Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Silvana Morello"'
Autor:
Elena De Marchi, Anna Pegoraro, Roberta Turiello, Francesco Di Virgilio, Silvana Morello, Elena Adinolfi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
ATP and adenosine are key constituents of the tumor niche where they exert opposite and complementary roles. ATP can be released in response to cell damage or actively released by tumor cells and subsequently degraded into adenosine, which accumulate
Externí odkaz:
https://doaj.org/article/e176bc02db0345e7a0589c15adea8acb
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/4060fe43ea9846b4951c78bf6c6570db
Autor:
Kilian Wistuba-Hamprecht, Antje Sucker, Mitchell P. Levesque, Gabriele Madonna, Jason J. Luke, Elva Morretta, Aldo Pinto, Roberta Turiello, Diana Giannarelli, Benjamin Weide, Paolo A. Ascierto, Laurence Imhof, Lucia Festino, Rosa Azzaro, Teresa Amaral, Piotr Rutkowski, Reinhard Dummer, Mariaelena Capone, Céleste Lebbé, Domenico Mallardo, Dirk Schadendorf, Maria Chiara Monti, Silvana Morello, Marc Chevrier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundInhibitors of immune checkpoint programmed cell death protein 1 (PD-1) receptor on T cells have shown remarkable clinical outcomes in metastatic melanoma. However, most patients are resistant to therapy. Production of extracellular adenosin
Autor:
Aldo Pinto, Silvana Morello, Diana Giannarelli, Paolo A. Ascierto, Antonio Pinto, Roberta Turiello, Serena Zanotta, Marilena Tuffanelli, Gabriele Madonna, Ernesta Cavalcanti, Mariaelena Capone, Antonio M. Grimaldi, Assunta Esposito, Rosa Azzaro, Domenico Galati, Federica Fratangelo, Claudia Sorrentino, Luigi Scarpato
Publikováno v:
Journal of Translational Medicine
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-10 (2020)
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-10 (2020)
Background PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify reliable biomarkers for outcome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc81a8e92424ae92b92fb5387b44324
http://hdl.handle.net/11386/4743544
http://hdl.handle.net/11386/4743544
Autor:
Gabriele Madonna, Aldo Pinto, Mariaelena Capone, Roberta Turiello, Silvana Morello, Paolo A. Ascierto
CD73 is an ectonucleotidase able to catabolize 5'-adenosine monophosphate (AMP) into adenosine at the extracellular level. Extracellular adenosine plays a critical role in regulating many processes under physiological and pathological conditions. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8826fb2d081a5072a3d9a8fb96f3f3c
https://doi.org/10.1016/bs.mie.2019.05.044
https://doi.org/10.1016/bs.mie.2019.05.044
Autor:
Silvana Morello, Maria Strianese, Claudio Pellecchia, Maria Caterina Turco, Anna Basile, Antonio Mazzone
Publikováno v:
Journal of Cellular Physiology. 228:2202-2209
Vanadium compounds can exert anticancer effects, partly due to inhibition of tyrosine phosphatases. Here, we report the effect of N,N'-ethylenebis (pyridoxylideneiminato) vanadium (IV) complex (Pyr2 enV(IV)), that induced 93% and 57% of cell mortalit
Adenosine, deriving from ATP released by dying cancer cells and then degradated in the tumor environment by CD39/CD73 enzyme axis, is linked to the generation of an immunosuppressed niche favoring the onset of neoplasia. The effects of adenosine are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ecc0f1e26c4e2e7f5316931bf84f9b
http://hdl.handle.net/11386/4654929
http://hdl.handle.net/11386/4654929
Publikováno v:
Cancer immunology, immunotherapy : CII. 60(9)
Lung carcinoma is one of the leading causes of death worldwide. It is a non-immunogenic cancer, resistant to immune surveillance. Toll-like receptors (TLRs) connect the innate to the adaptive immune system. Given that cancerous cells evade the immune
Publikováno v:
OncoImmunology. 2:e22448
High amounts of adenosine are released in the tumor mass. Depending on the levels of adenosine, as well as on the receptor subtypes that are expressed by immune cells, adenosine can affect tumor growth in different fashions. Specifically targeting CD