Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Marlana Orloff"'
Autor:
Bao Quoc Lam, Andrew E. Aplin, Grazia Ambrosini, Takahito Sugase, Vivian Chua, Connie Liao, Marlana Orloff, Mizue Terai, Takami Sato, Gary K. Schwartz, Timothy J. Purwin, Jessica L.F. Teh, Richard D. Carvajal
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 11, Iss 2, Pp n/a-n/a (2019)
EMBO Molecular Medicine, Vol 11, Iss 2, Pp n/a-n/a (2019)
Alterations in transcriptional programs promote tumor development and progression and are targetable by bromodomain and extraterminal (BET) protein inhibitors. However, in a multi‐site clinical trial testing the novel BET inhibitor, PLX51107, in so
Autor:
Jane Harper, Paul C. Nathan, Shaad Essa Abdullah, Takami Sato, Christopher J. Holland, Chris Cohen, Richard D. Carvajal, Joseph J. Sacco, Marlana Orloff
Publikováno v:
Cancer Research. 80:3295-3295
Background Tebentafusp, a TCR-anti-CD3 bispecific fusion protein designed to target a peptide from melanocyte lineage antigen gp100, has shown monotherapy activity in advanced cutaneous and uveal melanoma (UM) [1]. gp100 is expressed in normal melano
Autor:
Matias E. Valsecchi, Inna Chervoneva, Marlana Orloff, Liam Hulse, Jerry A. Shields, Shingo Sato, Michael J. Mastrangelo, Erin Sharpe-Mills, Ayako Shimada, Carol L. Shields, Takami Sato, Jill Belinsky, Jessica Norcini, Haley Klose
Publikováno v:
Journal of Clinical Oncology. 38:e22059-e22059
e22059 Background: Uveal melanoma is the most common primary intraocular cancer in adults. Despite successful treatment of primary tumors, up to 50% of patients later die of distant metastases. Currently, no effective adjuvant treatment is available.
Autor:
Mizue Terai, Meggie Danielson, Emma Link, David J. Eschelman, Rober D. Adamo, Takami Sato, Carin F. Gonsalves, Marlana Orloff
Publikováno v:
Cancer Research. 79:4052-4052
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Despite successful treatments for primary UM, up to 50% of patients subsequently develop systemic metastasis, often in the liver. Treatment options are limited after dev
Publikováno v:
Cancer Research. 78:3805-3805
Uveal (eye) melanoma (UM) is the most common primary eye malignancy in adults. Despite effective treatments for primary UM, up to 50% of patients subsequently develop systemic metastasis, predominantly in the liver. Once hepatic metastasis develops,
Autor:
Asad Javed, Takami Sato, Michael J. Mastrangelo, Curtis Johnston, David Arguello, Marlana Orloff, Zoran Gatalica
Publikováno v:
Journal of Clinical Oncology. 34:9541-9541
9541Background: Programmed death-ligand 1 (PD-L1) is expressed by various cells such as dendritic cells and tumor cells. In cancer, tumors evade the immune system by the interaction of PD-L1 with P...
Autor:
Takami Sato, Massimo Cristofanilli, Mizue Terai, Carin F. Gonsalves, Marlana Orloff, Zhaomei Mu, Ken Kageyama, Michael J. Mastrangelo, Ryan M. Weight, David J. Eschelman
Publikováno v:
Cancer Research. 75:384-384
Background: Circulating tumor cells (CTCs) represent a surrogate biomarker for hematogenous metastases. The detection of CTCs has gained increasing interest for prediction of clinical outcome. However, it remains to be determined whether uveal melano
Autor:
Xuechan Li, Antonio Giordano, Mario Giuliano, Rui Duan, Massimo Cristofanilli, Marlana Orloff, Terry Hyslop, Hallgeir Rui, James M. Reuben
Publikováno v:
Cancer Research. 75:5295-5295
The baseline and longitudinal monitoring of circulating tumor cells (CTCs) demonstrated strong prognostic and predictive value in patients with metastatic breast cancer (MBC) irrespective of tumor subtype but particularly in ER+ disease. Utilizing a