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Publikováno v:
Aging (Albany NY)
Objective: Long non-coding RNAs (lncRNAs) exert a critical function in mediating neuropathic pain (NP). MEG3, a novel lncRNA, contributes to astrocyte activation and inflammation. However, its role in NP remains unclear. Methods: The chronic constric
Autor:
Jinqi Wang, Haozhen Lv, Xuanhao Zeng, Yating Liu, Qi Zhang, Jinhua Xu, Weiling Lian, Kelu Wei
Publikováno v:
Biochemical and Biophysical Research Communications. 573:151-157
Although surgical interventions have become optional for refractory vitiligo, grafting related injuries is inevitable. Embryonic stem cell (ESC) derivatives can be used in transplantation to address this issue, but the immune rejection due to allogen
Publikováno v:
Journal of Investigative Dermatology. 141:2354-2368
Cutaneous squamous cell carcinomas (SCCs) are frequent heterogeneous tumors arising from sun-exposed regions of the skin and characterized by complex pathogenesis. HOPX is a member of the homeodomain-containing superfamily of proteins holding an atyp
Publikováno v:
Biochemistry and Cell Biology. 99:629-635
The PI3K/AKT pathway plays an important role in the development of osteosarcoma. RNF38 interferes with activation of the AKT pathway. Cryptochrome1 (CRY1) inhibits osteosarcoma proliferation through the AKT pathway. We aimed to clarify whether RNF38
Autor:
Wenbo Li, Xi Wang, Songtao An, Yanyan Qi, Hua Meng, Dongchang Chen, Tingting Zhu, Tingting Zhang
Publikováno v:
Laboratory Investigation. 101:1318-1326
In the myocardial infarction microenvironment, the effect of macrophages on the function of bone marrow mesenchymal stem cells (BMSCs) is unclear. In this study, we investigated the role of hypoxia/serum deprivation (H/SD)-induced M1-type macrophage-
Publikováno v:
Biochemical and Biophysical Research Communications. 573:69-75
Breast cancer (BRCA) is one of the most threatening cancer types, especially among the female population. 70% of breast cancer are estrogen receptor α (ERα) positive and endocrine therapy is effective to decrease breast cancer risk. Autophagy, a hi
Autor:
Hyun-Il Cho, Yunkyung Lee, Tai-Gyu Kim, Gaeun Hur, Hee-Je Kim, Haeyoun Choi, Sang-Eun Lee, Hyun-Jung Sohn, Byung Sik Cho
Publikováno v:
Cytotherapy. 23:908-917
Background aims Immunotherapeutic approaches using γδ T cells have emerged as the function of γδ T cells in tumor surveillance and clearance has been discovered. In vitro expansion methods of γ9δ2 T cells have been based on phosphoantigens and
Autor:
Xiaolong Ma, Kemin Liu, Yang Liu, Cheng Zhao, Yan Yao, Yichen Zhao, Meng Xin, Quan Liu, Yue Ma, Shuyun Bai, Pengfei Chen, Jiangang Wang, Qing Ye, Chen Bai, Caiwu Zeng
Publikováno v:
Journal of Cellular and Molecular Medicine
Alteration of tissue inhibitors of matrix metalloproteinases (TIMP)/matrix metalloproteinases (MMP) associated with collagen upregulation has an important role in sustained atrial fibrillation (AF). The expression of miR‐146b‐5p, whose the target
Autor:
James Ropa, Scott Cooper, Maegan L. Capitano, Samisubbu R. Naidu, Xinxin Huang, Hal E. Broxmeyer
Publikováno v:
Leukemia
Little is known of hematopoietic stem (HSC) and progenitor (HPC) cell self-renewal. The role of Brahma (BRM), a chromatin remodeler, in HSC function is unknown. Bone marrow (BM) from Brm−/− mice manifested increased numbers of long- and short-ter
Publikováno v:
Biochemical and Biophysical Research Communications. 574:20-26
Retinoblastoma is an intraocular malignant tumor and generally occurred in childhood. Here, we intended to appraise the functional influence of microRNA-142-5p (miR-142-5p) in retinoblastoma. MiR-142-5p was declined, and MYCN was upregulated in retin