Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Amer H. Zureikat, Ibrahim Nassour, David L Bartlett, Annissa Desilva, Lance A. Liotta, Aatur D. Singhi, Virginia Espina, Alessandro Paniccia, Samer AlMasri, Nathan Bahary, Brian A. Boone, Herbert J. Zeh, Patricia Loughran, Michael T. Lotze, Mazen S. Zenati
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 20, Pp 7233-7241 (2021)
Cancer Medicine, Vol 10, Iss 20, Pp 7233-7241 (2021)
Introduction Preoperative autophagy inhibition with hydroxychloroquine (HCQ) in combination with gemcitabine in pancreatic adenocarcinoma (PDAC) has been shown to be safe and effective in inducing a serum biomarker response and increase resection rat
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 18:804-823
Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis, limited treatment success and dismal prognosis. Exocrine tumours account for 95% of pancreatic cancers and the most common pathological type is pancreatic duc
Autor:
Gilbert Zvikomborero Murimwa, Jennie Meier, Mithin Nehrubabu, Adam C. Yopp, Herbert J. Zeh, Patricio M. Polanco
Publikováno v:
Journal of Clinical Oncology. 41:787-787
787 Background: Social vulnerability is a federal metric used to assess a community’s resilience in facing external stressors from disease or disaster. The social vulnerability index (SVI) includes 15 social factors obtained at the census tract lev
Autor:
Runliu Wu, Daniel J. Klionsky, Daolin Tang, Xin Chen, Jingbo Li, Xinxin Song, Herbert J. Zeh, Yinghua Xu, Xiaoyan Wang, Rui Kang, Jiao Liu
Publikováno v:
Autophagy
Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependen
Autor:
Enyong Dai, Leng Han, Yangchun Xie, Jiao Liu, Rui Kang, Herbert J. Zeh, Daolin Tang, Lulu Bai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Ferroptosis is a more recently recognized form of cell death that relies on iron-mediated oxidative damage. Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an important ferroptosis suppressor, i
Publikováno v:
Autophagy
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter “autophagy”) is one of the lysosome-dependent degradation systems that
Autor:
Sam C. Wang, Matthew R. Porembka, Raghav Chandra, Scott I. Reznik, Herbert J. Zeh, Neeraja Balachandar
Publikováno v:
Cancer Gene Therapy. 28:390-399
Gastric cancer is an aggressive solid-tumor malignancy with poor prognosis. The epidemiologic face of gastric cancer is changing and further insight into its heterogenous immunohistopathologic nature is needed to develop personalized therapies for sp
Autor:
Nina N. Sanford, Todd A. Aguilera, Muhammad Shaalan Beg, Linda Farkas, Herbert J. Zeh, Aravind Sanjeevaiah, Michael R. Folkert, Syed A. Kazmi
Publikováno v:
American Journal of Clinical Oncology. 43:850-856
BACKGROUND When, whether, and in whom primary tumor resection (PTR) for patients with metastatic colorectal cancer (CRC) is indicated remains unknown. With advances in multiagent systemic chemotherapy, PTR may be undertaken less frequently. The aim o
Autor:
Ahmed M. Elamir, John D. Karalis, Nina Niu Sanford, Patricio M. Polanco, Michael R. Folkert, Matthew R. Porembka, Syed Ali Kazmi, Ravikanth Maddipati, Herbert J. Zeh, Robert D. Timmerman, Song Zhang, Matteo Ligorio, Muhammad Shaalan Beg, Todd A. Aguilera
Publikováno v:
International journal of radiation oncology, biology, physics. 114(4)
The oligometastatic state is observed in patients across many malignancies, with increased recognition regarding improved outcomes after local therapies. However, there is limited data specifically regarding pancreatic ductal adenocarcinoma. We hypot
Autor:
Guido Kroemer, Yangchun Xie, Leng Han, Herbert J. Zeh, Enyong Dai, Jiao Liu, Rui Kang, Daniel J. Klionsky, Jing Wang, Daolin Tang
Publikováno v:
Autophagy
KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we rep