Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexander J. Towbin"'
Autor:
Eugene D. McGahren, M. Beth McCarville, Howard M. Katzenstein, Carlos Rodriguez-Galindo, Rebecka L. Meyers, Jin Piao, Wayne L. Furman, Nadia Chung, Christopher B. Weldon, Mark Krailo, Alexander J. Towbin, Patrick A. Thompson, Allison F. O'Neill, Sarangarajan Ranganathan, Stephen P. Dunn, Marcio H. Malogolowkin, Milton J. Finegold, Jessica Randazzo, Angela D. Trobaugh-Lotrario, Max R. Langham, Gregory M. Tiao
Publikováno v:
Cancer
Background The Children's Oncology Group (COG) adopted cisplatin, 5-flourouracil, and vincristine (C5V) as standard therapy after the INT-0098 legacy study showed statistically equivalent survival but less toxicity in comparison with cisplatin and do
Autor:
Anasua Roshni Dasgupta, Gregory M. Tiao, Todd M. Jenkins, Alexander J. Towbin, Charissa M. Lake, Alexander Bondoc, Maria H. Alonso, Ethan A. Smith, James I. Geller
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 13, Pp 4322-4343 (2021)
Cancer Medicine, Vol 10, Iss 13, Pp 4322-4343 (2021)
Background Hepatoblastoma is the most common primary pediatric liver malignancy. Indocyanine green (ICG) has been described as an adjunct to resection in small series. Its utility remains undefined in larger cohorts. Methods Records for 29 patients d
Autor:
Angela Trobaugh-Lotrario, Howard M. Katzenstein, Sarangarajan Ranganathan, Dolores Lopez-Terrada, Mark D. Krailo, Jin Piao, Nadia Chung, Jessica Randazzo, Marcio H. Malogolowkin, Wayne L. Furman, Elizabeth B. McCarville, Alexander J. Towbin, Greg M. Tiao, Stephen P. Dunn, Max R. Langham, Eugene D. McGahren, James Feusner, Carlos Rodriguez-Galindo, Rebecka L. Meyers, Allison F. O'Neill, Milton J. Finegold
Publikováno v:
J Clin Oncol
PURPOSE Small cell undifferentiated (SCU) histology in hepatoblastoma (HB) tumors has historically been associated with a poor prognosis. Tumors from patients enrolled on Children's Oncology Group (COG) study AHEP0731 underwent institutional and cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b696c663417d4d1d11dbc92097377d
https://europepmc.org/articles/PMC8824398/
https://europepmc.org/articles/PMC8824398/
Autor:
Teresa de Rojas, Fernando Carceller, L Moreno, Francisco Bautista, Anouk Neven, David Riedl, Ana Fernández-Teijeiro, Anne-Sophie Darlington, Samantha C. Sodergren, Alexander J. Towbin
Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369feafc53aa035fe5681684f6ab5468
https://eprints.soton.ac.uk/437285/1/Clinical_research_tools_in_pediatric_oncology_challenges_and_opportunities.docx
https://eprints.soton.ac.uk/437285/1/Clinical_research_tools_in_pediatric_oncology_challenges_and_opportunities.docx
Autor:
Wayne L. Furman, Mark Krailo, M. Beth McCarville, Christopher B. Weldon, Eugene D. McGahren, Sarangarajan Ranganathan, Carlos Rodriguez-Galindo, Alexander J. Towbin, Allison F. O'Neill, Greg Tiao, Marcio H. Malogolowkin, Max R. Langham, Rebecka L. Meyers, Caihong Xia, Yun Gao, Milton J. Finegold, Stephen P. Dunn, Howard M. Katzenstein
Publikováno v:
Journal of Clinical Oncology. 35:3465-3473
Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates with outcome. Methods Thirty-two patients with metastatic HB were enrolled on Children’s Oncology Group Protocol AHEP0731 and treate
Autor:
Eugene D. McGahren, Greg Tiao, Stephen P. Dunn, Howard M. Katzenstein, Milton J. Finegold, Wayne L. Furman, Carlos Rodriguez-Galindo, Alexander J. Towbin, Sarangarajan Ranganathan, Mark Krailo, Rebecka L. Meyers, M. Beth McCarville, Marcio H. Malogolowkin, Max R Langham
Publikováno v:
Cancer. 123:2360-2367
BACKGROUND The identification of new therapies for high-risk (HR) hepatoblastoma is challenging. Children's Oncology Group study AHEP0731 included a HR stratum to explore the efficacy of novel agents. Herein, the authors report the response rate to t
Autor:
Kristy Ott-Napier, Kathleen Simpson, Michele R. Vaughan, Lori Backus, John M. Racadio, Patrick Warren, Robert Spavin, Devon J. Dishman, Beth Stockman, James I. Geller, Joe Conner, Keri A. Streby, Marianne M Brunner, Alexander J. Towbin, Mark A. Currier, Timothy P. Cripe, Melinda Triplet
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(14)
Purpose: HSV1716 is an oncolytic herpes simplex virus-1 (HSV-1) studied in adults via injection into the brain and superficial tumors. To determine the safety of administering HSV1716 to pediatric patients with cancer, we conducted a phase I trial of
Autor:
Renee Doughman, Adam Lane, Ute Bartels, Maryam Fouladi, James L. Leach, Christof M. Kramm, Lindsey M. Hoffman, Katherine E. Warren, Joshua J Baugh, David S. Ziegler, Sophie E. M. Veldhuijzen van Zanten, Blaise V. Jones, Jacques Grill, Sharon A. Savage, Lili Miles, Michelle Monje, Cynthia Hawkins, Brooklyn Chaney, Tim Hassall, Dannis G. van Vuurden, Eric Bouffet, Jenavieve Kirkendall, Darren Hargrave, Xiao-Nan Li, Christine Fuller, Alexander J. Towbin, Chris Jones
Publikováno v:
Journal of neuro-oncology. 132(2)
Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched t
Autor:
Maria H. Alonso, Alexander J. Towbin, Jaimie D. Nathan, Greg Tiao, Alexander Bondoc, James I. Geller, Anita Gupta, Amber M. D'Souza
Publikováno v:
Journal of Clinical Oncology. 36:e22505-e22505
e22505Background: Hepatocellular carcinoma (HCC) is an often chemoresistant neoplasm with a poor prognosis. Pediatric HCC may reflect unique biological and clinical heterogeneity. Methods: An IRB a...
Autor:
Hui Sun, Linan Liu, Anke Busch, Leslie G. Biesecker, Shreshtha Madaan, Vincent Huang, Taosheng Huang, Jennifer J. Johnston, Adolfo Sequeira, Sandra Donkervoort, Riki Kawaguchi, Bassem M. Shoucri, Hamidreza Riazifar, Virginia Kimonis, Taraneh Esmailpour, Marquis P. Vawter, Guoli Sun, Alexander J. Towbin, Robert B Chadwick, Jie Wu
Publikováno v:
Journal of medical genetics. 51(3)
Introduction Lenz microphthalmia syndrome (LMS) is a genetically heterogeneous X-linked disorder characterised by microphthalmia/anophthalmia, skeletal abnormalities, genitourinary malformations, and anomalies of the digits, ears, and teeth. Intellec