Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey E. DeClue"'
Autor:
Hongzhen Li, Shaowei Li, Richard Braverman, Douglas R. Lowy, William C. Vass, Jeffrey E. DeClue
Publikováno v:
Molecular Carcinogenesis. 37:98-109
We investigated the effects of overexpression of the tuberous sclerosis-1 and -2 (TSC1/2) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previous
Autor:
Ralf Wienecke, Neil A. Swanson, Eckart Klemm, Sarolta Karparti, Jeffrey E. DeClue, Andrew Green
Publikováno v:
Journal of Cutaneous Pathology. 29:287-290
Background: Patients affected with tuberous sclerosis complex (TSC) are prone to the development of multiple benign tumors of the skin and other organs. Tuberin, the protein product of the tuberous-sclerosis-complex-2 tumor suppressor gene (TSC2) has
Autor:
Giovanna Benvenuto, Nancy Ratner, Bo Ling, William C. Vass, David Viskochil, Shaowei Li, Sue C. Heffelfinger, Jeffrey E. DeClue, Wen Rui
Publikováno v:
Journal of Clinical Investigation. 105:1233-1241
We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and in animal models of this disease. This is surprising, because Schwann cells normally lack E
Publikováno v:
Oncogene. 15:1611-1616
Several inherited predisposition to cancer syndromes are associated with the development of nervous system tumors. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder in which affected individuals are at risk for developing astrocytoma
Autor:
S. Felzmann, D R Lowy, Gangfeng Xu, M. R. Johnson, William C. Vass, R. White, Jeffrey E. DeClue
Publikováno v:
Molecular and Cellular Biology. 14:641-645
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inac
Publikováno v:
Proceedings of the National Academy of Sciences. 90:5539-5543
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively regulate GTP-Ras by accelerating its conversion to inactive GDP-Ras. In schwannoma cell lines f
Autor:
Jonathan A. Fletcher, Douglas R. Lowy, Nancy Ratner, Scott R. Diehl, William C. Vass, Jeffrey E. DeClue, Alex G. Papageorge
Publikováno v:
Cell. 69:265-273
Tumor cell lines derived from malignant schwannomas removed from patients with neurofibromatosis type 1 (NF1) have been examined for the level of expression of NF1 protein. All three NF1 lines examined expressed lower levels of NF1 protein than contr
Autor:
Shyra J. Miller, Tilat A. Rizvi, Gabrielle deCourten-Myers, Jianqiang Wu, Nancy Ratner, Benjamin C. Ling, Kelly R. Monk, Kristine S. Vogel, Jeffrey E. DeClue, Rania Shamekh
Publikováno v:
Cancer cell. 7(1)
Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications of neurofibromatosis type 1. The epidermal growth factor receptor is not expressed by normal Schwann cells, yet is overexpressed in subpopulations of Nf1 muta
Autor:
Shaowei Li, Giovanna Benvenuto, Richard Braverman, Jeremy Peter Cheadle, Ralf Wienecke, Jeffrey E. DeClue, William C. Vass, Samantha J. Brown, Julian R. Sampson, Dicky J. J. Halley
Publikováno v:
Oncogene, 19, 6306-6316. Nature Publishing Group
We report here that overexpression of the tuberous sclerosis-1 (TSC1) gene product hamartin results in the inhibition of growth, as well as changes in cell morphology. Growth inhibition was associated with an increase in the endogenous level of the p
Autor:
Cathryn Rankin, Jeffrey E. DeClue, George Thomas Budd, Scott M. Schuetze, Cheryl M. Coffin, Karen Albritton, Ernest C. Borden, R. L. Randall, Nancy Ratner
Publikováno v:
Journal of Clinical Oncology. 24:9518-9518
9518 Background: MPNSTs are rare soft tissue tumors (STS) that are relatively resistant to chemotherapy. 26% have epidermal growth factor receptor (EGFR) amplification. In preclinical studies, NF1/p53 murine MPNSTs in vitro are stimulated by EGF and