Zobrazeno 1 - 10
of 1 404
pro vyhledávání: ''
Autor:
Jia-hao Bao, Jiang-bo Li, Han-sen Lin, Wen-jin Zhang, Bing-yan Guo, Jun-jie Li, Liang-min Fu, Yang-peng Sun
Publikováno v:
Analytical Cellular Pathology. 2022:1-27
Clear cell renal cell carcinoma (ccRCC) is the most common histological and devastating subtype of renal cell carcinoma. Necroptosis is a form of programmed cell death that causes prominent inflammatory responses. miRNAs play a significant role in ca
Autor:
Hongseok Yun, Seung Hong Choi, Ka Young Lim, Seung-Ki Kim, Yumi Shim, Tae Min Kim, Jin-Woo Park, Hyunhee Kim, Jeongwan Kang, Sung Hye Park, Chul-Kee Park, Kwanghoon Lee, Jae Kyung Won
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Mismatch repair-deficient (MMRD) brain tumors are rare among primary brain tumors and can be induced by germline or sporadic mutations. Here, we report 13 MMRD-associated (9 sporadic and 4 Lynch syndrome) primary brain tumors to determine clinicopath
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Gliomas are the most common and recalcitrant intracranial tumors, approximately a quarter of which are classified as lower-grade gliomas (WHO II–III). Although the prognosis of lower-grade gliomas (LGGs) is significantly better than that of higher-
Publikováno v:
Laboratory Investigation. 102:38-47
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide. Dysregulation of circular RNAs (circRNAs) appears to be a critical factor in CRC progression. However, mechanistic studies delineating the role of circRNAs in CRC r
Autor:
Lin Tan, Weiming Qu, Dajun Wu, Minji Liu, Qian Wang, Qiongjia Ai, Hongsai Hu, Min Chen, Weishun Chen, Hongbing Zhou
Publikováno v:
Analytical Cellular Pathology, Vol 2021 (2021)
Analytical Cellular Pathology (Amsterdam)
Analytical Cellular Pathology (Amsterdam)
GRHL3 is a factor associated with a tumor, of which the molecular mechanism remains a further investigation. We explored the underlying mechanism of tumor-promoting effect of GRHL3 in colorectal cancer (CRC), which is involved in the MEK1/2 pathway.
Autor:
Fatemeh Taheri, Soheila Fattahi, Mahdi Ghatrehsamani, Maryam Anjomshoa, Faramarz Mohammad Alibeigi, Nader Bagheri, Hedayatollah Shirzad, Monireh Karimi
Publikováno v:
Int J Exp Pathol
Bladder cancer (BC) is one of the most prevalent cancers around the world and, if not treated well, has high morbidity and mortality. Many studies have indicated that there may be various roles for the aryl hydrocarbon receptor (AHR) in the immune sy
Autor:
Ryusuke Muroya, Mayuko Inoue, Jing Gao, Yudai Tajiri, Koji Okabe, Masashi Shin, Fei Huang, Ryoko Nagano, Kazuhiro Aoki, Takayoshi Yamaza, Yukihiko Tamura, Shinsuke Fujii, Tamotsu Kiyoshima, Miho Matsuda, Toshio Kukita, Kengo Nagata, Eijiro Jimi, Yoshihide Mori, Sakura Chishaki
Publikováno v:
Laboratory Investigation. 101:1475-1483
Oral malignant melanoma, which frequently invades the hard palate or maxillary bone, is extremely rare and has a poor prognosis. Bone morphogenetic protein (BMP) is abundantly expressed in bone matrix and is highly expressed in malignant melanoma, in
Autor:
Adrian Tira, Lela Buckingham
Publikováno v:
Int J Exp Pathol
Glioblastoma (GBM) is a highly malignant primary brain tumour displaying rapid cell proliferation and infiltration. GBM primarily occurs at older age; however, younger populations have also been affected. In GBM and other cancers, genetic and epigene
Autor:
Aurelie Pac-Soo, Lin Chen, Daqing Ma, Hailin Zhao, Qian Chen, Shanglong Yao, You Shang, Azeem Alam
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Epithelial–mesenchymal transition (EMT) plays a crucial role in the development of pulmonary fibrosis. This study aims to investigate the effects of valproic acid (VPA) on EMT in vitro and in vivo. In vitro, EMT was induced by the administration of
Autor:
Tadayoshi Okimoto, Takahiro Hiratsuka, Shusaku Kurogi, Masafumi Inomata, Tomohisa Uchida, Daisuke Kakisako, Teijiro Hirashita, Masatsugu Moriyama, Chisato Nakada, Yoshiyuki Tsukamoto, Naoki Hijiya, Yuka Hirashita, Tsuyoshi Etoh, Tomonori Akagi, Masaaki Kodama, Yoshitake Ueda, Kazuhiro Mizukami, Yoko Kudo, Koichi Honda, Kazunari Murakami, Hidefumi Shiroshita
Publikováno v:
Laboratory Investigation. 101:1036-1047
Mutations in RAS or BRAF are associated with poor prognosis and resistance to epidermal growth factor receptor (EGFR)-targeted therapy in colorectal cancer (CRC). Despite their common ability to activate downstream genes such as MEK and ERK, the ther