Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Karel Souček"'
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Simple Summary Epithelial–mesenchymal transition (EMT) and its reverse process mesenchymal–epithelial transition (MET) are considered critical events in the cancer progression. These programs are tightly connected with the development of metastas
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Autor:
Peter Kollar, Tatiana Syrovets, Tereza Kauerová, Radek Fedr, Tomáš Goněc, Ann-Kathrin Gaiser, Karel Souček, Josef Jampilek, Susanne Hafner
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3416, p 3416 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences
Volume 21
Issue 10
Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation a
Autor:
Rastislav Jendželovský, Radek Fedr, Jaromír Mikeš, Karel Souček, Peter Fedoročko, Alois Kozubík, Lucia Mikešová, Barbora Kuchárová, Ján Remšík, Ľubomír Čulka, Jana Vargová
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 99
Objective Cancer stem-like cells (CSLCs) are considered a root of tumorigenicity and resistance. However, their identification remains challenging. The use of the side population (SP) assay as a credible marker of CSLCs remains controversial. The SP
Autor:
Šárka Šimečková, Radek Fedr, Ján Remšík, Lucia Binó, Alois Kozubík, Zuzana Pernicová, Eva Slabáková, Karel Souček
Publikováno v:
Endocrine Abstracts.
Autor:
Lucia Knopfová, Eva Slabáková, Jan Bouchal, Ján Remšík, Gvantsa Kharaishvili, Petr Beneš, Lucia Binó, Tereza Nehybová, Radek Fedr, Šárka Šimečková, Karel Souček, Milan Král, Zuzana Kahounová
Publikováno v:
Cancer Research. 78:B084-B084
Dissemination of cancer cells to distant organs has fatal consequences to most of the patients with malignant tumors. Patients with prostate and breast cancer show apparent overlap of the most common sites of cancer metastasis, suggesting that breast
Autor:
Michela Muscettola, Sara Salvadori, Nila Volpi, Emanuela Maioli, Karel Souček, Claudia Torricelli, Eva Slabáková, Giuseppe Valacchi
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-based Complementary and Alternative Medicine : eCAM
Since the ability of cancer cells to evade apoptosis often limits the efficacy of radiotherapy and chemotherapy, autophagy is emerging as an alternative target to promote cell death. Therefore, we wondered whether Rottlerin, a natural polyphenolic co
Autor:
Andrea Staršíchová, Karel Souček, Alois Kozubík, Eva Slavíčková, Eva Slabáková, Zuzana Pernicová
Publikováno v:
The Prostate. 71:1332-1343
BACKGROUND. Epithelial mesenchymal transition (EMT) underlying cancer cell invasion and metastasis has been thoroughly studied in prostate cancer. Although EMT markers have been clinically observed in benign prostate hyperplasia, molecular events und
Autor:
János Szöllősi, Viktor Horváth, Jiřina Hofmanová, Alois Kozubík, Ladislav Anděra, Alena Hyršlová Vaculová, György Vereb, Petr Sova, Olga Vondálová Blanářová, Karel Souček, Árpád Szöőr, Belma Skender, Iva Jelínková
Publikováno v:
Carcinogenesis. 32:42-51
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can selectively trigger apoptosis in various cancer cell types. However, many cancer cells are resistant to death receptor-mediated apoptosis. Combination therapy with platinum complexes
Autor:
Viktor Horváth, Ales Kroutil, Adolf Mistr, Alois Kozubík, Petr Sova, František Žák, Jiřina Hofmanová, Jaroslav Turánek, Lenka Svihálková-Sindlerová, Karel Souček
Publikováno v:
Biochemical Pharmacology. 69:373-383
[(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)], coded as LA-12, is an octahedral platinum(IV) complex containing a bulky hydrophobic ligand - adamantylamine. The use of bulky hydrophobic amines as non-leaving ligands, may increa