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pro vyhledávání: '"Ebbe Boedtkjer"'
Autor:
Ebbe Boedtkjer
Publikováno v:
Boedtkjer, E 2019, ' Na +,HCO 3 – cotransporter NBCn1 accelerates breast carcinogenesis ', Cancer and Metastasis Reviews, vol. 38, no. 1-2, pp. 165-178 . https://doi.org/10.1007/s10555-019-09784-7
Cell metabolism increases during carcinogenesis. Yet, intracellular pH in solid cancer tissue is typically maintained equal to or above that of normal tissue. This is achieved through accelerated cellular acid extrusion that compensates for the enhan
Autor:
Ebbe Boedtkjer
Publikováno v:
From Malignant Transformation to Metastasis ISBN: 9783030997991
Boedtkjer, E 2022, Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression . in C Stock & L A Pardo (eds), From Malignant Transformation to Metastasis : Ion Transport in Tumor Biology . vol. 182, Springer, Reviews of Physiology, Biochemistry and Pharmacology, pp. 39-84 . https://doi.org/10.1007/112_2021_63
Boedtkjer, E 2022, Ion channels, transporters, and sensors interact with the acidic tumor microenvironment to modify cancer progression . in C Stock & L A Pardo (eds), From Malignant Transformation to Metastasis : Ion Transport in Tumor Biology . vol. 182, Springer, Reviews of Physiology, Biochemistry and Pharmacology, pp. 39-84 . https://doi.org/10.1007/112_2021_63
Solid tumors, including breast carcinomas, are heterogeneous but typically characterized by elevated cellular turnover and metabolism, diffusion limitations based on the complex tumor architecture, and abnormal intra- and extracellular ion compositio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04bf008c2a19eaf2580b4d2c69c872
https://doi.org/10.1007/112_2021_63
https://doi.org/10.1007/112_2021_63
Autor:
Anne Sofie Froelunde, Ebbe Boedtkjer, Sukhan Kim, Kristoffer B Hansen, Nicolai Jessen, Marit Edna Ohlenbusch
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)
Breast Cancer Research : BCR
Frølunde, A S, Ohlenbusch, M E, Berg-Hansen, K, Jessen, N, Kim, S & Boedtkjer, E 2018, ' Murine breast cancer feed arteries are thin-walled with reduced α 1A-adrenoceptor expression and attenuated sympathetic vasocontraction ', Breast Cancer Research, vol. 20, 20 . https://doi.org/10.1186/s13058-018-0952-8
Breast Cancer Research : BCR
Frølunde, A S, Ohlenbusch, M E, Berg-Hansen, K, Jessen, N, Kim, S & Boedtkjer, E 2018, ' Murine breast cancer feed arteries are thin-walled with reduced α 1A-adrenoceptor expression and attenuated sympathetic vasocontraction ', Breast Cancer Research, vol. 20, 20 . https://doi.org/10.1186/s13058-018-0952-8
Background Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possible therapeutic targets in matur
Autor:
Stine F. Pedersen, Eva Kjer Oernbo, Marie Kveiborg, Jacob Samsøe-Petersen, Ebbe Boedtkjer, Anne Poder Andersen, José M.A. Moreira
Publikováno v:
International Journal of Cancer. 142:2529-2542
High metabolic and proliferative rates in cancer cells lead to production of large amounts of H+ and CO2 , and as a result, net acid extruding transporters are essential for the function and survival of cancer cells. We assessed protein expression of
Publikováno v:
Aarhus University
MedChemComm 6(12), 2163-2169 (2015). doi:10.1039/C5MD00367A
Steinkamp, A-D, Seling, N, Lee, S, Boedtkjer, E & Bolm, C 2015, ' Synthesis of N-cyano-substituted sulfilimine and sulfoximine derivatives of S0859 and their biological evaluation as sodium bicarbonate co-transport inhibitors ', MedChemComm, vol. 6, pp. 2163-2169 .
MedChemComm 6(12), 2163-2169 (2015). doi:10.1039/C5MD00367A
Steinkamp, A-D, Seling, N, Lee, S, Boedtkjer, E & Bolm, C 2015, ' Synthesis of N-cyano-substituted sulfilimine and sulfoximine derivatives of S0859 and their biological evaluation as sodium bicarbonate co-transport inhibitors ', MedChemComm, vol. 6, pp. 2163-2169 .
MedChemComm 6(12), 2163-2169(2015). doi:10.1039/C5MD00367A
Published by RSC Publ., Cambridge
Published by RSC Publ., Cambridge
Publikováno v:
Lee, S, Mele, M, Vahl, P, Christiansen, P M, Jensen, V E D & Bødtkjer, E 2015, ' Na+,HCO3--cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane ', Pflügers Archiv-European Journal of Physiology, vol. 467, no. 2, pp. 367-377 . https://doi.org/10.1007/s00424-014-1524-0
Metabolic and biochemical changes during breast carcinogenesis enhance cellular acid production. Extrusion of the acid load from the cancer cells raises intracellular pH, while it decreases extracellular pH creating an inverted pH gradient across the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a96d3e9e9b8e903ecacc3f31f6d4cf2
https://pure.au.dk/portal/da/publications/nahco3cotransport-is-functionally-upregulated-during-human-breast-carcinogenesis-and-required-for-the-inverted-ph-gradient-across-the-plasma-membrane(a59484eb-b229-4992-8a50-3357b9f406f2).html
https://pure.au.dk/portal/da/publications/nahco3cotransport-is-functionally-upregulated-during-human-breast-carcinogenesis-and-required-for-the-inverted-ph-gradient-across-the-plasma-membrane(a59484eb-b229-4992-8a50-3357b9f406f2).html
Publikováno v:
Frontiers in Physiology
Aarhus University
Gorbatenko, A, Olesen, C W, Bødtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130 . https://doi.org/10.3389/fphys.2014.00130
Frontiers in Physiology, Vol 5 (2014)
Gorbatenko, A, Olesen, C W, Boedtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130, pp. 1-15 .
Aarhus University
Gorbatenko, A, Olesen, C W, Bødtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130 . https://doi.org/10.3389/fphys.2014.00130
Frontiers in Physiology, Vol 5 (2014)
Gorbatenko, A, Olesen, C W, Boedtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130, pp. 1-15 .
A unifying feature of solid tumors is a markedly altered pH profile compared to normal tissues. This reflects that solid tumors, despite completely different origins, often share several phenotypic properties with implications for intra- and extracel
Autor:
Stine F. Pedersen, Jesper Nylandsted, Rie Dybboe, Ebbe Boedtkjer, M. B. F. Jensen, Gitte Lauritzen, Christian Aalkjaer
Publikováno v:
Experimental cell research. 316(15)
Altered pH-regulatory ion transport is characteristic of many cancers; however, the mechanisms and consequences are poorly understood. Here, we investigate how a truncated, constitutively active ErbB2 receptor (DeltaNErbB2) common in breast cancer im
Autor:
Marco Mele, Ebbe Boedtkjer, Stine F. Pedersen, José M.A. Moreira, Vera Timmermans Wielenga, Christian Aalkjaer, Vibeke Jensen, Pernille Vahl, Soojung Lee, Peer Christiansen
Publikováno v:
Cancer Research. 73:P3-03
High metabolism and insufficient blood supply are characteristics of cancer tissue, which in combination with biochemical changes favor glycolytic metabolism and result in prominent intracellular acid production. Although extracellular pH at the core