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Publikováno v:
International Journal of Oral and Maxillofacial Surgery. 51:713-723
Melatonin receptors can inhibit breast and prostate cancers; however, little is known regarding their effects on oral squamous cell carcinoma. In this study, we collected specimens from 81 patients with oral squamous cell carcinoma and analysed clini
Autor:
Bárbara Arévalo, Verónica García-Castillo, Carlos Pérez-Plasencia, Margarita Gutiérrez, Rebeca Salgado-García, Nelson E. Brown, Alexandra Olate-Briones, Francisco Valdes, Claudio Valenzuela, Angel Cayo
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1414-1425
Background: Adenosine is a natural nucleoside present in a variety of organs and tissues, where it acts as a modulator of diverse physiological and pathophysiological processes. These actions are mediated by at least four G protein-coupled receptors,
Autor:
Parthiban Marimuthu, Thirugnanasambandham Sivasubramanian Anitha, Mugilarasi Purushothaman, Muralidharan A Ramachandran, Daisy S. Precilla, Shreyas S Kuduvalli
Publikováno v:
Current Molecular Pharmacology. 15:338-360
Background: Glioblastoma Multiforme (GBM) is one of the most heterogeneous primary brain tumors with high mortality. In spite of the current therapeutic approaches, the survival rate remains poor, with death occurring within 12 to 15 months after the
Autor:
Emily Kessler, Rodrigo Saad-Berreta, Hongwu Zheng, Vikram Deshpande, Krishna S. Tummala, Brandon Nicolay, William Shen, Ramzi Adil, Meng-Ju Wu, Juan Dubrot, Lipika Goyal, Vajira Weeresekara, Amaya Pankaj, Mathias Heikenwalder, Tong Wang, Mirian Fernandez-Vaquero, María García-Beccaria, Ting-Yu Wei, Kira E Olander, Sebastien Ronseaux, Vindhya Vijay, Qibiao Wu, Yuanli Zhen, Christine Hudson, Nabeel Bardeesy, Lei Shi, Rahul M. Kohli, Meiqi Luo, Yi Sun, Russell W. Jenkins, Robert T. Manguso, Cristina R. Ferrone, Joshua Merritt
Publikováno v:
Cancer Discovery. 12:812-835
Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma. (R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits multiple α-ketoglutarate–dependent enzymes, altering epigenetics and metabolism. Here, by developing mIDH1
Autor:
Sunil J. Advani, Hyunho Yoon, Rowan Ustoy, Mayra Yebra, Vipul R. Sheth, Sudeep Banerjee, Michael Heinrich, Christian M. Metallo, Joseph A. Aguilera, Sangkyu Noh, Scott M. Lippman, Razelle Kurzrock, Chih-Min Tang, Olivier Harismendy, Paul T. Fanta, Adam M. Burgoyne, Avi Kumar, Thekla Cordes, Shruti Bhargava, Sam Li, Jason K. Sicklick, Christopher L. Corless
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 1
Purpose: Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract, with mutant succinate dehydrogenase (SDH) subunits (A–D) comprising less than 7.5% (i.e., 150–200/year) of new cases annually in the United S
Autor:
Lei Liang, Qing-Qing Zhou, Xiang Luo, Hai-Biao Gong, Hiroshi Kurihara, Jiaxu Chen, Rong-Rong He, Yi-Fang Li, Tongzheng Liu, Hua-Ying Gao, Yan-Ping Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 197-209 (2022)
The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies; however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis cont
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 56-64 (2022)
Acute kidney injury (AKI) is a serious complication in critically ill patients. Accumulating evidences indicated that macrophages play an important pro-inflammatory role in AKI and isoliquiritigenin (ISL) can inhibit macrophagic inflammation, but its
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 221-230 (2022)
FEBS Open Bio
FEBS Open Bio
DDB1 and CUL4 associated factor 13 (DCAF13) is a substrate receptor in the CUL4‐DDB1 E3 ligase, and its expression is associated with the prognosis of certain cancers. In the present study, we report evidence that DCAF13 is aberrantly overexpressed
Autor:
Qian Mao, Wenjing Zhang, Yujie Liu, Yanfeng Ren, Juncheng Lyu, Qinghua Wang, Fuyan Shi, Yuting Li, Suzhen Wang
Publikováno v:
Aging. 13:24271-24289
Recent studies have demonstrated the role of Nod-like receptor protein 3 (NLRP3) inflammasome in promoting melanoma progression. Immune checkpoint inhibitors (ICI) treatment dramatically extended the survival outcomes for advanced melanoma patients.
Autor:
Chiara Mazziotta, Fernanda Martini, John Charles Rotondo, Giulia Campione, Carmen Lanzillotti, Mauro Tognon
Publikováno v:
Oncogene
A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to be overexpressed in a large number of cancer types. This receptor plays an important role in cancer by interacting with adenosine. Specifically, A3AR has a dual nature i