Zobrazeno 1 - 10
of 38
pro vyhledávání: '"David F. Claxton"'
Autor:
Charyguly Annageldiyev, Nicole R. Keasey, Emily Sullivan, Paul T. Toran, Hong Gang Wang, Regina M. Ondrasik, Su Fern Tan, Andrea L. Cote, Tye G. Deering, Todd E. Fox, David J. Feith, Brian M. Barth, Timothy J Brown, Stephan T. Stern, Mark Kester, David F. Claxton, Thomas P. Loughran, Vasiliki Papakotsi, Arati Sharma, Ross L. Levine, David B. Needle, Junjia Zhu, Sriram S. Shanmugavelandy, Aaron D. Viny, Viola Devine, Weiyuan Wang, Jason Liao
Publikováno v:
Blood Advances. 3:2598-2603
Key Points Distinct sphingolipid metabolism of AML with MDS-related changes defines unique sensitivity to nanoliposomal C6-ceramide. Vinblastine alters sphingolipid metabolism to enhance the sensitivity of AML to nanoliposomal C6-ceramide.
Autor:
Pau Montesinos, Farhad Ravandi, Martha Arellano, Karen Seiter, Ellin Berman, Jessica K. Altman, Lori J. Maness, Donald P. Quick, Parameswaran Venugopal, Judy H. Chiao, Scott R. Solomon, Rakesh Gaur, Mikkael A. Sekeres, Maria R. Baer, Marc Buyse, Aleksandra Butrym, David A. Rizzieri, Stephen A. Strickland, Stuart L. Goldberg, Tapan M. Kadia, Marc Gautier, David F. Claxton, Gary J. Schiller, Gianluca Gaidano, Kebede H. Begna, Selina M. Luger, Hagop M. Kantarjian, Xavier Thomas
Publikováno v:
Cancer
CANCER
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Cancer, vol 127, iss 23
CANCER
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Cancer, vol 127, iss 23
BackgroundAcute myeloid leukemia (AML) is fatal in elderly patients who are unfit for standard induction chemotherapy. The objective of this study was to evaluate the survival benefit of administering sapacitabine, an oral nucleoside analogue, in alt
Autor:
Suming Huang, Dhimant Desai, Cesar Aliaga, Pavan Kumar Dhanyamraju, Sadie Steffens, Melanie A. Ehudin, Morgann Klink, Yali Ding, Mohammad Atiqur Rahman, Chunhua Song, Preeti Bhadauria, Arati Sharma, Chandrika Gowda, David F. Claxton, Soumya Iyer
Publikováno v:
Cancers
Volume 13
Issue 5
Cancers, Vol 13, Iss 1127, p 1127 (2021)
Volume 13
Issue 5
Cancers, Vol 13, Iss 1127, p 1127 (2021)
Simple Summary Acute Myeloid Leukemia is an aggressive disease with poor outcomes. New targeted therapies that can boost the effects of currently used chemotherapy medications without added toxicity are needed. Targeting an overactive kinase, called
Autor:
Dhimant Desai, Mark R. Conaway, Thomas P. Loughran, Hong Gang Wang, Samy A.F. Morad, Kenichiro Doi, Xin Liu, David J. Feith, Todd E. Fox, Su Fern Tan, Mark Kester, Myles C. Cabot, David F. Claxton, Wendy Dunton, Shantu Amin
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1078-1086 (2019)
J Lipid Res
J Lipid Res
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission c
Autor:
Amit Verma, Selina M. Luger, Zhuoxin Sun, Puneet S. Cheema, Jaroslaw P. Maciejewski, Martin S. Tallman, Mark R. Litzow, David F. Claxton, Jessica K. Altman, Rami S. Komrokji, John M. Bennett, Alan F. List, Kathy L. McGraw, Ryan J. Mattison, Charles A. Schiffer, Andrew S. Artz, Timothy R. Wassenaar
Publikováno v:
J Clin Oncol
PURPOSE Impaired response to erythropoietin underlies ineffective erythropoiesis and anemia in myelodysplastic syndromes (MDS). We investigated whether treatment with lenalidomide (LEN), which augments erythropoietin receptor signaling in vitro, can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b527e937e93c76976bde4e0ca2a12342
https://europepmc.org/articles/PMC8274743/
https://europepmc.org/articles/PMC8274743/
Autor:
Pinyi Lu, Longgui Chen, Barbara A. Miller, Zhongming Zhao, Charyguly Annageldiyev, Melat T. Gebru, Christopher M. Dower, Jennifer M. Atkinson, Arati Sharma, Megan M. Young, Zhenyuan Tang, Hong Gang Wang, Lijun Zhang, David F. Claxton, Yuka Imamura Kawasawa, Zhenqiu Liu
Publikováno v:
Blood
FLT3 is a frequently mutated gene that is highly associated with a poor prognosis in acute myeloid leukemia (AML). Despite initially responding to FLT3 inhibitors, most patients eventually relapse with drug resistance. The mechanism by which resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a15350f4c228b28961190773dd4afe
https://europepmc.org/articles/PMC7453151/
https://europepmc.org/articles/PMC7453151/
Autor:
Amriti R. Lulla, Jeffrey J. Pu, Jawad Babar, Nadia Khan, Cyril H. Benes, Lanlan Zhou, Joshua E. Allen, A. Pieter J. van den Heuvel, Ultan McDermott, Mala K. Talekar, Mathew J. Garnett, C. Leah B. Kline, Junior Hall, Wolfgang Oster, David F. Claxton, Varun V. Prabhu, David T. Dicker, Wafik S. El-Deiry, Stephan A. Grupp
Publikováno v:
Cell Cycle. 17:468-478
ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent and combinatorial efficacy of ONC201 in preclinical models of hematological malignancies. ON
Autor:
Miki Kassai, Samy A.F. Morad, Li-Pin Kao, Traci S. Davis, Noha Abdelmageed, Gemma Fabriàs, Thomas P. Loughran, José L. Abad, Sarah Spiegel, Su Fern Tan, David J. Feith, Todd E. Fox, Mark Kester, Kelsey H. Fisher-Wellman, Matthew R. MacDougall, Myles C. Cabot, David F. Claxton
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 60, Iss 9, Pp 1590-1602 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Lipid Research, Vol 60, Iss 9, Pp 1590-1602 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4532efe4cdccaac86289135ec63a5056
http://hdl.handle.net/10261/189423
http://hdl.handle.net/10261/189423
Autor:
Priyanjali Bhattacharya, Su Fern Tan, Trupti Patel, Sinisa Dovat, Dhimant Desai, David F. Claxton, Thomas P. Loughran, Charyguly Annageldiyev, Shantu Amin, David J. Feith, Soumya Iyer, Krishne Gowda, Arati Sharma
Publikováno v:
Haematologica
Leukemic stem cells are multipotent, self-renewing, highly proliferative cells that can withstand drug treatments. Although currently available treatments potentially destroy blast cells, they fail to eradicate leukemic progenitor cells completely. A
Autor:
Thomas P. Loughran, Brian M. Barth, Mark Kester, Matthew R. MacDougall, Su-Fern Tan, Tonya N. Zeczycki, Todd E. Fox, Myles C. Cabot, David F. Claxton, P. Darrell Neufer, Traci S. Davis, Terence E. Ryan, David J. Feith, Tye G. Deering, Samy A.F. Morad
Publikováno v:
Journal of Lipid Research. 57:1231-1242
The objective of our study was to determine the mechanism of action of the short-chain ceramide analog, C6-ceramide, and the breast cancer drug, tamoxifen, which we show coactively depress viability and induce apoptosis in human acute myelogenous leu