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Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Autologous fat grafting is often a crucial aspect of reconstructive and aesthetic surgeries, yet poor graft retention is a major issue with this technique. Enriching fat grafts with adipose tissue-derived mesenchymal stem cells (AD-MSCs) i
Autor:
Nobuhide Higashino, Mari Nishio, Masaki Shimizu, Yoshihiro Kakeji, Masataka Fujikawa, Takayuki Kodama, Hiroki Sakamoto, Hiroshi Yokozaki, Kohei Tanigawa, Manabu Shigeoka, Yu-ichiro Koma
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Cancer-associated fibroblasts (CAFs) contribute to the progression of various cancers. Previously, we reported the significance of CAFs in esophageal squamous cell carcinoma (ESCC); however, the functions of CAFs in the ESCC microenvironment remain u
Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human
Autor:
Ellen V. Rothenberg
Publikováno v:
Exp Hematol
T-Cell development is a major branch of lymphoid development and a key output of hematopoiesis, especially in early life, but the molecular requirements for T-cell potential have remained obscure. Considerable advances have now been made toward solvi
Generation of Systemic Lupus Erythematosus Patient-Derived Induced Pluripotent Stem Cells from Blood
Autor:
Donge Tang, Zhipeng Zeng, Shao-Dong Luan, Weilong Li, Wanxia Cai, Dongzhou Liu, Xiaoping Hong, Lianghong Yin, Yong Dai, Fengping Zheng
Publikováno v:
Stem Cells and Development. 30:227-233
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the production of multiple autoimmune antibodies and potentially involves any organ or tissue with a broad range of clinical manifestations. Conventional
Autor:
Kyoung-Mi Lee, Jin Woo Lee, Dawoon Baek, Kwang Hwan Park, Sujin Jung, Jihyun Kim, Soyeong Joung
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
The ubiquitin protease pathway plays important role in human bone marrow-derived mesenchymal stem cell (hBMSC) differentiation, including osteogenesis. However, the function of deubiquitinating enzymes in osteogenic differentiation of hBMSCs remains
Publikováno v:
Journal of Cellular and Molecular Medicine
In this study, we aimed to explore the molecular mechanisms underlying the development of osteoporosis in post‐menopausal females. Real‐time PCR was conducted to measure the expression of potential lncRNAs involved in the osteoporosis of post‐m
Autor:
Atsushi Mukai, Hiroki Hatanaka, Eiko Ito, Junji Hamuro, Shigeru Kinoshita, Morio Ueno, Chie Sotozono
Publikováno v:
Biochemical and Biophysical Research Communications. 544:31-37
To clarify the influence of tumor necrosis factor (TNF)-α on fibrotic phenotypes induced by transforming growth factor (TGF)-β in retinal pigment epithelial cells (RPECs) by epigenetic regulation. Human primary retinal pigment epithelial cells (RPE
Publikováno v:
Leukemia
Leukemia, 35(12):36163618
Leukemia, 35(12):36163618
Publikováno v:
Cell deathdisease. 13(8)
Inflammatory cytokines-induced activation of the nuclear factor κB (NF-κB) pathway plays a critical role in the pathogenesis of osteoarthritis (OA). Circular RNA (circRNA) has been identified as important epigenetic factor in numerous diseases. How
Autor:
Margot Zöller, Jamshid Hadjati, Zahra Madjd, Ehsan Ranaei Pirmardan, Roya Ghods, Marzieh Naseri, Jafar Kiani, Leila Eini, Mahmood Bozorgmehr
Publikováno v:
Journal of Cellular and Molecular Medicine
Cancer stem cells (CSCs) are responsible for therapeutic resistance and recurrence in colorectal cancer. Despite advances in immunotherapy, the inability to specifically eradicate CSCs has led to treatment failure. Hence, identification of appropriat