Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Quansheng Zhou"'
Autor:
Zhe Zhao, Shufen Xiang, Bin Zhang, Chunping Lv, Zihe Huo, Zhifei Cao, Mei Meng, Gaochuan Zhang, Quansheng Zhou, Liang Dong, Lan Yang, Bo Yang, Pan Zhang, Shucheng Shi, Xingdong Xu
Publikováno v:
Cell Death Differ
Cancer cells are defective in DNA repair, so they experience increased DNA strand breaks, genome instability, gene mutagenesis, and tumorigenicity; however, multiple classic DNA repair genes and pathways are strongly activated in malignant tumor cell
Autor:
Mengli Zhang, Di Yu, Bin Zhang, Zhifei Cao, Pan Zhang, Zhe Zhao, Shijie Tan, Chunping Lv, Quansheng Zhou
Publikováno v:
Toxicology and Applied Pharmacology. 365:1-8
Lung cancer is a leading lethal disease with a 5-year survival rate of only 16%. Inadequate potent anti-cancer drugs appear to be a bottleneck in the treatment of lung cancer; hence, how to develop effective anti-lung cancer therapeutics is an urgent
Publikováno v:
Biochimica et biophysica acta. Reviews on cancer. 1876(1)
Increasing evidence shows that numerous cancer-testis antigens (CTAs) are uniquely overexpressed in various types of cancer and most CTAs are oncogenic. Overexpression of oncogenic CTAs promotes carcinogenesis, cancer metastasis, and drug resistance.
Autor:
Jindan Qi, Shufen Xiang, Tong Zhang, Quansheng Zhou, Mengli Zhang, Yijun Wei, Mei Meng, Jun Yao, Xiaohua Wang, Zhe Zhao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Salvador homolog-1 (SAV1) is a tumor suppressor required for activation of the tumor-suppressive Hippo pathway and inhibition of tumorigenesis. SAV1 is defective in several cancer types. SAV1 deficiency in cells promotes tumorigenesis and cancer meta
Publikováno v:
Toxicology and applied pharmacology. 388
Gastric cancer ranks as the third leading cause of cancer-related death worldwide. The uncontrolled tumor growth and robust metastasis are key factors to cause the cancer patient death. Mechanistically, aberrant activation of Notch and NF-κB signali
Publikováno v:
Biochemical Pharmacology. 104:8-18
Gastric cancer is ranked as the third leading cause of cancer-related death in the world. Although extensive efforts have been made in recent decades to treat gastric cancer with various anticancer drugs, effective anti-gastric cancer therapeutics to
Autor:
Yanyan Pan, Bin Zhang, Wenming Liu, Mei Meng, Longsheng Du, Zhifei Cao, Ping Yang, Quansheng Zhou, Zhenlun Gu
Publikováno v:
Toxicology and Applied Pharmacology. 287:98-110
Accumulated data has shown that various vasculogenic tumor cells, including gastric cancer cells, are able to directly form tumor blood vessels via vasculogenic mimicry, supplying oxygen and nutrients to tumors, and facilitating progression and metas
Decoding the Knots of Initiation of Oncogenic Epithelial-Mesenchymal Transition in Tumor Progression
Publikováno v:
Current Cancer Drug Targets. 13:996-1011
Oncogenic epithelial-mesenchymal transition (oncEMT) plays important roles in the genesis of cancer stem cells (CSCs), malignant tumor initiation and progression, cancer metastasis, and drug resistance. Although the role of oncEMT in tumorigenesis ha
Publikováno v:
Cancer Microenvironment. 5:211-223
Tumor microenvironment (TME) is important in tumor development and may be a target for anti-cancer therapy. The genesis of TME is a dynamic process that is regulated by intrinsic and extrinsic factors and coordinated by multiple genes, cells, and sig
Publikováno v:
Current cancer drug targets. 17(1)
MicroRNAs (miRNAs) control the expression of approximately 60% of protein-coding genes and regulate cell metabolism, proliferation, differentiation, and apoptosis. Notably, aberrant expression of miRNAs contributes to several diseases including cance