Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Haydn T. Kissick"'
Autor:
Haydn T. Kissick, Maria Cardenas, Jennifer W Carlisle, Adeboye O. Osunkoya, Caroline S. Jansen, Viraj A. Master, Patrick Mullane, Mehmet Asim Bilen, Rachel Greenwald, Ewelina Sobierajska, Nataliya Prokhnevska
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTumor infiltrating T-cells have a prognostic benefit in many tumor types,1–8 and we recently sought to determine whether the level of T-cell infiltration into renal tumors predicts clinical outcomes. In our recent publication,9 we showed
Autor:
Susan N. Thomas, David M. Francis, Margaret P. Manspeaker, Meghan J. O'Melia, Haydn T. Kissick, Nathan A. Rohner
Publikováno v:
Science Advances. 6
Revealing the mechanisms that underlie the expansion of antitumor CD8+ T cells that are associated with improved clinical outcomes is critical to improving immunotherapeutic management of melanoma. How the lymphatic system, which orchestrates the com
Autor:
Meghan J. O'Melia, Edmund K. Waller, Brian Pollack, Alex Schudel, David M. Francis, Margaret P. Manspeaker, Haydn T. Kissick, Susan N. Thomas, Lauren F. Sestito
Publikováno v:
Science translational medicine
Systemic administration of immune checkpoint blockade (ICB) monoclonal antibodies (mAbs) can unleash antitumor functions of T cells but is associated with variable response rates and off-target toxicities. We hypothesized that antitumor efficacy of I
Publikováno v:
Endocr Relat Cancer
Autor:
Haydn T. Kissick, Martin G. Sanda
Publikováno v:
Current Opinion in Immunology. 35:15-22
In the past few years, a number of different immunotherapeutic strategies have shown impressive results in cancer patients. These successful approaches include blockade of immunosuppressive molecules like PD-1 and CTLA-4, adoptive transfer of patient
Publikováno v:
Cancer Immunology Research. 7:A196-A196
CD8+ T-cells are responsible for detection and killing of hosT-cells expressing non-self proteins. Upon antigen persistence, as in cancer or chronic viral infection, antigen-specific CD8+ T-cells lose their effector function, a phenomenon known as T-
Autor:
Haydn T. Kissick
Publikováno v:
Cold Spring Harb Perspect Biol
Recent work by several groups has undoubtedly shown that we can produce cancer vaccines targeting neoantigens. However, each vaccine is essentially a single-use, patient-specific product, making this approach resource-intensive. For this reason, it i
Publikováno v:
Cancer Immunology Research. 4:B142-B142
Exhaustion of CD8+ T lymphocytes is a major barrier to effective clearance of chronic viral infection and cancer by the immune system. Transcriptional changes underlie the expansion and differentiation of a naive CD8+ T cell into various effector sub
Autor:
Cassandra Lee, Shruti Krishnan, Emily Bakker, Haydn T. Kissick, Demelza J. Ireland, Manfred W. Beilharz
Publikováno v:
Cytokine. 70:52
Introduction Cancer immunotherapy aims to stimulate the host’s immune system to overcome immune evasion mechanisms and destroy cancer cells. We had previously developed a Timed Triple Immunotherapy (TTI) in the TGF- β secreting AE17 murine mesothe