Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jiaxin Niu"'
Autor:
Adel Samson, Victoria Roulstone, Andrea Pirzkall, Robert M. Conry, Ari M. Vanderwalde, Anna C. Pavlick, Joseph J. Sacco, Jiaxin Niu, Joan Kyula, Robert S. Coffin, Lavita Menezes, Mohammed M. Milhem, Douglas E Laux, Terence Duane Rhodes, Selda Samakoglu, Pablo Nenclares, Scott Baum, Brendan D. Curti, Suzanne Thomas, Tawnya L. Bowles, Jason Chesney, Alex Deterding, Francesca Aroldi, Anna Olsson-Brown, Kevin J. Harrington, Praveen K. Bommareddy, Mark R. Middleton
Publikováno v:
Cancer Research. 81:LB180-LB180
Introduction:RP1 and RP2 are novel, enhanced potency oncolytic versions of HSV1 engineered to express human GM-CSF and the gibbon ape leukemia virus membrane R- glycoprotein (GALV-GP R-), providing constitutive fusion activity and increased immunogen
Autor:
Huan J. Zhu, Howard E. Kaufman, Haifang Jiang, Xusha Zhou, Andrew Haydon, Ganessan Kichenadasse, John M. Kirkwood, Elizabeth I. Buchbinder, Huinan Xu, Minal A. Barve, Jiaxin Niu, Dongyao Ni, Vinod Ganju
Publikováno v:
Journal of Clinical Oncology. 39:2526-2526
2526 Background: T3011 is a genetically modified, next-generation oncolytic HSV-1 with 2 exogenous genes encoding the active heterodimer human interleukin 12 (IL-12) and the Fab fragment of an anti-human PD-1 antibody. Locally produced IL-12 induces
Autor:
Joseph Elassal, Anna C. Pavlick, Adel Samson, Kevin J. Harrington, Jiaxin Niu, Francesca Aroldi, Robert S. Coffin, Alex Deterding, Scott Baum, Tawnya L. Bowles, Brendan D. Curti, Douglas Earl Laux, Mohammed M. Milhem, Joseph J. Sacco, Anna Olsson-Brown, Jason Chesney, Praveen K. Bommareddy, Mark R. Middleton, Ari M. Vanderwalde, Terence Duane Rhodes
Publikováno v:
Journal of Clinical Oncology. 38:e22050-e22050
e22050 Background: RP1 is an oncolytic HSV that encodes a fusogenic GALV-GP R- protein and GM-CSF. RP1 demonstrated tolerable safety and tumor regression alone and with nivolumab (nivo) in ph 1 in patients (pts) with a number of tumor types. To furth