Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Bhagwat, A"'
Autor:
Alexei V. Trofimov, Mary E. Aronow, Evangelos S. Gragoudas, Florence K. Keane, Ivana K. Kim, Helen A. Shih, Mandar S. Bhagwat
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 115:501-510
Autor:
Nina Richartz, Wojciech Pietka, Karin M. Gilljam, Seham Skah, Bjørn S. Skålhegg, Sampada Bhagwat, Elin Hallan Naderi, Ellen Ruud, Heidi Kiil Blomhoff
Publikováno v:
Molecular Cancer Research. 20:400-411
DNA-damaging therapy is the basis for treatment of most cancers, including B-cell precursor acute lymphoblastic leukemia (BCP-ALL, hereafter ALL). We have previously shown that cAMP-activating factors present in the bone marrow render ALL cells less
Autor:
Hem Chandra Jha, Hamendra Singh Parmar, Rajesh Sharma, Pramod K. Gavel, Aakruti Nayak, Shivani Bhagwat
Publikováno v:
Current Cancer Drug Targets. 21:575-600
Cancer patients are more susceptible to COVID-19; however, the prevalence of COVID-19 in different types of cancer is still inconsistent and inconclusive. Here, we delineate the intricate relationship between breast cancer and COVID-19. Breast cancer
Autor:
Anjana Agarwal, Olusola Peace Osinubi, Komali Vykuntam, Norman Fultang, Neha Bhagwat, Diane Heiser, Kris Vaddi, Koichi Ito, Peggy Scherle
Publikováno v:
Cancer Research. 83:1594-1594
Dysregulated cellular differentiation is a major pathological feature of myeloid malignancies such as acute myeloid leukemia (AML). Targeting cellular differentiation programs has emerged as a novel therapeutic approach to treat patients with AML. Ad
Autor:
Norman Fultang, Brian Vidal, Ashley M. Schwab, Alexander Grego, Diane Heiser, Kris Vaddi, Neha Bhagwat, Peggy Scherle
Publikováno v:
Cancer Research. 83:6147-6147
Induced myeloid leukemia cell differentiation protein (MCL1) is a member of the B-cell lymphoma-2 (BCL2) family of apoptosis regulators, which plays a critical role in maintaining cellular homeostasis and promoting cancer cell survival. Increased exp
Autor:
Koichi Ito, Artem Shvartsbart, Joseph Rager, Anjana Agarwal, Michael Hulse, Komali Vykuntam, Min Wang, Justin Kurian, Miles Cowart, Joy Cote, Monisha Sivakumar, Jack Carter, Jessica Burtell, Alex Grego, Andrew Moore, Neha Bhagwat, Stefan Ruepp, Tom Emme, Liang Lu, Philip Pitis, Corey Basch, Klare Bersch, Song Mei, Raul Leal, John Rose, Danielle Roth, Ganfeng Cao, Kris Vaddi, Sandy Geeganage, Bruce Ruggeri, Andrew Combs, Peggy Scherle
Publikováno v:
Cancer Research. 83:6277-6277
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to target previously undruggable targets. However, it has been more challenging to identify orally bioavailable TPD molecules due to the physicochemical propert
Autor:
Gowhar Shafi, Atul Bharde, Fauzul Moubeen, Kanchan Hariramani, Alain D’Souza, Trupti Kad, Bhagwat Jadhav, Sangita Prajapati, Aditi Rani, Madhura Basavalingegowda, Mohan Uttarwar, Gourishankar Aland, Sreeja Jayant, Aravindan Vasudevan, Pankaj Chaturvedi, Jayant Khandare
Publikováno v:
Cancer Research. 83:3379-3379
Comprehensive CtDNA and CTC profiling of treatment naïve early-stage head and neck cancer patients reveals early signatures of disease progressionBackground: We performed comprehensive ctDNA analysis on early-stage HNC patients in a pilot study to d
Autor:
Andrew Moore, Carly Bachner, Lalitha Srinivasan, Pradeep Kurup, Alex Grego, Caroline Vitkovitsky, Koichi Ito, Neha Bhagwat, Peggy Scherle
Publikováno v:
Cancer Research. 83:2792-2792
The SWI/SNF complex plays an important role in controlling gene expression via chromatin remodeling. One of its catalytic subunits, SMARCA4, is frequently mutated in multiple tumor types, and SMARCA4-deficient cells are highly dependent on the other
Autor:
Mohamad K. Hammoud, Raimund Dietze, Jelena Pesek, Florian Finkernagel, Annika Unger, Tim Bieringer, Andrea Nist, Thorsten Stiewe, Aditya M. Bhagwat, Wolfgang Andreas Nockher, Silke Reinartz, Sabine Müller‐Brüsselbach, Johannes Graumann, Rolf Müller
Publikováno v:
Molecular oncology. 16(17)
Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163
Autor:
Margaret K. Wilkens, Monica Musteanu, Aine Knott, Magda Bahcall, Shripad V. Bhagwat, Kara M. Soroko, Prafulla C. Gokhale, Jens Köhler, Emily S. Chambers, Mika Lin, Yutong Zhao, Hong L. Tiv, Jihyun Choi, Jason Manro, Ramon V. Tiu, Arrien A. Bertram, Pasi A. Jänne, Atsuko Ogino, Cloud P. Paweletz, Jiaqi Li, Chiara Ambrogio
Publikováno v:
Molecular Cancer Therapeutics. 20:641-654
RAS gene mutations are the most frequent oncogenic event in lung cancer. They activate multiple RAS-centric signaling networks among them the MAPK, PI3K, and RB pathways. Within the MAPK pathway, ERK1/2 proteins exert a bottleneck function for transm