Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hailey, M."'
Publikováno v:
Cancer Research. 83:270-270
Non-small cell lung adenocarcinomas with concurrent oncogenic KRAS and SKT11 loss-of-function mutations represent an aggressive subtype that is characterized, in part, by increased metastasis and enhanced dependence on glutamine metabolism. The purpo
Autor:
Jenna G Eaton, Tyler C Hogan, Nikoletta Sidiropoulos, Cai L McCann, Hailey M. Sarausky, Kenneth J. Hampel, Gopika Nandagopal, David J. Seward, Paula B. Deming, Meagan A Lebeau, Margaret P Cameron, Jordan Armstrong, Sean M. Lenahan, Liam Donnelly
Publikováno v:
Carcinogenesis
Serine/Threonine Kinase 11 (STK11) encodes an important tumor suppressor that is frequently mutated in lung adenocarcinoma. Clinical studies have shown that mutations in STK11 resulting in loss of function correlate with resistance to anti-PD-1 monoc
Autor:
Caroline S. Mifsud, Paul D. King, Norman L. Lehman, George Farmer, Xiaohui Li, Aisulu Usubalieva, Muge Sak, Joseph P. McElroy, Hailey M. Dalton, William M. Bryant, Sara Urio, Cory T. Zumbar
Publikováno v:
Journal of Neuro-Oncology. 137:481-492
Glioblastoma is a highly malignant disease in critical need of expanded treatment options. The AURKA inhibitor alisertib exhibits antiproliferative activity against glioblastoma in vitro and in vivo. Unlike current clinically used taxane drugs, the n
Publikováno v:
Cancer Research. 81:2706-2706
Our work demonstrates RNAscope allows simultaneous quantitative assessment of multiple transcripts in situ using formalin fixed paraffin embedded (FFPE) human non-small cell lung cancer (NSCLC) biopsies and suggests this methodology could be used as
Publikováno v:
Cancer Research. 81:2466-2466
Our work aims to delineate the molecular interactions linking somatic disruption of Serine-Threonine Kinase 11 (STK11) with anti-PD1 therapy resistance in KRAS-driven lung adenocarcinoma (LUAD). Data presented here suggests glutamine synthetase (GLUL
Autor:
Paul D. King, Eric C. Burton, Caroline S. Mifsud, Charles D. Anderson, Cory T. Zumbar, Muge Sak, Joseph P. McElroy, Norman L. Lehman, Arnab Chakravarti, Aisulu Usubalieva, Xiaohui Li, Hailey M Chesnick
Publikováno v:
J Neurooncol
Glioblastoma remains difficult to treat and patients whose tumors express high levels of O6-methylguanine DNA methyltransferase (MGMT) usually respond poorly to standard temozolomide chemotherapy. We have previously shown that the selective AURKA inh
Autor:
Luke O. Buchmann, Jason P. Hunt, Vanessa Torrecillas, Ying J. Hitchcock, Hailey M. Shepherd, Jeffrey J. Houlton, John R. Weis, Richard B. Cannon, Marcus M. Monroe, Donald M. Cannon, Sam Francis, Shane Lloyd
Publikováno v:
Oral oncology. 85
Evaluate current practice patterns in the use of adjuvant radiation for T1-2N1 OCSCC patients and investigate its efficacy in the population-based setting.This study extracted patients who were treated surgically for T1N1 and T2N1 OCSCC without adver