Zobrazeno 1 - 10
of 87
pro vyhledávání: '"David L. Huso"'
Autor:
Karen L. Reddy, Linda M.S. Resar, Lionel Chia, Leslie Cope, Ruitao Zhang, Shuai Shuai, David L. Huso, Tait Huso, Jung Hyun Kim, Lingling Xian
Publikováno v:
Cancer Research. 80:297-297
Pancreatic ductal adenocarcinomas (PDACs) are highly lethal tumors characterized by a dense desmoplastic stroma comprised of cancer associated fibroblasts (CAFs) and fibrotic scar tissue. While stromal CAFs provide a barrier to therapy and release si
Autor:
Alfred Morgenstern, Zhe Zhang, Takahiro Yoshida, Hong Song, Sunju Park, Han Liangfeng, Charles Zhu, Saraswati Sukumar, Frank Bruchertseifer, Kideok Jin, George Sgouros, David L. Huso
Publikováno v:
Oncotarget
The standard treatment for ductal carcinoma in situ (DCIS) of the breast is surgical resection, followed by radiation. Here, we tested localized therapy of DCIS in mice using the immunoconjugate 225Ac linked-trastuzumab delivered through the intraduc
Autor:
Liangfeng Han, Helen Sadik, Yolanda M.N. Foster, Duojia Pan, Angela Brodie, Zhe Zhang, Syed Z. Ali, Peter Ordentlich, David L. Huso, Christina Adams, Roisin M. Connolly, Soonweng Cho, Vered Stearns, Nguyen Nguyen, Preethi Korangath, Kideok Jin, Saraswati Sukumar, Xian C. Zhou, Qian Chen, Vanessa F. Merino
Publikováno v:
Cancer Research. 76:2013-2024
Efforts to induce the differentiation of cancer stem cells through treatment with all-trans retinoic acid (ATRA) have yielded limited success, partially due to the epigenetic silencing of the retinoic acid receptor (RAR)-β. The histone deacetylase i
Autor:
Michael Koo, James Turkson, David L. Huso, Tait Huso, Patrick T. Gunning, Lingling Xian, Guosheng Liu, Brent D. G. Page, Amy Belton, Li Z. Luo, Linda M.S. Resar
Publikováno v:
Leukemia & Lymphoma. 57:2681-2684
Despite dramatic improvements in treatment and survival, acute lymphoid malignancies remain the leading cause of death in children with cancer and a highly lethal malignancy in adults.[1] Acute lym...
Autor:
Fengyi Wan, Paul Metz, Sudipto Ganguly, Drew M. Pardoll, Hongni Fan, Christina E. DeStefano Shields, David L. Huso, Florencia McAllister, Kai Fu, Shaoguang Wu, Benjamin B. Finard, June Chan, Payam Fathi, Jie Chen, Ada J. Tam, Cynthia L. Sears, Franck Housseau, Christine M. Dejea, Abby L. Geis, Elizabeth C. Wick, Sara W. Van Meerbeke, Liam Chung, Erik Thiele-Orberg, Xinqun Wu
Publikováno v:
SSRN Electronic Journal.
Pro-carcinogenic bacteria have the potential to initiate and/or promote human colon cancer. However, the mechanism(s) by which a bacterium may trigger carcinogenesis remains unclear. Herein, we show Bacteroides fragilis toxin (BFT) secretion by the h
Autor:
David L. Huso, Stuart W. Smith, Hannah Louise Morris, Caroline O. S. Savage, Amy J. Naylor, Christopher D. Buckley, Adam P. Croft, Clare M. Isacke
Publikováno v:
Nephron. 131:265-277
Background: Tissue fibrosis and microvascular rarefaction are hallmarks of progressive renal disease. CD248 is a transmembrane glycoprotein expressed by key effector cells within the stroma of fibrotic kidneys including pericytes, myofibroblasts and
Autor:
David L. Huso, Saraswati Sukumar, Nguyen Nguyen, Lionel Feigenbaum, Pedram Argani, Manfred Gessler, Göran Landberg, Soonweng Cho, Scott L. Kominsky, Preethi Korangath, Wei Wen Teo, Adam Diehl, Liangfeng Han, Alan Rein
Publikováno v:
Cancer Research. 74:6509-6518
Acquired resistance to TGFβ is a key step in the early stages of tumorigenesis. Mutations in TGFβ signaling components are rare, and little is known about the development of resistance in breast cancer. On the other hand, an activated Notch pathway
Autor:
Michael J. Parsons, Mathieu Lévesque, David L. Huso, Joon Tae Park, Nicole M. Johnson, Yue J. Wang, Steven D. Leach, Anirban Maitra, Shu Liu, Jason D. Prescott, Hao Ho
Publikováno v:
Oncogene
Somatic activation of the KRAS proto-oncogene is evident in almost all pancreatic cancers, and appears to represent an initiating event. These mutations occur primarily at codon 12 and less frequently at codons 13 and 61. Although some studies have s
Autor:
Hangxue Xu, Javid Moslehi, Connie Wang, Gregory G. Germino, David L. Huso, Jennifer P Habashi, Dongyan Liu, Terry Watnick, Marc K. Halushka, Daniel P. Judge, Kathleen L. Gabrielson, Feng Qian, Harry C. Dietz, Djahida Bedja, Jie Ni
Publikováno v:
Journal of the American Society of Nephrology. 25:81-91
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of renal failure that is due to mutations in two genes, PKD1 and PKD2. Vascular complications, including aneurysms, are a well recognized feature of ADPKD, and a subgroup of famil
Autor:
Linda M.S. Resar, Sujayita Roy, Francescopaolo Di Cello, David L. Huso, Jules P.P. Meijerink, Ossama Elbahloul, Jeanne Kowalski, Joelle Hillion, Richard S. Larson, Alexandra C. Hristov, Surajit Dhara, Stuart S. Winter
Publikováno v:
Leukemia & Lymphoma, 54(8), 1762-1768. Informa Healthcare
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia with high relapse rates compared to B-lineage ALL. We previously showed that HMGA1a transgenic mice develop aggressive T-ALL, indicating that HMGA1 causes leukemic transformation i