schäfer, Mechthild Krause, Annett Linge, Jens von der Grün, Martin Stuschke, Daniel Zips, Martin Canis, Kirsten Lauber, Ute Ganswindt, Michael Henke, Horst Zitzelsberger, Claus Belka
Publikováno v:
Cancers; Volume 14; Issue 15; Pages: 3745
Cancers 14:3745 (2022)
Cancers 14:3745 (2022)
CA extern Simple Summary Human papillomavirus (HPV)-driven head and neck squamous cell carcinomas (HNSCC), regarded as a distinct clinical entity, are characterized by a considerably favourable prognosis after radio(chemo)therapy and a not yet fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146c9f1e05889bb049b6818c13d0e7aa
https://www.ncbi.nlm.nih.gov/pubmed/35954409
https://www.ncbi.nlm.nih.gov/pubmed/35954409
Autor:
Elia Lombardo, Julia Hess, Christopher Kurz, Marco Riboldi, Sebastian Marschner, Philipp Baumeister, Kirsten Lauber, Ulrike Pflugradt, Axel Walch, Martin Canis, Frederick Klauschen, Horst Zitzelsberger, Claus Belka, Guillaume Landry, Kristian Unger
Publikováno v:
Eur. J. Cancer 176, 41-49 (2022)
OBJECTIVE: HPV-associated head and neck cancer is correlated with favorable prognosis; however, its underlying biology is not fully understood. We propose an explainable convolutional neural network (CNN) classifier, DeepClassPathway, that predicts H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abf7857f77cb6767be0b8f2d6568eff
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66360
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66360
Autor:
Ulrike Schoetz, Diana Klein, Julia Hess, Seyd Shnayien, Steffen Spoerl, Michael Orth, Samet Mutlu, Roman Hennel, Anja Sieber, Ute Ganswindt, Benedikt Luka, Andreas R. Thomsen, Kristian Unger, Verena Jendrossek, Horst Zitzelsberger, Nils Blüthgen, Claus Belka, Steffen Unkel, Bertram Klinger, Kirsten Lauber
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death Dis. 12:1162 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
Cell Death Dis. 12:1162 (2021)
Resistance against radio(chemo)therapy-induced cell death is a major determinant of oncological treatment failure and remains a perpetual clinical challenge. The underlying mechanisms are manifold and demand for comprehensive, cancer entity- and subt
Autor:
Kristian Unger, Anne L. Jellema, Nynke A. Hosper, Vivian M.L. Ogundipe, Thera P. Links, Peter W. Nagle, Julia Hess, John T. M. Plukker, Hette Faber, Mirjam Baanstra, Robert P. Coppes, Andries H. Groen
Publikováno v:
Stem Cell Rep. 16, 913-925 (2021)
Stem Cell Reports
Stem Cell Reports, 16(4), 913-925. CELL PRESS
Stem Cell Reports
Stem Cell Reports, 16(4), 913-925. CELL PRESS
Summary Total thyroidectomy as part of thyroid cancer treatment results in hypothyroidism requiring lifelong daily thyroid hormone replacement. Unbalanced hormone levels result in persistent complaints such as fatigue, constipation, and weight increa