Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ernest S. Smith"'
A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non–Small Cell Lung Cancer
Autor:
Rachel E. Sanborn, John E. Leonard, Crystal Mallow, Megan Ann Baumgart, Andreas Schröder, Nashat Y. Gabrail, Aaron S. Mansfield, Jonathan W. Goldman, Maurice Zauderer, Nagashree Seetharamu, JT Beck, Michael Shafique, Elizabeth E. Evans, Desa Rae Pastore, Ramaswamy Govindan, Ernest S. Smith, Kevin M. Chin, Yanyan Lou, Terrence L. Fisher, Vikas Mishra, Alexander I. Spira
Publikováno v:
Clinical Cancer Research. 27:3630-3640
Purpose: The CLASSICAL-Lung clinical trial tested the combination of pepinemab, an IgG4 humanized mAb targeting semaphorin 4D, with the PD-L1 inhibitor avelumab to assess the effects of coupling increased T-cell infiltration and reversal of immune su
Autor:
John E. Leonard, Elizabeth E. Evans, Marya F. Chaney, Terrence L. Fisher, Maurice Zauderer, Amber Foster, Ernest S. Smith, Crystal Mallow
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundImmunosuppressive myeloid cells in the tumor microenvironment (TME) are a critical limitation to the efficacy of immune checkpoint inhibitors (ICIs) in patients with head and neck squamous cell carcinoma (HNSCC). Both semaphorin 4D (SEMA4D,
Autor:
Leslie Balch, Vikas Mishra, Andrew Feigin, Terrence L. Fisher, Alan Howell, Eric Siemers, John E. Leonard, Elizabeth E. Evans, Alisha M. Reader, Maurice Zauderer, Crystal Mallow, Ernest S. Smith
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Andrew Lake, Christopher Converse Wells, Bijan Etemad-Gilbertson, Austin Dulak, Das Sonia, Vito J. Palombella, Warren Michael, Ernest S. Smith, Pamela M. Holland, Maria Scrivens
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background T regulatory cells (Tregs) are potent suppressors of immune activation in the periphery and tumor microenvironment (TME). Tumor-infiltrating Tregs have also been associated with resistance to cancer therapies. Loss of peripheral Tregs can
Autor:
Ernest S. Smith, Ellen C. Moore, Paul E. Clavijo, Maurice Zauderer, Jay Friedman, Elizabeth E. Evans, Clint T. Allen, Yvette Robbins
Publikováno v:
Cancer Immunol Res
Tumor infiltration by immunosuppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs), causes resistance to immunotherapy. Semaphorin4D, originally characterized for its axonal guidance properties, also contributes to endothelial ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a5e595af9e355bf17f4ded5c580fd9
https://europepmc.org/articles/PMC8326929/
https://europepmc.org/articles/PMC8326929/
Autor:
Kevin M. Chin, Jonathan W. Goldman, Alexander I. Spira, Nashat Y. Gabrail, Thaddeaus Beck, Rachel E. Sanborn, John E. Leonard, Terrence L. Fisher, Ernest S. Smith, Yanyan Lou, Megan Ann Baumgart, Maurice Zauderer, Ramaswamy Govindan, Elizabeth E. Evans, Desa Rae Pastore, Nagashree Seetharamu, Michael Shafique, Crystal Mallow, Aaron S. Mansfield, Andreas Schroeder
Publikováno v:
Cancer Research. 80:CT191-CT191
Despite progress of immune checkpoint therapies, many cases of non-small cell lung cancer (NSCLC) are refractory or acquire resistance to current therapies. Antibody blockade of semaphorin 4D (SEMA4D, CD100) can overcome resistance mechanisms of immu
Autor:
Michael C. Lowe, Clint T. Allen, Nabil F. Saba, Christina Wu, Ernest S. Smith, Conor E. Steuer, John E. Leonard, Paul E. Clavijo, Gregory B. Lesinski, Desa Rae Pastore, Brian Olson, Elizabeth E. Evans, Crystal Mallow, Ragini R. Kudchadkar, Terrence L. Fisher, Maurice Zauderer
Publikováno v:
Clinical Cancer Research. 26:A15-A15
Recruitment of immunosuppressive myeloid cells into the tumor microenvironment (TME) is a critical limitation to the efficacy of immune checkpoint inhibitors (ICIs) in patients with head and neck squamous cell carcinoma (HNSCC). In preclinical models
Autor:
Desa Rae Pastore, Kevin M. Chin, Nashat Y. Gabrail, JT Beck, Aaron S. Mansfield, Andreas Schröder, Alexander I. Spira, Yanyan Lou, Michael Shafique, Crystal Mallow, Megan Ann Baumgart, Terrence L. Fisher, Ernest S. Smith, Rachel E. Sanborn, Nagashree Seetharamu, Maurice Zauderer, Elizabeth E. Evans, Ramaswamy Govindan, John E. Leonard, Jonathan W. Goldman
Publikováno v:
Journal of Clinical Oncology. 38:3011-3011
3011 Background: Antibody blockade of semaphorin 4D (SEMA4D, CD100) promotes tumoral dendritic cell and CD8+ T cell infiltration and reduces function and recruitment of immunosuppressive myeloid cells. Importantly, these mechanisms to overcome immune
Autor:
Gregory B. Lesinski, Mihir R. Patel, Brian Olson, Crystal Mallow, Michael C. Lowe, Ragini R. Kudchadkar, Conor E. Steuer, Elizabeth E. Evans, John E. Leonard, Terrence L. Fisher, Christina Wu, Maurice Zauderer, Desa Rae Pastore, Nabil F. Saba, Ernest S. Smith
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 106:1175
Autor:
Andreas Schröder, Ramaswamy Govindan, Elizabeth E. Evans, Jonathan W. Goldman, John E. Leonard, Nagashree Seetharamu, Kevin M. Chin, Megan Ann Baumgart, Desa Rae Pastore, Yan Yan Lou, Rachel E. Sanborn, Aaron S. Mansfield, Nashat Y. Gabrail, Terrence L. Fisher, J. Thaddeus Beck, Ernest S. Smith, Maurice Zauderer, Alexander I. Spira, Crystal Mallow, Michael Shafique
Publikováno v:
Journal of Clinical Oncology. 38:75-75
75 Background: Despite progress of immune checkpoint therapies, many cases of non-small cell lung cancer (NSCLC) are refractory or acquire resistance to current therapies. Antibody blockade of semaphorin 4D (SEMA4D, CD100) can overcome resistance mec