Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Evan R. Simpson"'
Autor:
Sean M. Grimmond, Christine L. Clarke, Aaron G. Smith, Peter J. Leedman, John W. Funder, Joel M. Goode, Peter Bailey, Wayne D. Tilley, Peter J. Fuller, George E.O. Muscat, Dennis H. Dowhan, Natalie A. Eriksson, Tae Gyu Oh, Evan R. Simpson, Eloise Dray
Publikováno v:
Molecular Endocrinology. 28:1166-1185
Protein arginine methyltransferases (PRMTs) methylate arginine residues on histones and target transcription factors that play critical roles in many cellular processes, including gene transcription, mRNA splicing, proliferation, and differentiation.
Autor:
John W. Funder, Elizabeth Kuczek, Evan R. Simpson, George E.O. Muscat, Colin Clyne, Peter J. Leedman, Dinny Graham, Christine L. Clarke, Tram B. Doan, Peter J. Fuller, Natalie A. Eriksson, Wayne D. Tilley
Publikováno v:
Molecular Oncology. 8:998-1013
Although molecular signatures based on transcript expression in breast cancer samples have provided new insights into breast cancer classification and prognosis, there are acknowledged limitations in current signatures. To provide rational, pathway
Autor:
Gareth Baynam, Timothy W. Jones, Evan R. Simpson, Seungmin Ham, Kristy A. Brown, Sarah J Meachem, Adrian Charles, Catherine S. Choong, Nirukshi Udayanga Gunasinghe Samarajeewa
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 98:E1979-E1987
Peutz-Jeghers syndrome (PJS) is an autosomal-dominant disorder that arises as a consequence of mutations in the STK11 gene that encodes LKB1. PJS males often have estrogen excess manifesting as gynecomastia and advanced bone age. We and others have p
Autor:
Christine L. Clarke, Colin Clyne, Kevin Christopher Knower, Natalie A. Eriksson, J. Dinny Graham, Jane E. Visvader, Kiyoshi Takagi, Evan R. Simpson, John W. Funder, Ashwini L. Chand, Geoffrey J. Lindeman, Wayne D. Tilley, Yasuhiro Miki, Hironobu Sasano, Peter J. Fuller, George E.O. Muscat, Peter J. Leedman
Publikováno v:
Breast Cancer Research and Treatment. 142:211-223
The interaction between breast tumor epithelial and stromal cells is vital for initial and recurrent tumor growth. While breast cancer-associated stromal cells provide a favorable environment for proliferation and metastasis, the molecular mechanisms
Publikováno v:
Hormones and Cancer. 4:233-241
The dramatically increased prevalence of breast cancer after menopause is of great concern and is correlated with elevated local levels of estrogens. This is mainly due to an increase in aromatase expression driven by its proximal promoter II (PII).
Publikováno v:
Molecular and Cellular Endocrinology. 366:170-179
AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis involved in the regulation of a number of physiological processes including β-oxidation of fatty acids, lipogenesis, protein and cholesterol synthesis, as well as cell c
Publikováno v:
Cancer research. 76(6)
Publikováno v:
Breast Cancer Research and Treatment. 123:591-596
AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inh
Autor:
Evan R. Simpson, Kristy A. Brown
Publikováno v:
Cancer Research. 70:4-7
Epidemiological evidence supports a correlation between obesity and breast cancer in women. AMP-activated protein kinase (AMPK) is recognized to be a master regulator of energy homeostasis. One of its actions is to phosphorylate and inhibit the actio
Autor:
Robert W. Parkey, Mai Lin, Orhan K. Öz, Xiankai Sun, Zhisu Liu, Gang Ren, Wasana Siyambalapitiyage, Evan R. Simpson, Jun Liu, Asghar Hajibeigi
Publikováno v:
Journal of Nuclear Medicine. 50:1332-1339
Tumor hypoxia is often associated with resistance to chemotherapy. Multidrug resistance type 1 (MDR1) protein is a member of the adenosine triphosphate binding cassette (ABC) proteins, some of which are involved in the multidrug resistance (MDR) phen