Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Cheryl H. Arrowsmith"'
Autor:
Nhat Tran, Heather Whetstone, Ian Restall, Patty Sachamitr, Julian Spears, Jasmin Coulombe-Huntington, Joseph Veyhl, Gary D. Bader, Mark Bernstein, Ahmed Aman, Mike Tyers, Hannes L. Röst, Sunit Das, Kirsten Hart, Bang-Chi Duong, Zahid Quyoom Bonday, Mathieu Lupien, Peter B. Dirks, Cheryl H. Arrowsmith, Maria M. Mangos, Laura M. Richards, Owen Whitley, Paul Guilhamon, María Sánchez-Osuna, H. Artee Luchman, Trevor J. Pugh, Jolene Caifeng Ho, Michael D. Cusimano, Samuel Weiss, Philippe Thibault, Amy Caudy, Olga Zaslaver, Panagiotis Prinos, Fiona J. Coutinho, Florence M.G. Cavalli, Wenjun Chen, Victoria Vu, Dalia Barsyte-Lovejoy, Xiaoyang Lan, Xinghui Che, Mathieu Durand, Michelle Kushida, Naghmeh Rastegar, Katlin B. Massirer, Benjamin Haibe-Kains, Lilian Lee, Evgeny Kanshin, Wail Ba-alawi, Felipe Ciamponi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Glioblastoma (GBM) is a deadly cancer in which cancer stem cells (CSCs) sustain tumor growth and contribute to therapeutic resistance. Protein arginine methyltransferase 5 (PRMT5) has recently emerged as a promising target in GBM. Using two orthogona
Autor:
Wail Ba-alawi, Evelyne Lima-Fernandes, Jason W. Locasale, Daniel D. De Carvalho, Paul Savage, Ilias Ettayebi, Hellen Kuasne, Morag Park, Felicia Tai, Yunchi Ingrid Kao, Benjamin Haibe-Kains, Alexandra N. Fedor, Paul Guilhamon, Giacomo Grillo, Seyed Ali Madani Tonekaboni, Cheryl H. Arrowsmith, Xiaojing Liu, Constanza Martinez, Anne-Marie Fortier, Mathieu Lupien, Alex Murison, Geneviève Deblois, David W. Cescon
Publikováno v:
Cancer Discovery. 10:1312-1329
Tumor progression upon treatment arises from preexisting resistant cancer cells and/or adaptation of persister cancer cells committing to an expansion phase. Here, we show that evasion from viral mimicry response allows the growth of taxane-resistant
Autor:
Cheryl H. Arrowsmith, Jocelyn Chen, Nergiz Artun, Jian Jin, Magdalena M. Szewczyk, Jing Liu, Wail Ba alawi, Qin Wu, David W. Cescon, Felipe Ciamponi, Geneviève Deblois, Daniel D. De Carvalho, Lan Xin Zhang, Jennifer Cruickshank, Parinaz Mehdipour, Katlin Maussirer, Dalia Barsyte-Lovejoy, Panagiotis Prinos, Sajid A. Marhon, Benjamin Haibe-Kains, Shili Duan, Wenjun Chen, Mathieu Lupien, David Y Nie, YiShuai Ji, Yudao Shen, Jillian Haight
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis and few effective therapies. Here, we undertook a screen of epigenetic chemical probes to systematically uncover the epigenetic regulators crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01de5bbaa1f1a3526246a5ddb617665
https://ora.ox.ac.uk/objects/uuid:4e028a21-2cb6-4b3d-a99d-fcdce5a080d9
https://ora.ox.ac.uk/objects/uuid:4e028a21-2cb6-4b3d-a99d-fcdce5a080d9
Autor:
Zhen Wang, Jiemin Wong, Jiwen Li, Peter Brown, Lan Fang, Cheryl H. Arrowsmith, Yuanyong Huang, Li Kang, Menghan Li, Huifang Zhang
Publikováno v:
Oncogene. 38:5250-5264
As a transcription factor critical for embryonic and adult stem cell self-renewal and function, SOX2 gene amplification has been recognized as a driving factor for various cancers including esophageal cancer. SOX2 overexpression occurs more broadly i
Autor:
Anne Hakem, Parasvi S. Patel, Jonathan St-Germain, Marie-jo Halaby, Razqallah Hakem, Francesca Mateo, Daniel R. Barnes, Jonathan Beesley, Haithem Barbour, Karim Mekhail, Miquel Angel Pujana, El Bachir Affar, Cheryl H. Arrowsmith, Brian Raught, Samah El Ghamrasni, Arash Algouneh, Kiran Kumar Naidu Guturi, Otto Sanchez, Brandon Ho, Georgia Chenevix-Trench, Shili Duan, Antonis C. Antoniou, Zahra Khan, Karan J. Abraham, Hal K. Berman, Grant W. Brown, Luis Palomero
Publikováno v:
J Clin Invest
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes considerably increase breast and ovarian cancer risk. Given that tumors with these mutations have elevated genomic instability, they exhibit relative vulnerability to certain chemotherapies and ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fe09874518ecab3f221c045d16ccb1
https://www.repository.cam.ac.uk/handle/1810/317678
https://www.repository.cam.ac.uk/handle/1810/317678
Autor:
Hassan Mahmoud, Yan Nie, Benjamin Haibe-Kains, Mathieu Lupien, Jillian Haight, Susan J. Done, Peter B. Dirks, Evelyne Lima-Fernandes, Bradly G. Wouters, Nergiz Dogan-Artun, David W. Cescon, Wenjun Chen, Jennifer Cruickshank, Wail Ba-alawi, Trevor D. McKee, Stanley Zhou, Michelle Kushida, Seyed Ali Madani Tonekaboni, Shili Duan, Ravi N. Vellanki, Cheryl H. Arrowsmith, Panagiotis Prinos, Geneviève Deblois, Morag Park, Qin Wu, Lan Xin Zhang, Hellen Kuasne, Anne-Marie Fortier, Sarina Cameron
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expres
Autor:
Samuel Weiss, Leo J.Y. Kim, Xiaochong Wu, Randy Van Ommeren, Yanqing Jiang, Kaitlin Kharas, Evgeny Kanshin, Moloud Ahmadi, Alberto Delaidelli, Geneviève Deblois, David Przelicki, Stephane Angers, Hiromichi Suzuki, Sameer Agnihotri, Bradly G. Wouters, Graham MacLeod, Ricky Tsai, Pasqualino De Antonellis, Michelle Ly, Stacey L. Krumholtz, Paul Guilhamon, James Loukides, Ravi N. Vellanki, Alex Rasnitsyn, Hamza Farooq, Daniel Schramek, Nada Jabado, María Sánchez-Osuna, Laura K. Donovan, Vijay Ramaswamy, Ibrahim El-Hamamy, Joonas Haapasalo, Jeremy N. Rich, Michael D. Taylor, Benjamin A. Garcia, Mike Tyers, Kyle Juraschka, Winnie Ong, Olivier Saulnier, Panagiotis Prinos, John J.Y. Lee, Borja L. Holgado, Olga Sirbu, Craig Daniels, Cheryl H. Arrowsmith, Cory Richman, Poul H. Sorensen, Kulandaimanuvel Antony Michealraj, Sheila K. Singh, Andrea Bajic, Polina Balin, Stephen C. Mack, Betty Luu, Fiona J. Coutinho, Dilakshan Srikanthan, Florence M.G. Cavalli, Sachin Kumar, Evan Y. Wang, Mathieu Lupien, Peter B. Dirks, Maria C. Vladoiu, Lincoln Stein, Livia Garzia, Ahmad Malik, John Wojcik, Avesta Rastan
Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are lacking. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4cbadadef8c1b79cfc6c9ec6f333d8
https://hdl.handle.net/11588/900834
https://hdl.handle.net/11588/900834
Autor:
David W. Cescon, Susan J. Done, Ravi N. Vellanki, Nergiz Dogan-Artun, Sarina Cameron, Wenjun Chen, Wail Ba-alawi, Qin Wu, Benjamin Haibe-Kains, Stanley Zhou, Mathieu Lupien, Shili Duan, Morag Park, Hellen Kuasne, Hassan Mahmoud, Geneviève Deblois, Cheryl H. Arrowsmith, Jennifer Cruickshank, Trevor D. McKee, Seyed Ali Madani Tonekaboni, Evelyne Lima-Fernandes, Anne-Marie Fortier, Jillian Haight
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f09514f499437016415264caafd72f
https://doi.org/10.1101/764944
https://doi.org/10.1101/764944
Autor:
Gennady Poda, Marko Jakopović, Levon Halabelian, Methvin Isaac, Nikolina Radulovich, Michael Prakesch, Caroline Huard, Ahmed Aman, Dhananjay Joshi, Zhong Yao, Manuel Chan, Wiebke Schormann, Richard Marcellus, Babu Joseph, Rima Al-awar, Luka Drecun, Mohammed Mohammed, Li Niu, Brigitte L. Thériault, María Sánchez-Osuna, David Uehling, Ahmed Mamai, Ming-Sound Tsao, Jasmin Coulombe-Huntington, Taira Kiyota, Evelyne Lima-Fernandes, Punit Saraon, Ankit Rai, Jamie Snider, David W. Andrews, Cheryl H. Arrowsmith, Farzaneh Aboualizadeh, Natasha B. Leighl, Miroslav Samaržija, Victoria Wong, Anna Lyakisheva, Mike Tyers, Ratheesh Subramanian, Adrian G. Sacher, Fengling Li, Masoud Vedadi, Igor Stagljar, Shivanthy Pathmanathan
Publikováno v:
Journal of Molecular Biology. 433:167294
Activating mutations in the epidermal growth factor receptor (EGFR) are common driver mutations in non-small cell lung cancer (NSCLC). First, second and third generation EGFR tyrosine kinase inhibitors (TKIs) are effective at inhibiting mutant EGFR N
Autor:
Tiziana Bonaldi, Cheryl M. Koh, Cheryl H. Arrowsmith, Christine Thompson, Heike Wollmann, Bas J. Wouters, Luca Pignata, Jia Yi Fong, Magdalena M. Szewczyk, Ari Melnick, Dalia Barsyte-Lovejoy, Daniele Musiani, Cheng Mun Wun, Alex Penson, Pierre-Alexis Goy, Jian Jin, Eirini P. Papapetrou, Mark D. Minden, Enrico Massignani, Genna M. Luciani, Omar Abdel-Wahab, Olena Barbash, Ernesto Guccione, Ruud Delwel, Diana Hp. Low, Michelle Ki, Alexander Rialdi, Kimihito Cojin Kawabata, Andriana G. Kotini, Timothy K. Hart, Megan C. Schwarz, Slim Mzoughi, Yudao Shen, Stanley Chun-Wei Lee
Publikováno v:
Cancer Cell, 36(2), 194-+. Cell Press
Cancer Cell
Cancer Cell
Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type splicing. These observations have led to clinical efforts to directly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abc1c9ad1c9c46107e079dc43598e0c
https://pure.eur.nl/en/publications/4ea6f5b5-7be9-43d4-bebe-69e3c9d77205
https://pure.eur.nl/en/publications/4ea6f5b5-7be9-43d4-bebe-69e3c9d77205