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Publikováno v:
Molecular Cancer Therapeutics. 20:2519-2526
Immune-related pneumonitis is an important toxicity associated with checkpoint inhibitor therapy with anti–PD-1 or anti–PD-L1 antibodies, often necessitating discontinuation of treatment. Development of methods to mitigate checkpoint inhibitor–
Autor:
Rodney P. Rocconi, Seema Singh, Kunwar Somesh Vikramdeo, Mohammad Aslam Khan, Santanu Dasgupta, Sarabjeet Kour Sudan, Annelise M. Wilhite, Ajay P. Singh
Publikováno v:
Semin Cancer Biol
Resistance to platinum-based chemotherapy is a major clinical challenge in ovarian cancer, contributing to the high mortality-to-incidence ratio. Management of the platinum-resistant disease has been difficult due to diverse underlying molecular mech
Autor:
Sushmita Pathy, Akash Kumar, Gaurav Gupta, Sandeep Bhoriwal, Satyajit Pawar, Sujoy Pal, Rajesh Kumar, Sanjay Thulkar, Sunil Kumar, Priyanshu Choudhary, Nihar Ranjan Dash, Atul Sharma, Raja Pramanik
Publikováno v:
JCO Global Oncology
PURPOSE For unresectable gallbladder cancer (GBC), gemcitabine and platinum is standard combination; however, outcome is poor. We conducted this study to find feasibility of modified flourouracil, oxaliplatin, and irinotecan in this group. MATERIALS
Autor:
Xiawei Wei, An Tong, Yang Yang, Ruyu Pi, Xia Zhao, Tianqi Lu, Xiaoyi Hu, Houhui Shi, Hongyi Li, Yuquan Wei, Xi Wang, Yu Liu
Publikováno v:
Cancer Letters. 523:72-81
Mechanistic target of rapamycin (mTOR) forms two distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. Here we investigated the antitumor effect of dual mTORC1/2 inhibitor AZD2014 on epithelial ovarian cancer (EOC) and its potential effect on immun
Autor:
Weili Qi, Chuan Li, Wei Peng, Junlong Dai, Shun Ran, Junyi Shen, Yu Zhang, Shusheng Leng, Tian-Fu Wen, Youwei Wu, Xiaoyun Zhang, Fengwei Gao
Publikováno v:
Cancer Medicine, Vol 10, Iss 23, Pp 8421-8431 (2021)
Cancer Medicine
Cancer Medicine
Background Antiviral therapy should reduce the recurrence of hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) after surgical resection. However, there is little research on whether various antiviral drugs have different progno
Autor:
Philipp B. Staber, Peter Bettelheim, Christian Sillaber, Gabriele Stefanzl, Dubravka Smiljkovic, Daniela Berger, Georg Greiner, Peter Valent, Karin Bauer, Wolfgang R. Sperr, Ana-Iris Schiefer, Susanne Gamperl, Ilse Schwarzinger, Renate Thalhammer, Gregor Hoermann, Paul Knöbl, Christoph Kornauth
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1183-1191 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
During progression of myeloid neoplasms, the basophil compartment may expand substantially and in some of these patients, a basophilic leukemia is diagnosed. In patients with Ph-chromosome+ chronic myeloid leukemia, acceleration of disease is typical
Transglutaminase 2 Maintains Hepatocyte Growth Factor Signaling to Enhance the Cancer Cell Phenotype
Autor:
Warren Naselsky, Wen Xu, Xi Chen, Suruchi Shrestha, Gautam Adhikary, Jeffrey W. Keillor, Richard L. Eckert
Publikováno v:
Mol Cancer Res
Transglutaminase 2 (TG2) is a key epidermal squamous cell carcinoma cancer cell survival protein. However, how TG2 maintains the aggressive cancer phenotype is not well understood. The present studies show that TG2, which is highly expressed in epide
Publikováno v:
Bioengineered, Vol 12, Iss 2, Pp 11154-11166 (2021)
Bioengineered
article-version (VoR) Version of Record
Bioengineered
article-version (VoR) Version of Record
Venous thromboembolism (VTE) is the third most prevalent cardiovascular complication. Increasing studies have demonstrated that some microRNAs (miRNAs) are aberrantly expressed in VTE and play crucial roles in mediating the development of VTE. Theref
Autor:
Yoshiaki Murakami, Shingo Seo, Hiroyuki Otsuka, Yasushi Hashimoto, Naru Kondo, Shinya Takahashi, Takeshi Sudo, Kenjiro Okada, Tatsuaki Sumiyoshi, Kenichiro Uemura
Publikováno v:
European Journal of Cancer. 159:215-223
Background The prognosis of patients with borderline resectable pancreatic cancer with arterial contact (BRPC-A) is extremely poor, and effective preoperative treatment is indispensable. We evaluated the clinical efficacy and safety of neoadjuvant ch
Autor:
Jinping Gao, Gang Chen, Yujun Sheng, Xing Fan, Ze Guo, Liangdan Sun, He Huang, Xianfa Tang, Hui Cheng, Huayang Tang, Xiaodong Zheng, Wenjun Wang
Publikováno v:
Immunology Letters. 240:98-105
Psoriasis is an immune-mediated genetic disease involving innate and the adaptive immune system. Aurora kinase A (AURKA) belongs to a seine/threonine kinases family and is elevated in lesional psoriatic tissues. This research aimed to investigate the