Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jeremy N. Rich"'
Autor:
Jinkyu Jung, Amber J. Giles, Orieta Celiku, Wei Zhang, Brian J. Williams, Roger Abounader, Jeremy N. Rich, Mark R. Gilbert, Deric M. Park, Ying Zhang, Hua Song
Publikováno v:
Cancer Research. 79:5218-5232
Cancer cells rely on mitochondrial functions to regulate key survival and death signals. How cancer cells regulate mitochondrial autophagy (mitophagy) in the tumor microenvironment as well as utilize mitophagy as a survival signal is still not well u
Autor:
Thomas T. Egelhoff, Jeremy N. Rich, Qiao Zheng, James S. Hale, Maksim Sinyuk, Baltin Otvos, Praveena S. Thiagarajan, Alvaro G. Alvarado, Ofer Reizes, Kevin Stoltz, Justin D. Lathia, Masahiro Hitomi, Dustin Thomas, Awad Jarrar
Publikováno v:
Cancer Research. 75:P2-06
Background : Advanced cancers including triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, contain a self-renewing, tumorigenic cancer stem cell (CSC) population. CSCs contribute to tumor progression and therapeutic resi
Autor:
Wenchao Zhou, Xiaoguang Fang, Richard A. Prayson, Jeremy N. Rich, Jianghong Man, Jennifer S. Yu, Jocelyn Shoemake, Anthony Rizzo, Qiulian Wu, Shideng Bao
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1812-1826 (2014)
Summary: Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs) are a subset of tumor cells that resist standard therapy to contribute to disease progression. How GSCs employ
Autor:
Laura Donohue, Daniel P. Cahill, Mario L. Suvà, Jon C. Aster, Hiroaki Wakimoto, Sarah J. Shareef, Jeremy N. Rich, Christopher D. Carey, Brian B. Liau, Peter van Galen, Fadi J. Najm, William A. Flavahan, Christine Hebert, Shawn M. Gillespie, Tyler E. Miller, Scott J. Rodig, Cem Sievers, Anoop P. Patel, Andrew S. Venteicher, Bradley E. Bernstein
Publikováno v:
Cell stem cell. 20(2)
Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by stem-like cancer cells refractory to existing therapies. Understanding the molecular mechanisms that control glioblastoma stem cell (GSC) proliferation and drug resi
Autor:
Anita B Hjlemeland, Diana Basali, Ofer Reizes, Stephen D. Hursting, Nathan A. Berger, Qiao Zheng, Justin D. Lathia, Sarah L. Fracci, Amit Vasanji, Sarah M. Dunlap, Jeremy N. Rich, Lauren Banaszak
Publikováno v:
Endocrine-Related Cancer. 20:797-808
Despite new therapies, breast cancer continues to be the second leading cause of cancer mortality in women, a consequence of recurrence and metastasis. In recent years, a population of cancer cells has been identified, called cancer stem cells (CSCs)
Publikováno v:
Biochemical and Biophysical Research Communications. 406:643-648
Glioblastomas (GBMs) are the most lethal and common types of primary brain tumors. The hallmark of GBMs is their highly infiltrative nature. The cellular and molecular mechanisms underlying the aggressive cancer invasion in GBMs are poorly understood
Publikováno v:
Biochemical Pharmacology. 80:654-665
Glioblastoma is the most common and lethal type of primary brain tumor. Despite recent therapeutic advances in other cancers, the treatment of glioblastomas remains ineffective and essentially palliative. The treatment failure is a result of a number
Autor:
Wen-Chi Foo, Jeremy N. Rich, Anita B. Hjelmeland, Katherine M. LaFiura, Christine E. Eyler, Roger E. McLendon
Publikováno v:
Stem Cells. 26:3027-3036
Malignant brain tumors are among the most lethal cancers, and conventional therapies are largely limited to palliation. Novel therapies targeted against specific molecular pathways may offer superior efficacy and less toxicity than conventional thera
Autor:
Christine E. Eyler, Jeremy N. Rich
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 73:411-420
Tumors are aberrant organ systems containing a complex interplay between the neoplastic compartment and recruited vascular, inflammatory, and stromal elements. Furthermore, most cancers display a hierarchy of differentiation states within the tumor c
Autor:
Jeremy N. Rich
BACKGROUND: Gliomas display cellular hierarchies with tumor initiating cells (TICs) at the apex that are functionally defined by the ability to self renew and propagate tumors similar to the parental tumors from which they are derived. TICs remain co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df1b43d2ad7c2cf2d7dd332fb3b13ba
https://europepmc.org/articles/PMC4144524/
https://europepmc.org/articles/PMC4144524/