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Autor:
Lorinda Simms, Shehkar Patil, David R. Gandara, Anders Mellemgaard, Raghunadharao Digumarti, Bonne Biesma, Johan Vansteenkiste, Mauro Zukin, Joachim von Pawel, Katherine P. Sugarman, Keunchil Park, Christian Manegold, Filippo de Marinis, Tuncay Göksel, Janusz Rolski, Piotr Serwatowski, Jin S. Lee, Giorgio V. Scagliotti, Ulrich Gatzemeier, Purvish M. Parikh
Publikováno v:
Journal of Clinical Oncology. 41:2458-2466
PURPOSE Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non–small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting. PATIENTS AND METHODS
Autor:
David H. Johnson, Roy S. Herbst, Corey J. Langer, Louis Fehrenbacher, William Novotny, Eric Holmgren, Jacques Gaudreault, John Nemunaitis, David M. Jablons, Fairooz F. Kabbinavar, Russell F. DeVore, Lisa A. Damico
Publikováno v:
Journal of Clinical Oncology. 41:2305-2312
Purpose To investigate the efficacy and safety of bevacizumab plus carboplatin and paclitaxel in patients with advanced or recurrent non-small-cell lung cancer. Patients and Methods In a phase II trial, 99 patients were randomly assigned to bevacizum
Autor:
Foteinos-Ioannis Dimitrakopoulos, Kyriaki Papadopoulou, Dimitrios Pectasides, Anna Batistatou, Kitty Pavlakis, George Fountzilas, Helen P. Kourea, Sofia Chrisafi, George Pentheroudakis, Vassiliki Kotoula, Pavlos Papakostas, Eleni Galani, Eleni Res, Dimitrios Bafaloukos, Angelos Koutras, Georgia-Angeliki Koliou, Mattheos Bobos, Kyriakos Chatzopoulos, Anthoula Asimaki-Vlachopoulou
Publikováno v:
Cancer Research and Treatment. 54:1053-1064
Purpose Angiogenesis is a crucial phenomenon in the development and progression of breast cancer (BC), but the clinical significance of angiogenesis-related proteins in metastatic BC remains unknown. This study investigates the prognostic value of va
Autor:
Diana Xochiquetzal Robledo-Cadena, Marco Antonio García-Amezcua, Javier Alejandro Belmont-Díaz, Rafael Moreno-Sánchez, Alhelí Adán-Ladrón de Guevara, Silvia Cecilia Pacheco-Velázquez, Juan Carlos Gallardo-Pérez, Sara Rodríguez-Enríquez, Jorge Luis Vargas-Navarro
Publikováno v:
Current Medicinal Chemistry. 29:2719-2735
Background: The major hurdles for successful cancer treatment are drug resistance and invasiveness developed by breast cancer stem cells (BCSC). Objective: As these two processes are highly energy-dependent, the identification of the main ATP supplie
Autor:
Qin Zhou, Xiaohua Liu, Cuiling Qi, Jinlian Li, Lijing Wang, Qianqian Zhang, Lingyun Zheng, Jinghua Cao, Shuting Zheng, Guanquan Mao
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1735-1741
Background: Breast cancer is one of the most common cancers worldwide among women, and angiogenesis has an important effect on its growth and metastasis. Glipizide, which is a widely used drug for type 2 diabetes mellitus, has been reported to inhibi
Publikováno v:
Medicinal Chemistry. 18:589-601
Background: Breast cancer is the leading cause of cancer death in women. The current methods of chemotherapy for breast cancer generally have strong adverse reactions and drug resistance. Therefore, the discovery of novel anti-breast cancer lead comp
Autor:
Afnan K. AlHiary, Lina A. Dahabiyeh, Anas M. Abdel Rahman, James W. Dennis, Judy Pawling, Dana D. Shalabi, Bushra M. Akileh, Sanaa K. Bardaweel
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1611-1621
Background: Chronic inflammation plays a crucial role in the initiation, promotion, and invasion of tumors, and thus the antiproliferative effects of numerous anti-inflammatory drugs have been frequently reported in the literature. Upregulation of th
Publikováno v:
Journal of Microencapsulation. 39:197-209
Folic acid was coupled to melphalan using glycyl-glycine (FA-Gly-Gly-Melphalan) to synthesise self-assembled nanomicelles for targeting ovarian cancer cells, SKOV3.FA-Gly-Gly-Melphalan self-assembled nanomicelles were prepared with critical micellar
Autor:
Atif Abdulwahab A. Oyouni, Syed Khalid Mustafa, Lamjed Mansour, Ibrahim Barnawi, Yousef M Hawsawi, Nahed A Hussien, Suliman Y Alomar, Osama Al-Amer, Philip R. Dash
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1397-1406
Background: Despite the advancement in the fields of medical science and molecular biology, cancer is still the leading cause of death worldwide. Chemotherapy is a choice for treatment; however, the acquisition of chemoresistance is a major impedimen
Autor:
Daniel Moj, Nicola Ammer, Babette Aicher, Jan-Georg Wojtyniak, Thorsten Lehr, Michael Teifel, Herbert Sindermann, Hannah Britz, Nina Hanke
Zoptarelin doxorubicin is a fusion molecule of the chemotherapeutic doxorubicin and a luteinizing hormone-releasing hormone receptor (LHRHR) agonist, designed for drug targeting to LHRHR positive tumors. The aim of this study was to establish a physi
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c5e9a18956370d7aca5ee1061fd910