Zobrazeno 1 - 10
of 7 693
pro vyhledávání: ''
Autor:
Katherine N. MacDonald, Michael G. Hall, Sabine Ivison, Sanjiv Gandhi, Ramon I. Klein Geltink, James M. Piret, Megan K. Levings
Publikováno v:
Cytotherapy. 24:1121-1135
Given the promising results from phase 1/2 clinical trials of therapy involving regulatory T cells (Tregs), it is critical to develop Treg manufacturing methods that use well-defined reagents.Seeking to maximize expansion of human thymic Tregs activa
Autor:
Shiwen Deng, Tong Lei, Hongyu Chen, Huiting Zheng, Zhuangzhuang Xiao, Shanglin Cai, Zhongci Hang, Weini Xiong, Yanqing Yu, Xiaoshuang Zhang, Yanjie Yang, Wangyu Bi, Hongwu Du
Publikováno v:
Cytotherapy. 24:1095-1104
Stem cells from human exfoliated deciduous teeth (SHED) play a significant role in tissue engineering and regenerative medicine. Angiogenesis is crucial in tissue regeneration and a primary target of regenerative medicine. As a first-line anti-diabet
Publikováno v:
Human Cell. 36:1-14
In vitro culture of human limbal epithelial stem cells (hLESCs) is crucial to cell therapy in the treatment of limbal stem cell deficiency, a potentially vision-threatening disease that is characterized by persistent corneal epithelial defects and co
Publikováno v:
Human Cell. 35:1671-1683
Osteoporosis is a disorder characterized by reduced bone mass, disruption of bone microarchitecture, and a propensity to fracture. The osteogenic differentiation of human bone mesenchymal stromal cells (hBMSCs) exerts a critical effect on preventing
Publikováno v:
Human Cell. 35:995-1004
Diabetic nephropathy is one of the most important chronic microvascular complications of diabetes, and its main feature is diabetic glomerulosclerosis. Endothelial sirtuin 1 (SIRT1) expression is related to aging, and reducing SIRT1 expression promot
Autor:
Chao Li, Robert Chunhua Zhao, Yi Fu, Yu Hu, Hongcui Cao, Yi Xu, Dongdong Wang, Wang Yue, Junfen Fan, Wei He, Jianmin Zhang, Hui Chen
Publikováno v:
Cytotherapy. 24:393-404
Background aims Given their low immunogenicity, immunoregulatory effects and multiple differentiation capacity, mesenchymal stromal cells (MSCs) have the potential to be used for “off-the-shelf” cell therapy to treat various diseases. However, th
Autor:
Shantibhusan Senapati, Amlan Priyadarshee Mohapatra, Voddu Suresh, Biswajit Das, Deepti Parida, Aliva Prity Minz, Debasish Mohapatra, Rajeeb K. Swain, Usharani Nayak
Publikováno v:
Laboratory Investigation. 102:298-311
Pancreatic cancer (PC) is highly resistant to chemo and radiotherapy. Radiation-induced fibrosis (RIF) is a major cause of clinical concern for various malignancies, including PC. In this study, we aimed to evaluate the radiosensitizing and anti-RIF
Autor:
Shijie, Chen, Guixia, Shi, Jin, Zeng, Ping Huang, Li, Yi, Peng, Zhiyu, Ding, Hong Qing, Cao, Ruping, Zheng, Weiguo, Wang
Publikováno v:
Human Cell. 35:779-791
Nucleus pulposus (NP) cells play a critical role in maintaining intervertebral disc integrity through producing the components of extracellular matrix (ECM). NP cell dysfunction, including senescence and hyper-apoptosis, has been regarded as critical
Autor:
Danyang Shi, Jinhua Ding, Shouqiang Xie, Lei Huang, Hongmin Zhang, Xiaojie Chen, Xuejun Ren, Sa Zhou, Hongpeng He, Wenjian Ma, Tongcun Zhang, Nan Wang
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Upon vascular injury, vascular smooth muscle cells (VSMCs) change from a contractile phenotype to a synthetic phenotype, thereby leading to atherogenesis and arterial restenosis. Myocardin (MYOCD) is essential for maintaining the contractile phenotyp
Autor:
Jean-Paul Courneya, Rita Fishelevich, Irina G. Luzina, Violeta Rus, Sergei P. Atamas, Brian Hampton, Alexander V. Misharin, Nevins W. Todd, Virginia Lockatell, Tudor C. Badea, Horea Rus
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:146-157
Some previous studies in tissue fibrosis have suggested a profibrotic contribution from elevated expression of a protein termed either Regulator of Cell Cycle (RGCC) or Response Gene to Complement 32 Protein (RGC-32). Our analysis of public gene expr