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Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 38:122-131
Background: Gastric cancer (GC) is a common tumor found worldwide, and cisplatin is the first-line agent for the treatment of GC. However, the resistance to cisplatin is an obstacle. Here, we aim to explore the biological mechanism of long noncoding
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 37:708-719
Background: Circular RNAs (circRNAs) have important roles in human malignancies, including breast cancer (BC). In this study, we intended to explore the function of circRNA ribonuclease P RNA component H1 (circ_RPPH1) in BC development and clarify th
Autor:
Zhenkun Lou, Jake A. Kloeber
Publikováno v:
Seminars in Cancer Biology. 85:164-184
The acquisition of DNA damage is an early driving event in tumorigenesis. Premalignant lesions show activated DNA damage responses and inactivation of DNA damage checkpoints promotes malignant transformation. However, DNA damage is also a targetable
Autor:
Tzu-Jung Yu, Sheng-Chieh Wang, Pei-Feng Liu, Hans-Uwe Dahms, Jen-Yang Tang, Hsueh-Wei Chang, Cheng-Hsin Lee, Ammad Ahmad Farooqi, Sheng-Yao Peng, Chih-Wen Shu
Publikováno v:
Seminars in Cancer Biology. 83:269-282
Noncoding RNAs (ncRNAs) regulation of various diseases including cancer has been extensively studied. Reactive oxidative species (ROS) elevated by oxidative stress are associated with cancer progression and drug resistance, while autophagy serves as
Autor:
Lei Liu, Jia Wu, Minxin Shi, Fengying Wang, Haimin Lu, Jibing Liu, Weiqin Chen, Guanzhen Yu, Dan Liu, Jing Yang, Qin Luo, Yan Ni, Xing Jin, Xiaoxia Jin, Wen-Lian Chen
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:670-687
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with a poor prognosis. Although several serum metabolomic investigations have been reported, ESCC tumor-associated metabolic alterations and predictive bio
Autor:
Kelly J. Yu, Michael Dean, Cyllene R. Morris, Brenda Y. Hernandez, Ajay K. Israni, Iona Cheng, Thomas C. Tucker, Petra Lenz, Shehnaz K. Hussain, David Peterson, Charles F. Lynch, Yelena G. Golubeva, Gabriel J. Starrett, Lou Gonsalves, Mary L Piaskowski, Christopher B. Buck, Ludmila Prokunina-Olsson, Eric A. Engels, Reuben S. Harris, Paul S. Meltzer
Publikováno v:
eLife. 12
A small percentage of bladder cancers in the general population have been found to harbor DNA viruses. In contrast, up to 25% of tumors of solid organ transplant recipients, who are at an increased risk of developing bladder cancer and have overall p
Autor:
Min Gyu Woo, Yong Sung Kim, Mi Kwon Son, Seung-Min Shin, Zhenghuan Fang, Kyung Hee Jung, Soon-Sun Hong, Young-Chan Yoon, Hong Hua Yan, Ji Eun Lee, Yeo Wool Kang, Jung Hee Park
Publikováno v:
Biomolecules & Therapeutics. 30:274-283
KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Therefore, combined targeting
Publikováno v:
Chinese Chemical Letters. 33:2213-2230
Chemodynamic therapy (CDT), defined as an in situ oxidative stress response catalyzed by the Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals (•OH) at tumor sites, exhibits conspicuous inhibition of tumor growth. It has attra
Autor:
Tie Changjun, Hairong Zheng, Yang Deng, Mian Yu, Weiwei Zeng, Qianqian Li, Chen Ting, Hao Huisong, Lin Mei, Meiying Wu
Publikováno v:
Bioactive Materials, Vol 10, Iss, Pp 515-525 (2022)
Bioactive Materials
Bioactive Materials
The imbalance between oxidants and antioxidants in cancer cells would evoke oxidative stress-induced cell death, which has been demonstrated to be highly effective in treating malignant tumors. Sonodynamic therapy (SDT) adopts ultrasound (US) as the
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1080-1090
Background: Macrophage migration inhibitory factor (MIF), originally reported as an inflammation regulating molecule, is elevated in various cancer cells, which may promote carcinogenesis. Meanwhile, ISO-1 is a potent small molecular inhibitor of MIF