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Publikováno v:
J Biomol Struct Dyn
Modulation of proteasome function by pharmacological interventions and molecular biology tools is an active area of research in cancer biology and neurodegenerative diseases. Curcumin (diferuloylmethane) is a naturally occurring polyphenol that affec
Publikováno v:
Cannabis and cannabinoid research. 7(5)
Background: Endogenous and synthetic cannabinoids have been shown to induce cancer cell death through the accumulation of the sphingolipid, ceramide (Cer). Recently, we have demonstrated that Cer accumulation enhances the induction of immunogenic cel
Publikováno v:
Seminars in Cancer Biology. 85:234-245
Accumulating evidence has demonstrated that cancer stem cells (CSCs) play an essential role in tumor progression and reoccurrence and drug resistance. Multiple signaling pathways have been revealed to be critically participated in CSC development and
Publikováno v:
Journal of Pharmaceutical Analysis. 12:394-405
Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for various biological cell functions. NF-κB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in cells. N
Publikováno v:
Calcified Tissue International. 111:211-223
Aseptic loosening of the prosthesis caused by wear-particle-induced osteolysis is a long-term complication and one of the most common reasons for the failure of joint implants. The primary cause of aseptic loosening of the prosthesis is overactive bo
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1742-1752
Background: Dehydrocostus lactone (DEH), one of the sesquiterpene lactones, has shown extensive pharmaceutical activities, including anti-cancer activity. However, its effects on human esophageal squamous cell carcinoma (ESCC) cells are still unknown
Autor:
Min Gyu Woo, Yong Sung Kim, Mi Kwon Son, Seung-Min Shin, Zhenghuan Fang, Kyung Hee Jung, Soon-Sun Hong, Young-Chan Yoon, Hong Hua Yan, Ji Eun Lee, Yeo Wool Kang, Jung Hee Park
Publikováno v:
Biomolecules & Therapeutics. 30:274-283
KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Therefore, combined targeting
Publikováno v:
Tissue Engineering Part A. 28:330-340
Glioblastoma (GBM) displays diffusive invasion throughout the brain microenvironment that is partially responsible for its short median survival rate (
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 10, Iss, Pp 335-344 (2022)
Bioactive Materials, Vol 10, Iss, Pp 335-344 (2022)
Osteoporosis is a reduction in skeletal mass due to the decrease of osteogenic ability and the activation of the osteoclastic function. Inhibiting bone resorption and accelerating the new bone formation is a promising strategy to repair the bone defe
Autor:
Kazuki Taoka, Ken Sasaki, Yosuke Masamoto, Mineo Kurokawa, Masashi Miyauchi, Shunya Arai, Sho Yamazaki, Hideaki Mizuno, Yuki Kagoya
Publikováno v:
Blood Advances. 6:1585-1597
Although JAK1/2 inhibition is effective in alleviating symptoms of myelofibrosis (MF), it does not result in the eradication of MF clones, which can lead to inhibitor-resistant clones emerging during the treatment. Here, we established induced plurip