Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alisha Holtzhausen"'
Publikováno v:
Cancer Immunology Research. 10:B45-B45
Tyro3, Axl and MerTK (TAM) are a family of receptor tyrosine kinases (RTKs) that play physiologic roles in dampening innate immune responses, preventing chronic inflammation and autoimmunity. Their roles in potentially promoting tolerance in the immu
Autor:
Cameron J. Oswalt, Rami N. Al-Rohil, Bala Theivanthiran, Tarek Haykal, April K.S. Salama, Nicholas C. DeVito, Alisha Holtzhausen, Dennis C. Ko, Brent A. Hanks
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 45(6)
The mechanisms underlying tumor immunosurveillance and their association with the immune-related adverse events (irAEs) associated with checkpoint inhibitor immunotherapies remain poorly understood. We describe a metastatic melanoma patient exhibitin
Autor:
Linda Cao, Tarek Haykal, Alisha Holtzhausen, Brent A. Hanks, Nicholas DeVito, Michael Plebanek, Balamayooran Theivanthiran
Publikováno v:
Cancers
Cancers, Vol 13, Iss 4753, p 4753 (2021)
Cancers, Vol 13, Iss 4753, p 4753 (2021)
Simple Summary The tumor-intrinsic NLRP3 inflammasome is a newly recognized player in the regulation of tumor-directed immune responses and promises to provide fresh insight into how tumors respond to immunotherapy. This brief review discusses recent
Autor:
Michael Plebanek, Brent A. Hanks, Michael Sturdivant, Veronica Novotny-Diermayr, Christine Xiao, April K.S. Salama, Nicholas DeVito, Balamayooran Thievanthiran, Georgia M. Beasley, John H. Strickler, Alisha Holtzhausen
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 5, Pp 109071-(2021)
Cell Reports, Vol 35, Iss 5, Pp 109071-(2021)
SUMMARY While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin pathway is associated with diminished T cell infiltration; howe
Autor:
Balachandra K. Gorentla, Patrick L. Leslie, Trent A. Waugh, D. Neil Hayes, Jared Weiss, Albert S. Baldwin, Emily B. Harrison, Subrata K. Ghosh, Alessandro Porrello, Yvonne L. Chao, Michele C. Hayward, Alisa S. Wolberg, Sravya Kattula, Alisha Holtzhausen, Matthew D. Wilkerson, Cecilia Oderup, Chad V. Pecot, Liza Makowski, Virginia Godfrey, Sanggyu Bae, Scott H. Randell, H. Shelton Earp, Salma H. Azam
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Nature Communications
Nature Communications
Lung cancer is the leading cause of cancer-related deaths worldwide, and lung squamous carcinomas (LUSC) represent about 30% of cases. Molecular aberrations in lung adenocarcinomas have allowed for effective targeted treatments, but corresponding the
Autor:
Yubin Kang, Douglas B. Johnson, April K.S. Salama, Balamayooran Theivanthiran, Andrew B. Nixon, Mark D. Starr, Lucas P. Wachsmuth, Michael Sturdivant, David Hsu, Alisha Holtzhausen, Brent A. Hanks, Kathy Evans, Michael Plebanek, Justin M. Balko, Nicholas DeVito
Publikováno v:
J Clin Invest
An in-depth understanding of immune escape mechanisms in cancer is likely to lead to innovative advances in immunotherapeutic strategies. However, much remains unknown regarding these mechanisms and how they impact immunotherapy resistance. Using sev
Autor:
Yuewei Zhang, Jichen Zhao, William T. Harris, Dehui Zhang, Douglas K. Graham, Qingyang Liu, Debra Hunter, H. Shelton Earp, Stephen V. Frye, Eric Ubil, Xiaodong Wang, Alisha Holtzhausen
Myeloid cell receptor tyrosine kinases TYRO3, AXL, and MERTK and their ligands, GAS6 and PROTEIN S, physiologically suppress innate immune responses, including in the tumor microenvironment. Here, we showed that myeloid-derived suppressor cells (MDSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66dd3450e43943b2bb6928312c00be49
https://europepmc.org/articles/PMC6943983/
https://europepmc.org/articles/PMC6943983/
Autor:
Alisha Holtzhausen, Fei Zhao, Ciriana Orabona, Brent A. Hanks, Masahito Tsutsui, Kathy Evans, Douglas S. Tyler
Publikováno v:
Cancer Immunology Research. 3:1082-1095
The β-catenin signaling pathway has been demonstrated to promote the development of a tolerogenic dendritic cell (DC) population capable of driving regulatory T-cell (Treg) differentiation. Further studies have implicated tolerogenic DCs in promotin
Autor:
Charlotte Story, H. Shelton Earp, Debra Hunter, Eric Ubil, Laura S. Caskey, Alisha Holtzhausen
Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In contrast, tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33877fbbaf320381a7881649e7550d2a
https://europepmc.org/articles/PMC5983338/
https://europepmc.org/articles/PMC5983338/
Autor:
Gerard C. Blobe, Brent A. Hanks, Nicholas DeVito, Fei Zhao, Peter J. Siska, Christine Xiao, Kathy Evans, Balamayooran Theivanthiran, Alisha Holtzhausen
Publikováno v:
Cancer immunology research. 6(12)
Although anti–PD-1 therapy has improved clinical outcomes for select patients with advanced cancer, many patients exhibit either primary or adaptive resistance to checkpoint inhibitor immunotherapy. The role of the tumor stroma in the development o